Summary
D-Cysteinolic acid (1) analogues with an S-C-C-N skeleton showed increased platelet anti-aggregant activity in the following order: 2-aminoethanesulfonic acids, thiazolidines, 2-aminoethanethiols and 2-aminoethyl disulfides. Methyl substitutions at the 2-position potentiated the activity. Of these analogues, bis [(R)-2-aminopropyl] disulfide was the most potent inhibitor of platelet aggregation, with about 600-fold the activity of (1).
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Satake, M., Chiba, Y., Kohama, Y. et al. Comparative platelet anti-aggregant activity of D-cysteinolic acid analogues. Experientia 45, 1110–1112 (1989). https://doi.org/10.1007/BF01950172
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DOI: https://doi.org/10.1007/BF01950172