Abstract
In this section of the journal, the literature on continuous-flow synthesis (primarily organic synthesis and functional materials) from the period of April to June 2015 is presented. All the publications are listed and ordered by journal name, with a review article appearing at the end. With a few special issues on flow synthesis that would be appearing in other journals in coming months, the list of publications in this area is expected to grow rapidly towards the end of this year.
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Organic Synthesis
“High-throughput generation of emulsions and microgels in parallelized microfluidic drop-makers prepared by rapid prototyping” T. Femmer, A. Jans, R. Eswein, N. Anwar, M. Moeller, M. Wessling, A. J. C. Kuehne ACS Applied Materials & Interfaces 2015, 7, 12635–12638
“Magnetic droplet microfluidics as a platform for the concentration of [18 F]fluoride and radiosynthesis of sulfonyl [18 F]fluoride” S. A. Fiel, H. Yang, P. Schaffer, S. Weng, J. A. H. Inkster, M. C. K. Wong, P. C. H. Li ACS Applied Materials & Interfaces 2015, 7, 12923–12929
“A flow-through enzymatic microreactor for the rapid conversion of triacylglycerols into fatty acid ethyl ester and fatty acid methyl ester derivatives for GC analysis” S. T. Anuar, S. M. Mugo, J. M. Curtis Analytical Methods 2015, 7, 5898–5906
“Making ends meet: flow synthesis as the answer to reproducible high-performance conjugated polymers on the scale that roll-to-roll processing demands” M. Helgesen, J. E. Carlé, G. A. dos Reis Benatto, R. R. Sondergaard, M. Jorgensen, E. Bundgaard, F. C. Krebs Advanced Energy Materials 2015, 5
“Reactions of difunctional electrophiles with functionalized aryllithium compounds: remarkable chemoselectivity by flash chemistry” A. Nagaki, K. Imai, S. Ishiuchi, J. Yoshida Angew. Chem. Int. Ed. 2015, 54, 1914–1918
“Continuous synthesis of diethyl carbonate from ethanol and CO2 over Ce-Zr-O catalysts” I. Prymak, V. N. Kalevaru, S. Wohlrab, A. Martin Catalysis Science & Technology 2015, 5, 2322–2331
“Continuous poly(2-oxazoline) triblock copolymer synthesis in a microfluidic reactor cascade” E. Baeten, B. Verbraeken, R. Hoogenboom, T. Junkers Chemical Communications 2015, 51, 11701–11704
“Continuous synthesis of methanol: heterogeneous hydrogenation of ethylene carbonate over Cu/HMS catalysts in a fixed bed reactor system” X. Chen, Y. Cui, C. Wen, B. Wang, W-L. Dai Chemical Communications 2015, DOI: 10._1039/C5CC05030H
“Large-scale continuous hydrothermal production and activation of ZIF-8” A. S. Munn, P. W. Dunne, S. V. Y. Tang, E. H. Lester Chemical Communications 2015, 51, 12811–12814
“Continuous flow of nitroso Diels-Alder reaction” E. Nakashima, H. Yamamoto Chemical Communications 2015, 51, 12309–12312
“Decarboxylative Reissert type trifluoro- and trichloro-methylation of (iso)quinoline derivatives in batch and continuous flow” M. Therkelsen, M. T. Rasmussen, A. T. Lindhardt Chemical Communications 2015, 51, 9651–9654
“Continuous metal scavenging and coupling to one-pot copper-catalyzed azide-alkyne cycloaddition click reaction in flow” I.V. Gürsel, F. Aldiansyah, Q. Wang, T. Noël, V. Hessel Chemical Engineering Journal 2015, 270, 468–475
“Rapid and continuous oxidation of organic contaminants with ascorbic acid and a modified ferric/persulfate system” Y. Lei, H. Zhang, J. Wang, J. Ai Chemical Engineering Journal 2015, 270, 73–79
“Nafion-H-catalyzed high-temperature/high-pressure synthesis of a triarylmethane in continuous-flow mode” S. Hayden, T. Glasnov and C. O. Kappe Chemical Engineering & Technology 2015, DOI: 10._1002/ceat.201400581
“Highly selective continuous-flow synthesis of potentially bioactive deuterated chalcone derivatives” C. T. Hsieh, S. B. Ötvös, Y. C. Wu, I. M. Mandity, F. R. Chang, F. Fülöp ChemPlusChem 2015, 80, 859–864
