Abstract
In this section of the journal, the literature on continuous-flow synthesis (primarily organic synthesis and functional materials) from the period of July to September 2015 is presented. All the publications are listed and ordered by journal name, with a few review articles appearing at the end. With a few special issues related to flow synthesis and advances in organic process development, the number of publications on flow synthesis has grown steadily in this period. This also shows the growing interest of the community in adapting to flow synthesis.
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“Translating the enantioselective michael reaction to a continuous flow paradigm with an immobilized, fluorinated organocatalyst” I. Sagamanova, C. Rodrïguez-Escrich, I. G. Molnár, S. Sayalero, R. Gilmour, M. A. Pericàs ACS Catalysis 2015, 5, 6241–6248
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“One-pot reductive amination of aldehydes with nitroarenes over an Au/Al2O3 catalyst in a continuous flow reactor” E. A. Artiukha, A. L. Nuzhdin, G. A. Bukhtiyarova, S. Y. Zaytsev, P. E. Plyusnin, Y. V. Shubin, V. I. Bukhtiyarov Catalysis Science & Technology 2015, 5, 4741–4745
“Continuous poly (2-oxazoline) triblock copolymer synthesis in a microfluidic reactor cascade” E. Baeten, B. Verbraeken, R. Hoogenboom, T. Junkers Chemical Communications 2015, 51, 11701–11704
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“Simultaneous solvent screening and reaction optimization in microliter slugs” B. J. Reizman, K. F. Jensen Chemical Communications 2015, 51, 13290–13293
“Continuous synthesis of methanol: heterogeneous hydrogenation of ethylene carbonate over Cu/HMS catalysts in a fixed bed reactor system” X. Chen, Y. Cui, C. Wen, B. Wang, W. L. Dai Chemical Communications 2015, 51, 13776–13778
“Continuous flow synthesis of a carbon-based molecular cage macrocycle via a three-fold homocoupling reaction” M. Kitchin, K. Konstas, C. J. Sumby, M. L. Czyz, P. Valente, M. R. Hill, C. J. Doonan Chemical Communications 2015, 51, 14231–14234
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“Continuous synthesis and thermal elimination of sulfinyl-route poly (p-phenylene vinylene) in consecutive flow reactions” N. Zaquen, E. Baeten, J. Vandenbergh, L. Lutsen, D. Vanderzande, T. Junkers Chemical Engineering & Technology 2015, 38, 1749–1757
“Effect of process parameters on properties of colloids in a continuous-flow microreactor system” S. H. Sonawane, M. L. Bari, Suryawanshi, J. S. Narkhede, S. Mishra, B. A. Bhanvase Chemical Engineering & Technology 2015, 38, 1765–1773
“Continuous flow polymer synthesis toward reproducible large-scale production for efficient bulk heterojunction organic solar cells” G. Pirotte, J. Kesters, P. Verstappen, S. Govaerts, J. Manca, L. Lutsen, W. Maes ChemSusChem 2015, 8, 3228–3233
“Gas–liquid segmented flow microwave-assisted synthesis of MOF-74 (Ni) under moderate pressures” G. H. Albuquerque, R. C. Fitzmorris, M. Ahmadi, N. Wannenmacher, P. K. Thallapally, B. P. McGrail, G. S. Herman CrystEngComm 2015, 17, 5502–5510
“Continuous synthesis of dispersant-coated hydroxyapatite plates” M. Gimeno-Fabra, F. Hild, P. W. Dunne, K. Walton, D. M. Grant, D. J. Irvine, E. H. Lester CrystEngComm 2015, 17, 6175–6182
“Nucleation studies of active pharmaceutical ingredients in an air-segmented microfluidic drop-based crystallizer” J. Lu, J. D. Litster, Z. K. Nagy Crystal Growth & Design 2015, 15, 3645–3651
“Nucleation and growth of cobalt oxide nanoparticles in a continuous hydrothermal reactor under laminar and turbulent flow” C. J. Denis, C. J. Tighe, R. I. Gruar, N. M. Makwana, J. A. Darr Crystal Growth & Design 2015, 15, 4256–4265
“Continuous spherical crystallization of albuterol sulfate with solvent recycle system” K. Tahara, M. O’Mahony, A. S. Myerson Crystal Growth & Design 2015, 15, 5149–5156
