Overview
- Written by leading experts in the field
- Addresses key aspects of the process of thymopoiesis
- Offers perspectives for understanding immunodeficiency and autoimmune diseases
- Includes supplementary material: sn.pub/extras
Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 373)
Buy print copy
About this book
The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.
Similar content being viewed by others
Keywords
Table of contents (6 chapters)
Editors and Affiliations
Bibliographic Information
Book Title: Thymic Development and Selection of T Lymphocytes
Editors: Thomas Boehm, Yousuke Takahama
Series Title: Current Topics in Microbiology and Immunology
DOI: https://doi.org/10.1007/978-3-642-40252-4
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2014
Hardcover ISBN: 978-3-642-40251-7Published: 19 November 2013
Softcover ISBN: 978-3-662-51196-1Published: 23 August 2016
eBook ISBN: 978-3-642-40252-4Published: 06 November 2013
Series ISSN: 0070-217X
Series E-ISSN: 2196-9965
Edition Number: 1
Number of Pages: VII, 132
Number of Illustrations: 2 b/w illustrations, 9 illustrations in colour
Topics: Immunology, Human Physiology, Cytogenetics