“Flash chemistry using trichlorovinyllithium: Switching the reaction pathways by high-resolution reaction time control” A. Nagaki, Y. Takahashi, A. Henseler, C. Matsuo, J. Yoshida Chemistry Letters, 2015, 44, 214–216
“Gas-liquid segmented flow microwave-assisted synthesis of MOF-74(Ni) under moderate pressures” G. H. Albuquerque, R. C. Fitzmorris, M. Ahmadi, N. Wannenmacher, P. K. Thallapally, B. P. McGrail, G. S. Herman CrystEngComm 2015, 17, 5502–5510
“Enantioselective [small alpha]-amination of 1,3-dicarbonyl compounds in batch and flow with immobilized thiourea organocatalysts” P. Kasaplar, E. Ozkal, C. Rodriguez-Escrich, M. A. Pericas Green Chemistry 2015, 17, 3122–3129
“Catalyst coating on prefabricated capillary microchannels for the direct synthesis of hydrogen peroxide” V. Paunovic, V. Ordomsky, M. F. N. D’Angelo, J. C. Schouten, T. A. Nijhuis Industrial & Engineering Chemistry Research 2015, 54, 2919–2929
“Continuous photofermentative production of hydrogen by immobilized Rhodobacter sphaeroides O.U.001” R. Zagrodnik, K. Seifert, M. Stodolny, M. Laniecki International Journal of Hydrogen Energy 2015, 40, 5062–5073
“Sorption-enhanced reforming of bioethanol in dual fixed bed reactor for continuous hydrogen production” A. Lysikov, V. Derevschikov, A. Okunev International Journal of Hydrogen Energy 2015, DOI: 10._1016/j.ijhydene.2015._06._029
“Decarbonisation offossil energy via methane pyrolysis using two reactor concepts: Fluid wall flow reactor and molten metal capillary reactor” Schultz, D. W. Agar International Journal of Hydrogen Energy 2015, DOI: 10._1016/j.ijhydene.2015._03._126
“One-step, facile and ultrafast synthesis of phase- and size-controlled Pt-Bi intermetallic nanocatalysts through continuous-flow microfluidics” D. Zhang, F. Wu, M. Peng, X. Wang, D. Xia, G. Guo Journal of the American Chemical Society 2015, 137, 6263–6269
“Flow alkylation of thiols, phenols, and amines using a heterogenous base in a packed-bed reactor” A. Baker, M. Graz, R. Saunders, G. J. S. Evans, I. Pitotti, T. Wirth Journal of Flow Chemistry 2015, 5, 65–68
“The use of flow chemistry for two-phase dibromocyclopropanation of alkenes” R. B. Østby, Y. H. Stenstrom, T. Didriksen Journal of Flow Chemistry 2015, 5, 69–73
“Multistep continuous-flow synthesis of condensed benzothiazoles” K. Lövei, I. Greiner, J. Éles, A. Szigetvari, M. Dékany, S. Lévai, Z. Novak, G. I. Turós Journal of Flow Chemistry 2015, 5, 74–81
“Two-stage flow synthesis of coumarin via O-acetylation of salicylaldehyde” X. Li, A. Chen, Y. Zhou, L. Huang, Z. Fang, H. Gan, K. Guo Journal of Flow Chemistry 2015, 5, 82–86
“Influence of support properties on the activity of basic catalysts for aldol condensation of formaldehyde and methyl acetate in a continuous-flow reactor” Y. Wang, H. Chen, G. Zhao, M. Liu, X. Lang, Z. Zhu Journal of Flow Chemistry 2015, 5, 87–94
“Continuous-flow alcohol protection and deprotection reactions catalyzed by silica-supported sulfonic acid” S. A. van den Berg, R. A. M. Frijns, T. Wennekes, H. Zuilhof Journal of Flow Chemistry 2015, 5, 95–100
“Active mixing inside double emulsion segments in continuous flow” V. Misuk, A. Mai, Y. Zhao, J. Heinrich, D. Rauber, K. Giannopoulos, H. Löwe Journal of Flow Chemistry 2015, 5, 101–109
“Scaling up the throughput of synthesis and extraction in droplet microfluidic reactors” P. M. Korczyk, M. E. Dolega, S. Jakiela, P. Jankowski, S. Makulska, P. Garstecki Journal of Flow Chemistry 2015, 5, 110–118
“3D graphene/nylon rope as a skeleton for noble metal nanocatalysts for highly efficient heterogeneous continuous-flow reactions” S. Zhang, X. Shen, Z. Zheng, Y. Ma, Y. Qu Journal of Materials Chemistry A 2015, 3, 10504–10511