“Pilot-scale fluidized-bed co-gasification of palm kernel shell with sub-bituminous coal” C. F. Valdés, G. Marrugo, F. Chejne, J. I. Montoya, C. A. Gómez Energy & Fuels 2015, 29, 5894–5901
“Hydrothermal liquefaction of microalgae in a continuous stirred-tank reactor” D. López Barreiro, B. Ríos Gómez, U. Hornung, A. Kruse, W. Prins Energy & Fuels 2015, 29, 6422–6432
“Automated serendipity with self-optimizing continuous-flow reactors” Z. Amara, E. S. Streng, R. A. Skilton, J. Jin, M. W. George, M. Poliakoff European Journal of Organic Chemistry 2015, 2015, 6141–6145
“Influence of microphase morphology and long-range ordering on foaming behavior of PE-b-PEO diblock copolymers” Y. Xu, T. Liu, W.-k. Yuan, L. Zhao Industrial & Engineering Chemistry Research 2015, 54, 7113–7121
“Insights into the Diels–Alder reactions between cyclopentadiene and 1, 3-butadiene with high temperature and high pressure” K. Cao, X. Liu, Y. Zhang, J.-l. Shi, Y.-x. Song, Z. Yao Industrial & Engineering Chemistry Research 2015, 54, 7565–7570
“Enzymatic fatty acid hydroxylation in a liquid–liquid slug flow microreactor” I. Iliuta, A. Garnier, M. C. Iliuta Industrial & Engineering Chemistry Research 2015, 54, 7787–7799
“Development of a dual-stage continuous flow reactor for hydrothermal synthesis of hybrid nanoparticles” H. L. Hellstern, J. Becker, P. Hald, M. Bremholm, A. Mamakhel, B. B. Iversen Industrial & Engineering Chemistry Research 2015, 54, 8500–8508
“A Tandem, bicatalytic continuous flow cyclopropanation-homo-Nazarov-type cyclization” J. Aponte-Guzmán, R. Shenje, Y. Huang, W. H. Woodham, S. R. Saunders, S. M. Mostaghimi K. R. Flack, P. Pollet, C. A. Eckert, C. L. Liotta, S. France Industrial & Engineering Chemistry Research 2015, 54, 9550–9558
“Heterocyclization approach for electrooxidative coupling of functional primary alkylamines with aromatics” T. Morofuji, A. Shimizu, Jun-ichi Yoshida Journal of the American Chemical Society 2015, 137, 9816–9819
“Recent advances in continuous rhodium-catalyzed hydroformylation” X. Wang Journal of Flow Chemistry 2015, 5, 125–132
“Continuous-flow synthesis and purification of atropine with sequential in-line separations of structurally similar impurities” C. Dai, D. R. Snead, P. Zhang, T. F. Jamison Journal of Flow Chemistry 2015, 5, 133–138
“Rapid-flow synthesis of Zn–Qn complexes: teaching old ligands new tricks with reactive Na2(HZnEt2)2” L. Z. Miller, J. J. Hrudka, Y. R. Naro, M. Haaf, M. Shatruk, D. T. McQuade Journal of Flow Chemistry 2015, 5, 139–141
“Efficient continuous-flow synthesis of macrocyclic triazoles” A. Bédard, J. Santandrea, S. K. Collins Journal of Flow Chemistry 2015, 5, 142–144
“A flow-based synthesis of telmisartan” A. D. Martin, A. R. Siamaki, K. Belecki, B. F. Gupton Journal of Flow Chemistry 2015, 5, 145–147
“The preparation of ethyl levulinate facilitated by flow processing: the catalyzed and uncatalyzed esterification of levulinic acid” M. P. Negus, A. C. Mansfield, N. E. Leadbeater Journal of Flow Chemistry 2015, 5, 148–150
“Protein and antibody functionalization using continuous flow microreactor technology” M. M. Sebeika, N. G. Gedeon, Sadler, N. L. Kern, D. J. Wilkins, D. E. Bell, G. B. Jones Journal of Flow Chemistry 2015, 5, 151–154
“Development of a photolabile amine protecting group suitable for multistep flow synthesis” H. Yueh, A. Voevodin, Beeler Journal of Flow Chemistry 2015, 5, 155–159
“Mass transfer characteristics of ozonolysis in microreactors and advanced-flow reactors” M. J. Nieves-Remacha, K. F. Jensen Journal of Flow Chemistry 2015, 5, 160–165
“When solids stop flow chemistry in commercial tubing” Y. Chen, J. C. Sabio, R. L. Hartman Journal of Flow Chemistry 2015, 5, 166–171
“An efficient and more sustainable one-step continuous-flow multicomponent synthesis approach to chromene derivatives” B. Reddy Vaddula, S. Yalla, M. A. Gonzalez Journal of Flow Chemistry 2015, 5, 172–177
