Abstract
In this paper, we propose a delayed fractional-order gene regulatory network model. Firstly, the sum of delays is chosen as the bifurcation parameter, and the conditions of the existence for Hopf bifurcations are achieved through analyzing its characteristic equation. Secondly, it is shown that the fractional order can be effectively manipulated to control the dynamics of such network, and the stability domain can be changed with different fractional orders. The fractional-order genetic network can generate a Hopf bifurcation (oscillation appears) as the sum of delays passes through some critical values. Therefore, we can achieve some desirable dynamical behaviors by choosing the appropriate fractional order. Finally, numerical simulations are carried out to illustrate the validity of our theoretical analysis.
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1 Introduction
As we know, fractional calculus is a common generalization of an arbitrary, which was originally proposed in the late seventeenth century. In recent years, the fractional-order derivatives and integrals have been widely used in numerous branches of science and engineering. It has been found that dynamical equations using fractional derivatives are useful and more accurate in the mathematical modeling of real world phenomena arising from several fields, such as colored noises [1], diffusion and wave propagation [2], electromagnetic wave [3], control [4], biological systems [5], and so on. In fact, many real-world physical systems can be more accurately described by fractional-order differential equations than integer-order ones.
Numbers of genes and gene products consist of a genetic regulatory network with regulatory interactions. Its dynamical systems are extremely complicated, which can represent the interaction functions in gene expression [6, 7]. The Genetic regulatory network describes interactions between DNAs, RNAs, proteins and small molecules in an organism [8]. So it is necessary and important to investigate the dynamics of gene regulatory networks to get insight to its mechanism.
Time delays are inevitably in many real dynamical systems, such as biological systems, neural networks and so on. In [9], a mathematical model was proposed to describe the interaction of inducible defenses and herbivore outbreak. It was proved that time delays play a pivotal role in the persistence of herbivore populations. In [10], the effect of periodic sub-threshold pacemaker activity and time-delayed coupling on stochastic resonance over scale-free neuronal networks was considered. It was shown that finite delays in coupling can significantly affect the stochastic resonance on scale-free neuronal networks. Time delays can lead to complex dynamical behaviors for systems, and an appropriate delay can also improve the stability of systems. Therefore, it is necessary to investigate the effect that time delays cause on dynamical behaviors of complex systems theoretically and practically.
Hopf bifurcation analysis is an efficient tool to acquire more information around the equilibrium point of complex dynamical networks [11,12,13,14,15]. It is well known that the Hopf bifurcation in delayed inter-order systems has been extensively studied, and numerous valuable results have been obtained. Due to the development of fractional calculus, the study of Hopf bifurcations of fractional-order models has attracted an increasing interest in recent years [16,17,18,19]. Unfortunately, the impact of time delays on these fractional-order models are rarely taken account to.
The integer-order calculus is only determined by the local character of the function, while the fractional-order calculus can accumulate the global information of the function in the weighted form, which is also called the memory. The integer-order calculus is a special case of fractional calculus, and almost all physical systems can be described with fractional-order models. In the last decade, fractional-order models have been an active field of research both from a theoretical and applied perspective. For instance, the resistance-capacitance-inductance (RLC) interconnect model of a transmission line is a fractional-order model [20]. Heat conduction can be more adequately modeled by fractional-order models than by their integer-order counterparts [21].
Recently, quite a few studies have been conducted on the Hopf bifurcation analysis of genetic regulatory networks [22,23,24,25,26]. However, most of these results have only considered integer-order genetic regulatory networks. Magin [27] argued that the activities of the organism can be accurately described by using the fractional-order derivative. In [28], a new approach based on fractional differential equations to build the genetic regulatory networks from time series data was proposed. It was revealed that the proposed mathematical model is more suitable to model genetic regulatory mechanism. In [29], a class of fractional-order gene regulatory networks was studied. Some criteria on the Mittag–Leffler stability and generalized Mittag–Leffler stability were established by using the fractional Lyapunov method for these networks. In [30], a fractional gene regulatory algorithm by extended fractional Kalman filter was proposed to estimate the hidden states as well as the unknown static parameters of the model. The mathematical model based on the fractional-order differential equation can describe the dynamic response of the actual system more accurately, and further improve the design, characterization and control of dynamical systems.