“Benzyllithiums bearing aldehyde carbonyl groups. A flash chemistry approach” A. Nagaki, Y. Tsuchihashi, S. Haraki, J. Yoshida J. Org. Biomol. Chem. 2015, 13, 7140–7145
“Multistep continuous-flow synthesis of (R)- and (S)-rolipram using heterogeneous catalysts” T. Tsubogo, H. Oyamada, S. Kobayashi Nature 2015, 520, 329–332
“Machines vs malaria: a flow-based preparation of the drug candidate OZ439” S-H. Lau, A. Galvan, R. R. Merchant, C. Battilocchio, J. A. Souto, M. B. Berry, S. V. Ley Organic Letters 2015, 17, 3218–3221
“Recovery of artemisinin from a complex reaction mixture using continuous chromatography and crystallization” Z. Horvath, E. Horosanskaia, J. W. Lee, H. Lorenz, K. Gilmore, P. H. Seeberger, A. Seidel-Morgenstern Organic Process Research & Development 2015, 19, 624–634
“Continuous-flow process for the synthesis of 2-ethylphenylhydrazine hydrochloride” Z. Yu, G. Tong, X. Xie, P. Zhou, Y. Lv, W. Su Organic Process Research & Development 2015, 19, 892–896
“Continuous-flow synthesis of meta-substituted phenol derivatives” J. H. Park, C. Y. Park, M. J. Kim, M. U. Kim, Y. J. Kim, G.-H. Kim, C. P. Park Organic Process Research & Development 2015, 19, 812–818
“The Biginelli reaction under batch and continuous flow conditions: catalysis, mechanism and antitumoral activity” G. C. O. Silva, J. R. Correa, M. O. Rodrigues, H. G. O. Alvim, B. C. Guido, C. C. Gatto, K. A. Wanderley, M. Fioramonte, F. C. Gozzo, R. O. M. A. de Souza, B. A. D. Neto RSC Advances 2015, 5, 48506–48515
“Continuous-flow hydrogenation of olefins and nitrobenzenes catalyzed by platinum nanoparticles dispersed in an amphiphilic polymer” T. Osako, K. Torii, A. Tazawa, Y. Uozumi RSC Advances 2015, 5, 45760–45766
“A continuous-flow synthesis of 1,4-benzodiazepin-5-ones, privileged scaffolds for drug discovery” M. Viviano, C. Milite, D. Rescigno, S. Castellano, G. Sbardella RSC Advances 2015, 5, 1268–1273 (also as Chemlnform 2015, 46 (20))
“A sequential Ugi multicomponent/Cu-catalyzed azide-alkyne cycloaddition approach for the continuous flow generation of cyclic peptoids” C. E. M. Salvador, B. Pieber, P. M. Neu, A. Torvisco, C. K. Z. Andrade, C. O. Kappe The Journal of Organic Chemistry 2015, 80, 4590–4602
“Polymerization of vinyl ethers initiated by dendritic cations using flow microreactors” A. Nagaki, M. Takumi, Y. Tani, J. Yoshida Tetrahedron 2015, 71, 5973–5978
Nanomaterials
“A versatile and robust microfluidic platform toward high throughput synthesis of homogeneous nanoparticles with tunable properties” D. Liu, S. Cito, Y. Zhang, C. Wang, T. M. Sikanen, H. A. Santos Advanced Materials 2015, 27, 2298–2304
“Microfluidic synthesis of biodegradable polyethylene-glycol microspheres for controlled delivery of proteins and DNA nanoparticles” L. Deveza, J. Ashoken, G. Castaneda, X. Tong, M. Keeney, L.-H. Han, F. Yang ACS Biomaterials Science & Engineering 2015, 1, 157–165
“Widening synthesis bottlenecks: realization of ultrafast and continuous-flow synthesis of high-silica zeolite SSZ-13 for NOx removal” Z. Liu, T. Wakihara, K. Oshima, D. Nishioka, Y. Hotta, S. P. Elangovan, Y. Yanaba, T. Yoshikawa, W. Chaikittisilp, T. Matsuo, T. Takewaki, T. Okubo Angewandte Chemie International Edition 2015, 54, 5683–5687
“Production of polymeric nanoparticles by micromixing in a co-flow microfluidic glass capillary device” R. Othman, G. T. Vladisavljevic, H. C. H. Bandulasena, Z. K. Nagy Chemical Engineering Journal 2015, 280, 316–329
“Process intensification: nano-carrier formation by a continuous dense gas process” C. C. Beh, R. Mammucari, N. R. Foster Chemical Engineering Journal 2015, 266, 320–328
“Scalable continuous solvo-jet process for ZIF-8 nanoparticles” H-S. Choi, S-J. Lee, Y-S. Bae, S-J. Choung, S-H. Im, J. Kim Chemical Engineering Journal 2015, 266, 56–63
