Overview
- Enriches understanding of brain histaminergic system functions
- Reviews exhaustively the key recent findings on preclinical and clinical research
- Covers the clinical areas that are in major need of new therapeutic approaches
Part of the book series: Current Topics in Behavioral Neurosciences (CTBN, volume 59)
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About this book
Research in the field of histamine receptors over the past 100 years went hand-in-hand with the development of modern pharmacology. Advances in histamine research led by outstanding scientists was so incisive that the clinical approach to treat allergies and gastrointestinal ailments was revolutionized. The pharmacological treatment of peptic ulcer and gastroesophageal reflux was indeed a revolution, as it ended the surgical intervention.
Interest in histamine pharmacology was resurrected by the discovery of another histamine receptor, number 4, using genomics-based reverse pharmacological approaches for screening orphan GPCRs. This receptor is preferentially expressed by immune cells and its discovery raised hopes for its translational exploitation as a new therapeutic target for unmet medical needs ranging from asthma to cancer. However, several drawbacks emerged and dramatically slowed down research in the field.
A better understanding of receptor intra-andinterspecies heterogeneity will certainly improve and accelerate the translation of experimental data into clinical practice. Also, the plethora of data on brain histamine is hinting at a fundamental role of this system as a hub that receives internal and peripheral stimuli to allocate the necessary excitation to specific brain circuits that preside the appropriate behavioral responses.
The aim of this book is to cover the most important aspects of histamine receptor function and pharmacology in the central nervous system and to provide a comprehensive overview of the preclinical and clinical advances made in recent decades and the exciting prospects for the future. It highlights the clinical areas where there is a great need for new therapeutic approaches and where novel histaminergic agents may be useful for personalized medicine.
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Table of contents (20 chapters)
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Front Matter
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Pharmacology and Medicinal Chemistry
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Front Matter
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Clinical Pharmacology
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Front Matter
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The Immune and Inflammatory Response in the Brain
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Front Matter
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Neuropharmacology: Histamine and Behaviour
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Front Matter
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Editors and Affiliations
Bibliographic Information
Book Title: The Functional Roles of Histamine Receptors
Editors: Kazuhiko Yanai, Maria Beatrice Passani
Series Title: Current Topics in Behavioral Neurosciences
DOI: https://doi.org/10.1007/978-3-031-16997-7
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022
Hardcover ISBN: 978-3-031-16996-0Published: 30 September 2022
Softcover ISBN: 978-3-031-16999-1Published: 02 October 2023
eBook ISBN: 978-3-031-16997-7Published: 28 September 2022
Series ISSN: 1866-3370
Series E-ISSN: 1866-3389
Edition Number: 1
Number of Pages: IX, 468
Number of Illustrations: 70 b/w illustrations, 30 illustrations in colour
Topics: Neurosciences, Medicinal Chemistry