Till now, there are few results with regard to fractional-order genetic regulatory networks. The existing work on the dynamics of fractional-order genetic regulatory networks pays little attention to the effect of time delays. The time delay is an essential factor when modeling genetic networks due to slow biochemical processes such as gene transcription, translation and transportation. Motivated by those facts, the problem of the bifurcation for delayed fractional-order genetic regulatory networks is investigated in the present paper.
The rest of this paper is organized as follows. In Sect. 2, some definitions are recalled and the delayed fractional-order genetic network model is presented. In Sect. 3, the stability and bifurcation of the delayed fractional-order genetic regulatory network is analyzed. In Sect. 4, the simulation examples are given to illustrate the results. Finally, the conclusions are drawn in Sect. 5.
2 Preliminaries and Model Description
Generally speaking, there are three definitions of fractional derivatives: the Grunwald–Letnikov fractional derivative, Riemann–Liouville fractional derivative, and Caputo fractional derivative [31]. The Caputo derivative only requires initial conditions given by means of integer-order derivative, which has well understood physical meanings and has more applications in engineering. The Caputo derivative will be used in this paper.
The Caputo fractional-order derivative is defined as follows:
where \(m-1<\alpha <m,m\in N,\) and \(\Gamma (\cdot )\) is the Gamma function. The symbol \(\alpha \) denotes the value of the fractional order that is usually chosen in the range \(0<\alpha \le 1.\)
The Laplace transform of the Caputo fractional-order derivative is represented by:
If \(f^{(k)}(0)=0, \quad k=0,1,\ldots ,m-1,\) then \(L\{{ }_0^C D_t^\alpha f(t)\}=s^{\alpha }F(s).\)
Lewis [32] proposed a single-gene regulatory network model with time delays described by the following equations:
where m(t) and p(t) are the concentrations of the mRNA and protein, respectively, \(c>0\) and \(b>0\) are the degradation rates of the mRNA and protein, respectively, and \(a>0\)is the synthesis rate of the protein. The time delay \(\tau _{1} \) elapses between the initiation of transcription and the arrival of the mature mRNA molecule in the cytoplasm, and \(\tau _{2} \) elapses between the initiation of translation and the emergence of a complete functional protein molecule. In addition, g(p(t))is the rate of the production of the mRNA, and g(x)can be expressed with a sigmoid function, \(\in \tanh (x)\)or a function of the Hill form, \(\sigma /(x^{n}+\in )\), where \(\in \) and \(\sigma \) are positive numbers and n is the Hill coefficient denoting the degree of cooperativity [33].
In this paper, we are interested in the dynamics of the following delayed fractional-order model of genetic regulatory networks:
where \(q\in (0,1], \quad m(t),p(t),g(x),c,b,a,\tau _{1}\) and \(\tau _{2} \) have the same meanings as those defined in (2.3), and the notation \(D^{q}\) is chosen as the Caputo fractional derivative (2.1).
Obviously, when \(q=1\), network (2.4) degenerates to network (2.3). (\(m^{*},p^{*})\) is an equilibrium point of the fractional-order genetic regulatory network (2.4) if and only if
Clearly, network (2.3) and (2.4) possess the same equilibrium point.
3 Stability and Bifurcation Analysis
In this section, we investigate the stability of the fractional-order genetic regulatory network (2.4), then some conditions of Hopf bifurcations are established.
Let \(x(t)=m(t)-m^{*},y(t)=p(t)-p^{*}\). Then the linearized network (2.4) is:
with the characteristic equation:
That is:
where
In the following, the total delay \(\tau \) is regarded as the bifurcation parameter to investigate the distribution of roots of the characteristic equation (3.3).
Let \(s=\omega (\cos \frac{\pi }{2}+i\sin \frac{\pi }{2})(\omega >0)\). Then (3.3) becomes
Separating the real and imaginary parts gives
where
It can be obtained from (3.4) that
Hence
where
Denote
The following lemma examines the distribution of the roots of the characteristic equation (3.3).
