Abstract
Malignant carcinomatous change is a rare complication in an enteric duplication cyst, and papillary adenocarcinoma is especially unusual. We describe a papillary adenocarcinoma, arising from a duplication of the colon, seen as a cyst with an enhancing papillary projection nodule located adjacent to the wall of the ascending colon and cecum on computed tomography.
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Duplications of the alimentary tract are unusual developmental anomalies that may occur anywhere in the gastrointestinal tract. They are usually located in, or adjacent to, the wall of part of the bowel; additionally, they have smooth muscle in their walls, and are lined by mucosa similar to that of the adjacent segment of the digestive tube [1, 2]. Such a developmental anomaly is most common in the ileum, followed by the esophagus and duodenum, but less frequent in the colon or rectum. Malignant change in an intestinal duplication is extremely rare, and occurs most often in the colon. Adenocarcinoma is the most common histological type of malignancy arising in an intestinal duplication. Papillary adenocarcinoma is extremely rare, and the only reported case was in the small bowel [3]. We present the first case of papillary adenocarcinoma arising in colon duplication.
Case report
A 40-year-old woman complained of a palpable abdominal mass that she first noticed 3 weeks before admission. On physical examination, there were no positive findings except for a palpable mass in the right periumbilical area. The laboratory data were normal, except for a high serum carcinoembryonic antigen (CEA) level of 10.59 ng/mL.
The abdomen supine film showed a round mass density in the right lower abdomen that displaced the ascending colon superiorly and the small bowel loops medially. Enhanced abdomen computed tomography (CT) showed a 11.0 × 8.3 × 10.0 cm, round, sharply marginated, thin-walled cystic mass in the right lower abdomen displacing the ascending colon superiorly and the distal ileal loop inferomedially, so that it was located just inferior to the proximal ascending colon (Fig. 1A, B). The cystic mass contained a 4.0 × 4.4 × 4.5 cm lobulated nodule. The fluid component was homogenous low density, while the nodules enhanced homogenously with contrast. An enlarged vascular structure was seen on the posterolateral side of the cystic mass. This was the ileocolic branch of the superior mesenteric artery, which supplied the lesion. There were a few regional lymph nodes, ranging from 0.5 to 1.0 cm in size, around the cystic mass. Normal looking ovaries, uterus, and appendix were seen in situ. No small or large bowel invasion, bowel obstruction, or vascular encasement was evident. Colonoscopy revealed a normal mucosal layer throughout the colon, but an intraluminal protruding mass near the proximal ascending colon and cecum.
Given the characteristics of the mass, including the pattern of enhancement and its location, the high serum CEA, and its proximity to the colon and mesentery, the differential diagnosis consisted of a complicated mesenteric cyst, a gastrointestinal stromal tumor (GIST), or an intestinal duplication cyst arising from the cecum or ascending colon with a high probability of malignancy.
A right hemicolectomy was done. At surgery, a huge, well-encapsulated, cystic mass was found abutting the normal cecum and mesentery (Fig. 1C). No ascites, adhesion, or seeding were evident. A few small lymph nodes 0.5–1.0 cm in size were seen in the mesentery around the mass. The cystic fluid was dark brown, but not sticky, representing hemorrhagic fluid. There was some sludge from the growing papillary mass within the cyst. Histologic examination of the surgical specimen revealed a papillary adenocarcinoma with micro-invasion of the muscle layer of the cecum arising within an intestinal duplication cyst of the cecum (Fig. 1D).
On immunohistochemical staining, CDX2 and CK20 stained strongly, while CK7 was negative in the papillary adenocarcinoma, which represented an adenocarcinoma arising from the colon (Fig. 1E, F). The cyst consisted of well-organized layers of smooth muscle, typical of the colon, and lined by benign epithelium of columnar cells. There were no metastatic lymph nodes, but reactive lymph node hyperplasia.
Discussion
Malignant carcinomatous change in a duplication of the gastrointestinal tract is rare in adults, but has been well documented in the English literature [4–10]. In our survey, most of the reported cases were located in the colon, followed by the small bowel, stomach, and intrathoracic cavity. Various malignancies have been reported in enteric duplications, including adenocarcinoma, squamous cell carcinoma, and carcinoid tumor. Papillary adenocarcinoma was extremely rare, with the only reported case in a small bowel duplication [3]. We described the first case of papillary adenocarcinoma in a duplication of the colon.
Primary papillary adenocarcinoma is a rare histologic subtype of adenocarcinoma of the colon, but it frequently occurs in the ovary, pancreas, and thyroid. The pathologist reported papillary adenocarcinoma when the soft tissue density nodule showed a papillary configuration consisting of fibrovascular cores. Given the rarity of primary papillary adenocarcinoma of the colon, the differential diagnosis should include metastatic carcinoma, such as papillary adenocarcinoma of the ovary, uterus, pancreas, and head and neck. In order to rule out these tumors, detection of an intramucosal component to the carcinoma and the normal appearance of these organs are important. Immunohistochemical staining using CK20, CDX2, and CK7 has been reported to be useful in distinguishing adenocarcinoma arising from colon mucosa from that in other organs [11–13]. We used CK20, CDX2, and CK7 to exclude metastatic papillary adenocarcinoma from other organs, because the CK20+/CDX2+/CK7− immunohistochemical staining pattern is usually retained in primary and metastatic adenocarcinoma of the colon. Our case of papillary adenocarcinoma in a colonic duplication cyst was CDX2+/CK20+/CK7−, which is typical of colonic cancer, not metastasis from other organs.
Radich et al. [3] described magnetic resonance findings in one case of papillary adenocarcinoma in a small bowel duplication, which consisted of a sharply marginated, thin-walled cystic mass with internal multiple dependent and nondependent lobulated nodules. The fluid component was hyperintense on T1- and hypointense on T2-weighted images, representing hemorrhage. The nodules were hypointense on T1- and increased in signal intensity on T2-weighted images, representing carcinoma.
Our case had similar CT findings. We described the CT findings as a sharply marginated, fluid-filled cyst with a lobulated, enhancing soft tissue nodule located adjacent to the wall of the colon. We did not see any calcifications (so-called psammoma bodies) in the mass; these can be seen in papillary adenocarcinoma arising from any body site. Histologically, our case did not contain mucin within the cyst, making it a non-mucin producing papillary adenocarcinoma. Initially, we did not diagnose the tumor as papillary adenocarcinoma, but only as a malignant cystic mass arising from a mesenteric cyst, duplication cyst, or unusual GIST, based on previous reports describing malignant cystic masses as soft-tissue-density nodules revealed within the cyst [4, 9]. Based on the high CEA level, we strongly suspected an adenocarcinoma arising within a duplication cyst of the colon.
In conclusion, if a large cystic mass is located in or adjacent to the alimentary tract, one should include enteric duplication cyst in the differential diagnosis. Other cystic masses are mesenteric and omental cysts, pancreatic pseudocysts, renal or splenic cysts, ovarian cysts, or loculated ascites. When a lobulated nodule is seen within the cyst and the serum CEA level is high, the possibility of papillary adenocarcinoma should be considered.
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Lee, J., Jeon, Y.H. & Lee, S. Papillary adenocarcinoma arising in a duplication of the cecum. Abdom Imaging 33, 601–603 (2008). https://doi.org/10.1007/s00261-007-9330-1
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DOI: https://doi.org/10.1007/s00261-007-9330-1