“Microreactor flow synthesis of the secondary high explosive 2,6-diamino-3,5-dinitropyrazine-1-oxide (LLM-105)” N. B. Zuckerman, M. Shusteff, P. F. Pagoria, A. E. Gash Journal of Flow Chemistry 2015, 5, 178–182
“Moffat–Swern oxidation of alcohols: translating a batch reaction to a continuous-flow reaction” O. Bleie, M. F. Roberto, T. I. Dearing, C. W. Branham, O. M. Kvalheim, B. J. Marquardt Journal of Flow Chemistry 2015, 5, 183–189
“Continuous processing of active pharmaceutical ingredients suspensions via dynamic cross-flow filtration” J. Gursch, R. Hohl, G. Toschkoff, D. Dujmovic, J. Brozio, M. Krumme, J. Khinast Journal of Pharmaceutical Sciences 2015, 104, 3481–3489
“Continuous flow synthesis of poly (methyl methacrylate) via a light-mediated controlled radical polymerization” A. Melker, B. P. Fors, C. J. Hawker, J. E. Poelma Journal of Polymer Science Part A: Polymer Chemistry 2015, 53, 2693–2698
“LoMA-B: a simple and versatile lab-on-a-chip system based on single-channel bisulfate conversion for DNA methylation analysis” J. Yoon, M. K. Park, T. Y. Lee, Y. J. Yoon, Y. Shin Lab on a Chip 2015, 15, 3530–3539
“Continuous microwave flow synthesis (CMFS) of nanosized titania: structural, optical and photocatalytic properties” M. Akram, F. K. Butt, A. Z. Alshemary, Y.-F. Goh, W. A. W. Ibrahim, R. Hussain Materials Letters 2015, 158, 95–98
“Continuous microwave flow synthesis of mesoporous hydroxyapatite” M. Akram, A. Z. Alshemary, Y.-F. Goh, W. A. W. Ibrahim, H. O. Lintang, R. Hussain Materials Science and Engineering: C 2015, 56, 356–362
“Copper-catalysed azide–alkyne cycloadditions (CuAAC): an update” E. Haldón, M. C. Nicasio, P. J. Pérez Organic & Biomolecular Chemistry 2015, 13, 9528–9550
“Visible-light photoredox catalysis: direct synthesis of fused ß-carbolines through an oxidation/[3 + 2] cycloaddition/oxidative aromatization reaction cascade in batch and flow microreactors” D. Chandrasekhar, S. Borra, J. S. Kapure, G. S. Shivaji, G. Srinivasulu, R. A. Maurya Organic Chemistry Frontiers 2015, 2, 1308–1312
“Generation and ring opening of aziridines in telescoped continuous flow processes” N. Hsueh, G. J. Clarkson, M. Shipman Organic Letters 2015, 17, 3632–3635
“Homogeneous gold-catalyzed glycosylations in continuous flow” S. Matthies, D. T. McQuade, P. H. Seeberger Organic Letters 2015, 17, 3670–3673
“Domino hydrogenation–reductive amination of phenols, a simple process to access substituted cyclohexylamines” V. R. Jumde, E. Petricci, C. Petrucci, N. Santillo, M. Taddei, L. Vaccaro Organic Letters 2015, 17, 3990–3993
“Intensified co-oligomerization of propylene oxide and carbon dioxide in a continuous heat exchanger loop reactor at elevated pressures” J. Langanke, A. Wolf Organic Process Research & Development 2015, 19, 735–739
“Continuous-flow synthesis of meta-substituted phenol derivatives” J. H. Park, C. Y. Park, M. J. Kim, M. U. Kim, Y. J. Kim, G.-H. Kim, C. P. Park Organic Process Research & Development 2015, 19, 812–818
“Investigating scale-up and further applications of DABAL-Me3 promoted amide synthesis” D. S. Lee, Z. Amara, M. Poliakoff, T. Harman, G. Reid, B. Rhodes, S. Brough, T. McInally, S. Woodward Organic Process Research & Development 2015, 19, 831–840
“PTFE-membrane flow reactor for aerobic oxidation reactions and its application to alcohol oxidation” J. F. Greene, Y. Preger, S. S. Stahl, T. W. Root Organic Process Research & Development 2015, 19, 858–864
“Exceptionally stable and efficient solid supported Hoveyda-type catalyst” K. Skowerski, J. Pastva, S. J. Czarnocki, J. Janoscova Organic Process Research & Development 2015, 19, 872–877
“Continuous-flow process for the synthesis of 2-ethylphenylhydrazine hydrochloride” Z. Yu, G. Tong, X. Xie, P. Zhou, Y. Lv, W. Su Organic Process Research & Development 2015, 19, 892–896