Lemma 3.1
For (3.3), the following results hold:
-
i)
If \(D_k >0,k=1,2,3,4,A_2 -A_3 \ne 0\) , then (3.3) has no root with zero real parts for all \(\tau \ge 0.\)
-
ii)
If \(D_4 <0,\) and \(D_k >0,k=1,2,3,\) then (3.3) has a pair of purely imaginary roots \(\pm \, \omega _0\) when \(\tau =\tau _j , \quad j=0,1,\ldots ,\) where
in which \(\omega _0 \) is the unique positive zero of the function \(h(\omega )\).
Proof
-
i)
From \(D_k >0,k=1,2,3,4,\)we can derive
$$\begin{aligned} h(0)=D_4 >0, \end{aligned}$$and
$$\begin{aligned} {h}'(\omega )=4q\omega ^{4q-1}+D_1 3q\omega ^{3q-1}+D_2 2q\omega ^{2q-1}+D_3 q\omega ^{q-1}>0,\quad { for }\;\omega >0. \end{aligned}$$Combining \(q>0\) and \(D_k >0,k=1,2,3,4,\)we claim that (3.6) has no real root, and hence (3.3) has no purely imaginary root. Provided that \(A_2 -A_3 \ne 0,\lambda =0\)is not a root of (3.3). This ends the proof of i).
-
ii)
By means of \(D_4 <0,\) it is easy to see that \(h(0)=D_4 <0.\) By \(\mathop {\lim }\nolimits _{\omega \rightarrow +\infty } h(\omega )=+\infty ,\) and \({h}'(\omega )>0\) for \(\omega >0,\)there exists a unique positive number \(\omega _0 \) such that \(h(\omega )=0.\) Then \(\omega _0 \) is a root of (3.6). Hence, for \(\tau _j \) as defined in (3.7), \((\omega _0 ,\tau _j )\) is a root of (3.4). It can be seen that \(\pm \, \omega _0 \) is a pair of purely imaginary roots of (3.3) when \(\tau =\tau _j ,j=0,1,\ldots \). This completes the proof of ii). \(\square \)
To derive the transversality condition of the Hopf bifurcation, we make the following hypothesis:
where
Lemma 3.2
Let \(s(\tau )=\varsigma (\tau )+i\omega (\tau )\) be the root of system (3.3) near \(\tau =\tau _{j}\) satisfying \(\varsigma (\tau _j )=0, \quad \omega (\tau _{j} )=\omega _0\). If \(H_{1} \) holds, then we have
Proof
Differentiating (3.3) implicitly with respect to \(\tau \), we obtain
Hence, from (3.8), we deduce that
Obviously, the hypothesis \((H_1 )\) implies that transversality condition is satisfied. This ends the proof. \(\square \)
Theorem 3.3
For the fractional-order genetic regulatory network (2.4), the following results hold:
-
i)
If \(D_4 <0,D_k>0,k=1,2,3,A_2 -A_3 >0,\) and \(A_1 >0\), then the equilibrium \((m^{*},p^{*})\) of network (2.4) is locally asymptotically stable for \(\tau \in [0,\tau _0 ),\) and unstable when \(\tau >\tau _0\) .
-
ii)
If all the conditions as stated in (ii) hold, then network (2.4) undergoes a Hopf bifurcation at \((m^{*},p^{*}) \) when \(\tau =\tau _j , \quad j=0,1,\ldots ,\) where \(\tau =\tau _j \) as defined in (3.7).
Proof
Observing that when \(\tau =0\), the characteristic equation (3.3) becomes:
-
i)
According to the fractional Routh–Hurwitz criterion, it is easy to see that all the roots of (3.9) have negative real parts when \(A_2 -A_3 >0,\) and \(A_1 >0\). From the conclusion ii) of Lemma 3.1, the definition of \(\tau _0 \) implies that all the roots of (3.3) have negative real parts for \(\tau \in [0,\tau _0 )\). The conclusion in Lemma 3.2 indicates that (3.3) has at least a root with positive real parts when \(\tau >\tau _0 \). Hence, the conclusion i) holds.
