Overview
- Includes cutting-edge methods and protocols
- Provides step-by-step detail essential for reproducible results
- Contains key notes and implementation advice from the experts
Part of the book series: Methods in Molecular Biology (MIMB, volume 2342)
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About this book
This second edition further develops the principles of applying kinetic principles to drug metabolizing enzymes and transporters. Chapters are divided into six sections detailing fundamental principles of enzyme kinetics, enzyme and transporter structures, highlighting specific oxidative and conjugative drug metabolizing enzymes and drug transporters, modeling approaches for drug metabolizing enzymes and transporters, understanding of variability both experimental and interindividual (pharmacogenomic), and expanded case studies that provide real life examples of applying these principles. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, in some cases step-by-step instructions with readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls with extensive cross referencing to assist in learning.
Authoritativeand fully updated, Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications, Second Edition serves as a practical teaching tool for novice and advanced scientists interested in the fundamental concepts.
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Keywords
Table of contents (31 protocols)
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Underlying Principles of Enzyme Kinetics
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Crystal Structure, Biochemistry, and Impact on Enzyme Kinetics
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Kinetics of Drug Metabolizing Enzymes and Transporters
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Modeling Considerations
Editors and Affiliations
Bibliographic Information
Book Title: Enzyme Kinetics in Drug Metabolism
Book Subtitle: Fundamentals and Applications
Editors: Swati Nagar, Upendra A. Argikar, Donald Tweedie
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-0716-1554-6
Publisher: Humana New York, NY
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2021
Hardcover ISBN: 978-1-0716-1553-9Published: 17 July 2021
Softcover ISBN: 978-1-0716-1556-0Published: 18 July 2022
eBook ISBN: 978-1-0716-1554-6Published: 16 July 2021
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 2
Number of Pages: XXVII, 881
Number of Illustrations: 29 b/w illustrations, 129 illustrations in colour