Abstract
Sulphadimidine (SDM), a drug frequently administered to pigs, is partially converted into other compounds by processing meat to produce raw, fermented sausage. With the aid of 14C-labelled SDM, evidence was obtained that part of the radioactive matter was covalently bound to the matrix. Part of these bound residues could be released in vitro by 4 M HCl at 21 °C or by 0.024 M HCl at 37 °C. Female rats were also able to release bound SDM residues and to excrete these in their urine, in amounts approaching those obtained by treatment with 4 M HCl. Both the parent compound and its main metabolite, N 4-acetyl-SDM, were observed in the urine of rats.
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Received: 29 December 1997 / Revised version: 20 February 1998
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Smit, L., Haagsma, N. & Ruiter, A. Bound sulphadimidine residues in raw fermented sausage: release under acidic conditions and bioavailability in rats. Z Lebensm Unters Forsch 208, 183–188 (1999). https://doi.org/10.1007/s002170050399
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DOI: https://doi.org/10.1007/s002170050399