-
ii)
The conclusion in Lemma 3.2 implies that the transversality condition for Hopf bifurcations is satisfied under the given assumption. So the Hopf bifurcation occurs at \(\tau =\tau _j \),\(j=0,1,\ldots \). We complete the proof of Theorem 3.3. \(\square \)
4 Simulation Examples
In this section, we present some numerical results to illustrate the analytical results obtained in the previous section, and display the Hopf bifurcation phenomenon of the delayed fractional-order model (2.4) of genetic regulatory networks.
We choose the same parameters used in [34]: \(a=5,b=2,c=1.5,g(x)=4/{(1+x^{2}),}\) and the fractional order is chosen as \(q=0.92\), then system (enumerate) becomes:
which has a positive equilibrium \((m^{*},p^{*})=(0.6822,1.7055).\) From (3.7), we can obtain \(\tau _0 =2.1585\). From Theorem 3.3, the positive equilibrium point (\(m^{*},p^{*})\) of the fractional-order genetic regulatory network (2.4) is asymptotically stable when \(\tau =2.1<\tau _0 =2.1585\) as illustrated in Figs. 1 and 2. When \(\tau =2.3>\tau _0 =2.1585,\) the positive equilibrium point \((m^{*},p^{*})\) of the fractional-order genetic regulatory network (2.4) becomes unstable, and a Hopf bifurcation occurs, as shown in Figs. 3 and 4.
When we choose \(q=0.8,\) it can be obtained from (3.7) that \(\tau _0 =3.2449.\) The positive equilibrium point \((m^{*},p^{*})\)is asymptotically stable when \(\tau =3.0<\tau _0 =3.2499\) as illustrated in Figs. 5 and 6. When \(\tau =3.4>\tau _0 =3.2449,\) the positive equilibrium point \((m^{*},p^{*})\)becomes unstable, and a Hopf bifurcation occurs, as shown in Figs. 7 and 8.
The effect of the order q on the values of \(\tau _0 \) and \(\omega _0 \) for network (2.4) is shown in Table 1 and Fig. 9. It is found that the critical value \(\tau _0 \) decreases clearly with the order q, which means that the value of \(\tau _0 \) is sensitive to the change of the order q.
5 Conclusions
In this paper, we have extended a delayed factional-order model of genetic regulatory networks, and have considered the stability and bifurcations of the network. A stability criterion has been established, and some conditions of Hopf bifurcations have been proposed for the delayed fractional-order genetic network model. The delayed fractional-order genetic network model may generate a Hopf bifurcation (i.e., periodic oscillations appear) as the total delay passes through some critical values which can be determined exactly. It is observed that an increase in the order may lead to a decrease of the critical value of delay. The observations allow us to design the Hopf bifurcation with the desired bifurcation point by adjusting the delays and the order for genetic networks. It should be pointed out that the method proposed in this paper can be extended to deal with the bifurcation of 3-dimensional or multidimensional fractional-order systems.
It has been demonstrated by experimental evidence that small RNAs play crucial roles in the regulation and control of genetic events [35]. Thus, our future work will incorporate small RNAs and other small molecules into gene expressions to establish more accurate models and then address the effect of small RNAs on dynamics of gene regulatory networks. On the other hand, we will adopt a fractional-order Proportion-Integral-Derivative scheme to control the bifurcation embedded in fractional-order genetic regulatory networks.
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Acknowledgements
This work is supported by National Natural Science Foundation of China (No. 61573194), Six Talent Peaks High Level Project of Jiangsu Province (2014-ZNDW-004) and Science Foundation of Nanjing University of Posts and Telecommunications (NY213095).
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Sun, Q., Xiao, M. & Tao, B. Local Bifurcation Analysis of a Fractional-Order Dynamic Model of Genetic Regulatory Networks with Delays. Neural Process Lett 47, 1285–1296 (2018). https://doi.org/10.1007/s11063-017-9690-7
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DOI: https://doi.org/10.1007/s11063-017-9690-7