Overview
- Presents detailed, current knowledge on pathogenic prion proteins and prion diseases
- Covers emerging topics such as inherited human prion disease, stem-cell models in prion research
- Brings together the world's leading authorities on prions and prion diseases
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About this book
Transmissible spongiform encephalopathies (TSE), known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. Modern studies, including the protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In the second edition of Prions and Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date discussion of these unique infectious pathogens and their associated diseases. The book provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the full range of animal and human prion diseases. As a result, the book contains by far the most authoritative views about the past, present, and future of prions and prion diseases. The new second edition covers such important emerging topics such as inherited human prion disease, stem-cell models in prion research, human prion disease surveillance, and gene therapy strategies.
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Keywords
Table of contents (37 chapters)
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Front Matter
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Environment and Transmission of Prions
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Front Matter
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Modelling of Prions
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Front Matter
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Editors and Affiliations
About the editors
Wen-Quan Zou, MD, PhD is Professor of Pathology at Case Western University School of Medicine, and he is Associate Director of the National Prion Disease Pathology Surveillance Center.
Pierluigi Gambetti, MD, is Professor of Pathology and Neurology at Case Western University School of Medicine.
Bibliographic Information
Book Title: Prions and Diseases
Editors: Wen-Quan Zou, Pierluigi Gambetti
DOI: https://doi.org/10.1007/978-3-031-20565-1
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023
Hardcover ISBN: 978-3-031-20564-4Published: 02 January 2023
Softcover ISBN: 978-3-031-20567-5Published: 03 January 2024
eBook ISBN: 978-3-031-20565-1Published: 01 January 2023
Edition Number: 2
Number of Pages: XII, 793
Number of Illustrations: 19 b/w illustrations, 62 illustrations in colour
Topics: Neurosciences, Human Physiology, Neurology, Protein Science, Animal Physiology, Biochemistry, general