Abstract
We studied the effect of carbon ions (12C) with an energy of 500 MeV/nucleon at a dose of 1 Gy on monoamine metabolism in the brains of rats of different ages. Neurochemical parameters that characterize the distribution of noradrenaline (NA), dopamine (DA), serotonin (5-HT), and its metabolites were evaluated during 2 months on days 30 and 90 after the exposure to radiation. We studied the prefrontal cortex, hypothalamus, hippocampus, and striatum. The results showed changes in the activities of the NA, DA, and 5-HT systems in rats of different age groups after exposure to radiation. The most prominent differences in the exposed and control animals were observed in the prefrontal cortex and hypothalamus, which indicates the important role of these brain regions in long-term effects of exposure to radiation on the central nervous system. A comparison of animals from different age groups showed a decrease in the intensity of the temporal changes in all analyzed structures except the striatum in the exposed rats. Based on these findings, we assumed that the activation of compensatory and repairing mechanisms occurs in the late post-radiation period. At relatively low linear energy transfer of particles (10.6 keV/µm), it may lead to the partial recovery of brain functions that were impaired by radiation. At higher values of the linear energy transfer, the compensatory and recovery processes are activated to a lesser degree and functional impairment increases with time.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Parihar, V.K., Allen, B., Tran, K.K., Macaraeg, T.G., Chu, E.M., Kwok, S.F., Chmielewski, N.N., Craver, B.M., Baulch, J.E., Acharya, M.M., Cucinotta, F.A., and Limoli, C.L., Sci. Adv., 2015, vol. 1, no. 4, pp. 1–6.
Grigor’ev, A.I., Krasavin, E.A., and Ostrovskii, M.A., Ros. Fiziol. Zhurn. im. I.M. Sechenova, 2013, vol. 99, no. 3, pp. 273–280.
Cucinotta, F.A., Alp, M., Sulzman, F.M., and Wang, M., Life Sci. Space Res., 2014, vol. 2, pp. 54–69.
Kalmykov, N.I., Kulikov, G.V., and Roganova, T.M., Model’ kosmosa. T. 1. Fizicheskie usloviya v kosmicheskom prostranstve, (Model of the Space, vol. 1. Physical Conditions in the Space), Panasyuk, M.I., Ed., Moscow: KDU, 2007, pp. 62–96.
Dorman, L.M., Eksperimental’nye i teoreticheskie osnovy astrofiziki kosmicheskikh luchei (Experimental and Theoretical Basics of Astrophysics of the Cosmic Rays), Moscow: Nauka, 1975.
Matveeva, M.I., Shtemberg, A.S., Timoshenko, G.N., Krasavin, E.A., Narkevich, V.B., Klodt, P.M., Kudrin, V.S., and Bazyan, A.S., Neurochem. J., 2013, vol. 7, no. 4, pp. 303–307.
Shtemberg, A.S., Kokhan, V.S., Kudrin, V.S., Matveeva, M.I., Lebedeva-Georgievskaya, K.D., Timoshenko, G.N., Molokanov, A.G., Krasavin, E.A., Narkevich, V.B., Klodt, P.M., and Bazyan, A.S., Neirokhimiya, 2015, vol. 9, no. 1, pp. 66–72.
Bazyan, A.S., Grigor’yan, G.A., and Ioffe, M.E., Usp. Fiziol. Nauk, 2011, vol. 42, no. 3, pp. 65–80.
Bazyan, A.S., Usp. Fiziol. Nauk, 2013, vol. 44, no. 4, pp. 3–23.
Bazyan, A.S. and Rogal’, A.V., Usp. Fiziol. Nauk, 2015, vol. 46, no. 1, pp. 3–21.
Belokopytova, K.V., Belov, O.V., Kudrin, V.S., Narkevich, V.B., Klodt, P.M., Bazyan, A.S., Krasavin, E.A., and Timoshenko, G.N., Neirochem. J., 2015, vol. 9, no. 3, pp. 214–220.
Segovia, G., Porras, A., Del Arco, A., and Mora, F., Mech. Ageing Dev., 2001, vol. 122, pp. 1–29.
Koprowska, M., Krotewicz, M., Romaniuk, A., and Strzelczuk, M., Acta Neurobiol. Exp. (Wars.), 2004, vol. 64, pp. 131–142.
Morgan, D.G. and May, P.C., Handbook of the Biology of Aging, Schneider, E.L. and Rowe, J.W.N.Y, Eds., New-York: Acad. Press, 1990.
McEntee, W.J. and Crook, T.H., Psychopharmacol., 1991, vol. 103, pp. 143–149.
Fisher, W., Chen, K.S., Gage, F.H., and Bjorklund, A., Neurobiol. Aging, 1992, vol. 13, pp. 9–23.
Finch, C.E. and Roth, G.S., in Basic Neurochemistry, Molecular, Cellular and Medical Aspects, Siegel, G.J., Agranoff, B.W., Albers, R.W., Fisher, S.K., and Uhler, M.D., Eds., Philadelphia: Lippincott-Raven Publishers, 1999, pp. 613–633.
Demarest, K.T., Riegle, G.D., and Moore, K.E., Neuroendocrin., 1980, vol. 31, pp. 222–227.
Carfagna, N., Trunzo, F., and Moretti, A., Exp. Gerontol., 1985, vol. 20, pp. 265–269.
Moretti, A., Carfagna, N., and Trunzo, F., Neurochem. Res., 1987, vol. 12, pp. 1035–1039.
