Overview
- Examines the genetics of familial pancreatic cancer
- Discusses molecularly targeted therapies in pancreatic cancer
- Explores new technologies in molecular characterization of pancreatic cancer
- Includes supplementary material: sn.pub/extras
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About this book
Pancreatic cancer is a formidable disease, and advances in early detection and improved therapeutics have been slow to come forth. With new advances in molecular genetics in the field of pancreatic tumorigenesis, it is an opportune time to use these recent discoveries to enhance our understanding of pancreatic cancer biology and to improve outcomes in patients.
In this volume, leading experts in the field shed light on these findings describing the mutational landscape of pancreatic cancer, including new inroads into our understanding of familial pancreatic cancer, epidemiology, the biology of K-ras signaling, and the emerging contribution of epigenetic alterations to disease initiation and progression. The distinctive pancreatic cancer-stroma ecosystem as determined by the dynamic interplay of inflammation, hallmark mutations, EMT, and cancer stem cells is described, and implications of these interactions in the context of development of novel, personalized therapeutic options are explored.
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Table of contents (10 chapters)
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Front Matter
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Back Matter
Editors and Affiliations
Bibliographic Information
Book Title: Molecular Genetics of Pancreatic Cancer
Editors: Diane M. Simeone, Anirban Maitra
DOI: https://doi.org/10.1007/978-1-4614-6549-2
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media, LLC 2013
Hardcover ISBN: 978-1-4614-6548-5Published: 05 April 2013
Softcover ISBN: 978-1-4899-9435-6Published: 20 May 2015
eBook ISBN: 978-1-4614-6549-2Published: 05 April 2013
Edition Number: 1
Number of Pages: V, 235
Topics: Cancer Research, Cell Biology, Human Genetics