Overview
- Very few books about Sigma receptors, yet the field regarding Sigma receptors has exploded
- A comprehensive treatise on this unique protein
- Of significant relevance to very severe diseases (blindness, ALS, AD, PK, pain, schizophrenia, HD)
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 964)
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About this book
Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets. In this text, new information about the structure of sigma 1 receptor, its binding sites are provided as well as its expression in many cell types. It’s putative role in degenerative neuronal diseases including amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, pain, drug addiction and locomotor activity. Their roles in possible treatments for blinding retinal diseases emphasize the tremendous far-reaching potential for ligands for these receptors. Exciting breakthroughs in this dynamic field in the last decade are reported herein, which will guide future investigators in determining the full potential of this unique, yet abundantly expressed protein.
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Table of contents (20 chapters)
Editors and Affiliations
Bibliographic Information
Book Title: Sigma Receptors: Their Role in Disease and as Therapeutic Targets
Editors: Sylvia B. Smith, Tsung-Ping Su
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-3-319-50174-1
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing AG (outside the USA) 2017
Hardcover ISBN: 978-3-319-50172-7Published: 27 March 2017
Softcover ISBN: 978-3-319-84335-3Published: 13 June 2018
eBook ISBN: 978-3-319-50174-1Published: 16 March 2017
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XIII, 312
Number of Illustrations: 14 b/w illustrations, 45 illustrations in colour
Topics: Biomedicine general, Protein Science, Receptors