“Development of a continuous flow sulfoxide imidation protocol using azide sources under superacidic conditions” B. Gutmann, P. Elsner, A. O’Kearney-McMullan, W. Goundry, D. M. Roberge, C. O. Kappe Organic Process Research & Development 2015, 19, 1062–1067
“Continuous-flow nitration of o-xylene: effect of nitrating agent and feasibility of tubular reactors for scale-up” Y. Sharma, R. A. Joshi, A. A. Kulkarni Organic Process Research & Development 2015, 19, 1138–1147
“Oscillatory flow reactors (OFRs) for continuous manufacturing and crystallization” T. McGlone, N. E. B. Briggs, C. A. Clark, C. J. Brown, J. Sefcik, A. J. Florence Organic Process Research & Development 2015, 19, 1186–1202
“Development of pilot-scale continuous production of an LY2886721 starting material by packed-bed hydrogenolysis” N. Zaborenko, R. J. Linder, T. M. Braden, B. M. Campbell, M. M. Hansen, M. D. Johnson Organic Process Research & Development 2015, 19, 1231–1243
“Polymerization of vinyl ethers initiated by dendritic cations using flow microreactors” A. Nagaki, M. Takumi, Y. Tani, and Jun-ichi Yoshida Tetrahedron, 2015, 71, 5973–5978
“Study for diastereoselective aldol reaction in flow: synthesis of (E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid, a key component of cyclodepsipeptide HDAC inhibitors” T. Doi, H. Otaka, K. Umeda, M. Yoshida Tetrahedron 2015, 71, 6463–6470
“Continuous flow reactions in water for the synthesis of propargylamines via a metal-free decarboxylative coupling reaction” B. Jung, K. Park, K. H. Song, S. Lee Tetrahedron Letters 2015, 56, 4697–4700
“Pyrolysis of cyclopentadienone: mechanistic insights from a direct measurement of product branching ratios” T. K. Ormond, A. M. Scheer, M. R. Nimlos, D. J. Robichaud, T. P. Troy, M. Ahmed, J. W. Daily, T. L. Nguyen, J. F. Stanton, G. B. Ellison The Journal of Physical Chemistry A 2015, 119, 7222–7234
“Experimental and modeling investigation of the low-temperature oxidation of dimethyl ether” A. Rodriguez, O. Frottier, O. Herbinet, R. Fournet, R. Bounaceur, C. Fittschen, F. Battin-Leclerc The Journal of Physical Chemistry A 2015, 119, 7905–7923
“Influence of He and Ar flow rates and NaCl concentration on the size distribution of bubbles generated by power ultrasound” R. Pflieger, J. Lee, S. I. Nikitenko, M. Ashokkumar The Journal of Physical Chemistry B 2015, 119, 12682–12688
“Impact of deactivation phenomena on kinetics of the C–N coupling reaction over supported Cu2O catalysts in continuous-flow conditions” B. Jurca, A. Tirsoaga, P. Granger, V. I. Parvulescu The Journal of Physical Chemistry C 2015, 119, 18422–18433
“Continuous and discontinuous dynamic crossover in supercooled water in computer simulations” Z. Ma, J. Li, F. Wang The Journal of Physical Chemistry Letters 2015, 6, 3170–3174
“The synthesis of cadmium sulfide nanoplatelets using a novel continuous flow sonochemical reactor” B. Palanisamy, B. Paul, C.-h. Chang Ultrasonics Sonochemistry 2015, 26, 452–460
Nanomaterials
“MnOx nanoparticle-dispersed CeO2 nanocubes: a remarkable heteronanostructured system with unusual structural characteristics and superior catalytic performance” S. Putla, M. H. Amin, B. M. Reddy, A. Nafady, K. A. A. Farhan, S. K. Bhargava ACS Applied Materials & Interfaces 2015, 7, 16525–16535
“Interference-free micro/nanoparticle cell engineering by use of high-throughput microfluidic separation” D. C. Yeo, C. Wiraja, Y. Zhou, H. M. Tay, C. Xu, H. W. Hou ACS Applied Materials & Interfaces 2015, 7, 20855–20864
“Flow effects on the controlled growth of nanostructured networks at microcapillary walls for applications in continuous flow reactions” G. Wang, C. Yuan, B. Fu, L. He, E. Reichmanis, H. Wang, Q. Zhang, Y. Li ACS Applied Materials & Interfaces 2015, 7, 21580–21588
“Strong carbon nanotube fibers by drawing inspiration from polymer fiber spinning” B. Alemán, V. Reguero, B. Mas, J. J. Vilatela ACS Nano 2015, 9, 7392–7398
