Overview
- Summarizes the tremendous
- progress made within the last decade in understanding the roles of lncRNA in
- Bridges the divide between inferring lncRNA mechanisms and targeting lncRNAs by means of rational therapeutics
- Stresses the vital role of lncRNA disease mechanisms for a necessary and profound reassessment of Genome-Wide Association studies in the new era of personalized medicine
- Includes supplementary material: sn.pub/extras
Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 394)
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About this book
This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike.
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Table of contents (10 chapters)
Editors and Affiliations
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Bibliographic Information
Book Title: Long Non-coding RNAs in Human Disease
Editors: Kevin V. Morris
Series Title: Current Topics in Microbiology and Immunology
DOI: https://doi.org/10.1007/978-3-319-23907-1
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2016
Hardcover ISBN: 978-3-319-23906-4Published: 22 April 2016
Softcover ISBN: 978-3-319-79551-5Published: 22 April 2018
eBook ISBN: 978-3-319-23907-1Published: 13 April 2016
Series ISSN: 0070-217X
Series E-ISSN: 2196-9965
Edition Number: 1
Number of Pages: VIII, 262
Topics: Cancer Research, Immunology, Human Genetics