Abstract
Phospholipids and Emasol activate cytochrome oxidase by increasing its affinity for its substrate, cytochromec. Cardiolipin was most effective in activating cytochrome oxidase among phospholipids tested. Prior formation of a cytochromec-cytochrome oxidase complex changes the effect of phospholipids. In addition to their structural role in the last segment of the electron transport system, phospholipids can protect the enzyme from heat treatment and mercurial inhibition. They facilitate the interaction between cytochrome oxidase and cytochromec, as well as the cytochromec analogue, protamine.
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Chuang, T.F., Crane, F.L. Phospholipids in the cytochrome oxidase reaction. J Bioenerg Biomembr 4, 563–578 (1973). https://doi.org/10.1007/BF01516208
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DOI: https://doi.org/10.1007/BF01516208