“Synthesis of nickel nanoparticles by aqueous reduction in continuous flow microreactor” L. Xu, C. Srinivasakannan, J. Peng, D. Zhang, G. Chen Chemical Engineering and Processing: Process Intensification 2015, 93, 44–49
“Oscillatory microprocessor for growth and in situ characterization of semiconductor nanocrystals” M. Abolhasani, C. W. Coley, L. Xie, O. Chen, M. G. Bawendi, K. F. Jensen Chemistry of Materials 2015, 27, 6131–6138
“Effect of seed age on gold nanorod formation: a microfluidic, real-time investigation” J. Watt, B. G. Hance, R. S. Anderson, D. L. Huber Chemistry of Materials 2015, 27, 6442–6449
“Hydrothermal synthesis and in situ powder X-ray diffraction study of bismuth-substituted ceria nanoparticles” K. Houlberg, E. D. Bøjesen, C. Tyrsted, A. Mamakhel, X. Wang, R. Su, F. Besenbacher, B. B. Iversen Crystal Growth & Design 2015, 15, 3628–3636
“Highly oxidized multifunctional organic compounds observed in tropospheric particles: a field and laboratory study” A. Mutzel, L. Poulain, T. Berndt, Y. Iinuma, M. Rodigast, O. Bóge, S. Richters, Spindler, M. Sipilá, T. Jokinen, M. Kulmala, H. Herrmann Environmental Science & Technology 2015, 49, 7754–7761
“Phosphate detection through a cost-effective carbon black nanoparticle-modified screen-printed electrode embedded in a continuous flow system” D. Talarico, S. Cinti, F. Arduini, A. Amine, D. Moscone, G. Palleschi Environmental Science & Technology 2015, 49, 7934–7939
“An ultrahigh precision, high-frequency dissolved inorganic carbon analyzer based on dual isotope dilution and cavity ring-down spectroscopy” K. Huang, N. Cassar, B. Jonsson, W.-j. Cai, M. L. Bender Environmental Science & Technology 2015, 49, 8602–8610
“Selective enrichment establishes a stable performing community for microbial electrosynthesis of acetate from CO2” S. A. Patil, J. B. A. Arends, I. Vanwonterghem, J. V. Meerbergen, K. Guo, G. W. Tyson, K. Rabaey Environmental Science & Technology 2015, 49, 8833–8843
“A direct and continuous supercritical water process for the synthesis of surface-functionalized nanoparticles” R. I. Gruar, C. J. Tighe, P. Southern, Q. A. Pankhurst, J. A. Darr Industrial & Engineering Chemistry Research 2015, 54, 7436–7451
“Development of a dual-stage continuous flow reactor for hydrothermal synthesis of hybrid nanoparticles” H. L. Hellstern, J. Becker, P. Hald, M. Bremholm, Mamakhel, B. B. Iversen Industrial & Engineering Chemistry Research 2015, 54, 8500–8508
“Structural and optical characterization of CuInS2 quantum dots synthesized by microwave-assisted continuous flow methods” R. C. Fitzmorris, R. P. Oleksak, Z. Zhou, B. D. Mangum, J. N. Kurtin, G. S. Herman Journal of Nanoparticle Research 2015, 17, 1–10
“Continuous flow formulation and functionalization of magnesium di-hydroxide nanorods as a clean nano-fire extinguisher” S. Elbasuney, S. F. Mostafa Powder Technology 2015, 278, 72–83
Reviews
“Machine-assisted organic synthesis” S. V. Ley, D. E. Fitzpatrick, Myers, C. Battilocchio, R. Ingham Angewandte Chemie International Edition 2015, 54, 10122–10136
“The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry” M. Baumann, I. R. Baxendale Beilstein Journal of Organic Chemistry 2015, 11, 1194–1219
“Nanocatalysis in flow” R. Ricciardi, J. Huskens, W. Verboom ChemSusChem 2015, 8, 2586–2605
“Photochemistry in flow” A. B. Beeler, S. R. Corning Photochemistry 2015, 43, 175
“Recent trends in using single-drop microextraction and related techniques in green analytical methods” J. M. Kokosa TrAC Trends in Analytical Chemistry 2015, 71, 194–204
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Kulkarni, A.A. Highlights from the Flow Chemistry Literature 2015 (Part 3). J Flow Chem 5, 241–247 (2015). https://doi.org/10.1556/1846.2015.00042
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DOI: https://doi.org/10.1556/1846.2015.00042