“Continuous synthesis of hierarchical porous ZnO microspheres in supercritical methanol and their enhanced electrochemical performance in lithium ion batteries” J. Kim, S-A. Hong, J. Yoo Chemical Engineering Journal 2015, 266, 179–188
“Segmented flow-based multistep synthesis of cadmium selenide quantum dots with narrow particle size distribution” V. Misuk, M. Schmidt, S. Braukmann, K. Giannopoulos, D. Karl, H. Loewe Chemical Engineering & Technology 2015, 38, 1150–1153
“Segmented flow-based multistep synthesis of cadmium selenide quantum dots with narrow particle size distribution” V. Misuk, M. Schmidt, S. Braukmann, K. Giannopoulos, D. Karl, H. Loewe Chemical Engineering & Technology 2015, 38, 1150–1153
“Gas slug microfluidics: a unique tool for ultrafast, highly controlled growth of iron oxide nanostructures” A. Larrea, V. Sebastian, A. Ibarra, M. Arruebo, J. Santamaria Chemistry of Materials 2015, 27, 4254–4260
“Generation of alginate nanoparticles through microfluidics-aided polyelectrolyte complexation” K. Kim, D. Kang, M. Kim, K. Kim, K. Park, S. Hong, P. Chang, H. Jung Colloids and Surfaces A: Physicochemical and Engineering Aspects 2015, 471, 86–92
“The continuous synthesis and application of graphene supported palladium nanoparticles: a highly effective catalyst for Suzuki- Miyaura cross-coupling reactions” K. W. Brinkley, M. Burkholder, A. R. Siamaki, K. Belecki, B. F. Gupton Green Processing and Synthesis 2015, 4, 241–246
“Changing the size and surface roughness of polymer nanospheres formed using a microfluidic technique” I. Kucuk, M. Edirisinghe Journal of Minerals, Metals and Materials Society 2015, 67, 811–817
“Soft chemistry synthesis route toward Bi2Te3 hierarchical hollow spheres” J. Fouineau, J. Peron, S. Nowak, M. Giraud, M. Sicard, S. Ammar-Merah, L. Sicard Journal of Nanoparticle Research 2015, 17, 166
“The influence of stabilizers on the production of gold nanoparticles by direct current atmospheric pressure glow microdischarge generated in contact with liquid flowing cathode” A. Dzimitrowicz, P. Jamroz, K. Greda, P. Nowak, M. Nyk, P. Pohl Journal of Nanoparticle Research 2015, 17, 185
“On-demand one-step synthesis of monodisperse functional polymeric microspheres with droplet microfluidics” X. Yu, G. Cheng, M. Zhou, S. Zheng Langmuir 2015, 31, 3982–3992
“Role of self-polarization in a single-step controlled synthesis of linear and branched polymer nanoparticles” N. Visaveliya, J. M. Koehler Macromolecular Chemistry and Physics 2015, 216, 1212–1219
“Controlled synthesis of layered double hydroxide nanoplates driven by screw dislocations” A. Forticaux, L. Dang, H. Liang, S. Jin Nano Letters 2015, 15, 3403–3409
“Continuous preparation of Fe3O4 nanoparticles using a rotating packed bed: dependence of size and magnetic property on temperature” C. Lin, J. Ho, M. Wu, Powder Technology 2015, 274, 441–445
“One-step, facile and ultrafast synthesis of phase- and size-controlled Pt-Bi intermetallic nanocatalysts through continuous-flow microfluidics” D. Zhang, F. Wu, M. Peng, X. Wang, D. Xia, G. Guo Journal of the American Chemical Society 2015, 137, 6263–6269
“Semi-automated nanoprecipitation-system-an option for operator independent, scalable and size adjustable nanoparticle synthesis” R. Rietscher, C. Thum, C. Lehr, M. Schneider Pharmaceutical Research 2015, 32, 1859–1863
Reviews
“Liquid phase oxidation chemistry in continuous-flow microreactors” H. P. L. Gemoets, Y. Su, M. Shang, V. Hessel, R. Luque, T. Noel Chemical Society Reviews 2015, DOI: 10._1039/C5CS00447K
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Kulkarni, A.A. Highlights from the Flow Chemistry Literature 2015 (Part 2). J Flow Chem 5, 190–194 (2015). https://doi.org/10.1556/1846.2015.00032
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DOI: https://doi.org/10.1556/1846.2015.00032