Summary
Tuberous sclerosis complex (TSC) is an uncommon multiorgan disorder that may present many and different manifestations on imaging. Radiology plays an important role in diagnosis and management, and can substantially improve the clinical outcome of TSC. Therefore, a comprehensive understanding of this disease is essential for the radiologist. The manifestations of TSC on computer tomography (CT) and magnetic resonance (MR) images were analyzed. Eleven patients with a clinical diagnosis of TSC were retrospectively reviewed. Central nervous system lesions included subependymal nodules (SENs) (11/11), subependymal giant cell astrocytomas (SEGAs) (2/11), cortical and subcortical tuber lesions (5/11), and white matter lesions (4/11). Of the 6 patients with abdominal scans, there were 6 cases of renal angiomyolipomas (AMLs), and one case of hepatic AMLs. Of the 4 patients undergoing chest CT, lung lymhangioleiomyomatosis (LAM) (2/4), and multiple small sclerotic bone lesions (2/4) were observed. Different modalities show different sensitivity to the lesion. Analysis of images should be integrated with patients’ history in order to diagnose TSC.
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References
Baskin HJ. The pathogenesis and imaging of the tuberous sclerosis complex. Pediatr Radiol, 2008, 38(9):936–952
Celenk P, Alkan A, Canger EM, et al. Fibrolipomatous hamartoma in a patient with tuberous sclerosis: report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2005,99(2):202–206
Radhakrishnan R, Verma S. Clinically relevant imaging in tuberous sclerosis. J Clin Imaging Sci, 2011,1:39
Maria BL, Deidrick KM, Roach ES, et al. Tuberous sclerosis complex: pathogenesis, diagnosis, strategies, therapies, and future research directions. J Child Neurol, 2004,19(9):632–642
Kalantari BN, Salamon N. Neuroimaging of tuberous sclerosis: spectrum of pathologic findings and frontiers in imaging. AJR Am J Roentgenol, 2008,190(5):W304–309
Baron Y, Barkovich J. MR imaging of tuberous sclerosis in neonates and young infants. AJNR Am J Neuroradiol 1999,20(5):907–916
Gallagher A, Grant EP, Madan N, et al. MRI findings reveal three different types of tubers in patients with tuberous sclerosis complex. J Neurol, 2010, 257(8):1373–1381
Ridler K, Suckling J, Higgins N, et al. Standardized whole brain mapping of tubers and subependymal nodules in tuberous sclerosis complex. J Child Neurol, 2004,19(9):658–665
Van Tassel P, Cure JK, Holden KR. Cystlike white matter lesions in tuberous sclerosis. AJNR Am J Neuroradiol, 1997,18(7):1367–1373
Dixon BP, Hulbert JC, Bissler JJ. Tuberous sclerosis complex renal disease. Nephron Exp Nephrol, 2011,118(1):e15–20
Shin NY, Kim MJ, Chung JJ, et al. The differential imaging features of fat-containing tumors in the peritoneal cavity and retroperitoneum: the radiologic-pathologic correlation. Korean J Radiol, 2010, 11(3):333–345
Chao CH, Lin CY, Chan SC, et al. Concurrent hepatic and ruptured renal angiomyolipoma in tuberous sclerosis complex. Chang Gung Med J, 2004,27(9):696–700
Seaman DM, Meyer CA, Gilman MD, et al. Diffuse cystic lung disease at high-resolution CT. AJR Am J Roentgenol, 2011,196(6):1305–1311
Castro M, Shepherd CW, Gomez MR, et al. Pulmonary tuberous sclerosis. Chest, 1995,107(1):189–195
O'Callaghan FJ, Clarke AC, Joffe H, et al. Tuberous sclerosis complex and Wolff-Parkinson-White syndrome. Arch Dis Child, 1998,78(2):159–162
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Hu, S., Hu, Dy., Zhu, Wz. et al. Tuberous sclerosis complex: Imaging characteristics in 11 cases and review of the literature. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 36, 601–606 (2016). https://doi.org/10.1007/s11596-016-1632-5
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DOI: https://doi.org/10.1007/s11596-016-1632-5