Venero, J.L., Machado, A., and Cano, J., J. Neurochem., 1991, vol. 56, pp. 1940–1948.
Finch, C.E., Brain. Res., 1976, vol. 52, pp. 261–276.
Ponzio, F., Brunello, N., and Algeri, S., J. Neurochem., 1978, vol. 30, pp. 1617–1620.
Brizee, K.R., Samorajski, T., Smith, R.C., and Brizee, D.L., Brain Neurotransmitters and Receptors in Aging and Age-related Disorders (Aging. vol. 17), Enna, S.J., Samorajski, T., and Beer, B., Eds., New York: Raven Press, 1998, pp. 59–80.
Gerhardt, G.A., Cass, W.A., Yi, A., Zhang, Z., and Gash, D.M., J. Neurochem., 2002, vol. 80, pp. 168–177.
Siddigi, Z., Kemper, T.I., and Kiliany, R., J. Neuropathol. Exp. Neurol., 1999, vol. 58, pp. 959–971.
Estes, K.S. and Simpkins, J.W., Brain. Res., 1980, vol. 194, pp. 556–560.
Algeri, S., Calderini, G., Tofano, G., and Ponzio, F., Aging of the Brain (Aging. vol. 22), Samuel, D., Algeri, S., Gershon, S., Grimm, V.E., and Toffano, G., Eds., New York: Raven Press, 1983, pp. 227–243.
Santiago, M., Machado, A., Reinoso-Suárez, F., and Cano, J., Life Sci., 1988, vol. 42, pp. 2503–2508.
David, J.C., Coulon, J.F., Cavoy, A., and Delacour, J., J. Neurochem., 1989, vol. 53, pp. 149–154.
Venero, J.L., De la Roza, C., Machado, A., and Cano, J., Brain Res., 1993, vol. 631, pp. 89–96.
Ponzio, F., Calderini, G., Lomuscio, G., Vantini, G., Toffano, G., and Algeri, S., Neurobiol. Aging, 1982, vol. 3, pp. 23–29.
Harik, S.I. and McCracken, K.A., Brain Res., 1986, vol. 381, pp. 125–130.
Machado, A., Cano, J., and Santiago, M., Arch. Gerontol. Geriatr., 1986, vol. 5, pp. 333–342.
Strong, R., Samorajski, T., and Gottesfeld, Z., J. Neurochem., 1984, vol. 43, pp. 1766–1768.
Meek, J.L., Bertilsson, L., Cheney, D.L., Zsilla, G., and Costa, E., J. Gerontol., 1977, vol. 32, pp. 129–131.
Roubein, Y.F., Embree, L.J., and Jackson, D.W., Exp. Aging Res., 1986, vol. 12, pp. 193–196.
Simpkins, J.W., Mueller, G.P., Huang, H.H., and Meites, J., Endocrinol., 1977, vol. 100, pp. 1672–1678.
Brunello, N., Riva, M., Rovescalli, A.C., Galimberti, R., and Racagni, G., Pharmacol. Toxicol., 1988, vol. 63, pp. 150–155.
Pradhan, S.N., Life Sci., 1980, vol. 26, pp. 1643–1656.
Allen, S.J., Benton, J.S., Goodhardt, M.J., Haan, E.A., Sims, N.R., Smith, C.C., Spillane, J.A., Bowen, D.M., and Davison, A.N., J. Neurochem., 1983, vol. 41, pp. 256–265.
Grachev, I.D. and Apkarian, A.V., Cogn. Brain Res., 2001, vol. 11, pp. 185–197.
Hare, T.A., Wood, J.H., Manyam, B.V., Gerner, R.H., Ballenger, J.C., and Post, R.M., Arch. Neurol., 1982, vol. 39, pp. 247–249.
Bazyan, A.S., Neirokhimiya, 1999, vol. 16, no. 2, pp. 88–103.
Bazyan, A.S., Usp. Fiziol. Nauk, 2001, vol. 32, no. 3, pp. 3–22.
Bazyan, A.S. and Segal, O.L., Neurochem. J., 2009, vol. 3, no. 2, pp. 77–86.
Bazyan, A.S., Orlova, N.V., and Getsova, V.M., Zh. Vyssh. Nervn. Deyat. im. I.P. Pavlova, 2000, vol. 50, no. 3, pp. 500–508.
Bazyan, A.S. and Grigor’yan, G.A., Usp. Fiziol. Nauk, 2006, vol. 37, no. 1, pp. 68–83.
Migues, J.M., Aldegunde, M., Paz-Valinas, L., Recio, J., and Sanchez-Barcelo, E., J. Neural Transm., 1999, vol. 106, pp. 1089–1098.
Galva, M.D., Bondiolotti, G.P., Olasmaa, M., and Picotti, G.B., J. Neural Transm. [Gen. Sect.], 1995, vol. 101, pp. 83–94.
Darbin, O., Risso, J.-J., and Rostain, J.-C., Neurosci. Let., 1997, vol. 238, pp. 69–72.
Britten, R.A., Davis, L.K., Johnson, A.M., Keeney, S., Siegel, A., Sanford, L.D., Singletary, S.J., and Lonart, G., Radiat. Res., 2012, vol. 177, pp. 146–151.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © K.V. Belokopytova, O.V. Belov, V.S. Kudrin, V.B. Narkevich, E.A. Krasavin, G.N. Timoshenko, A.S. Bazyan, 2016, published in Neirokhimiya, 2016, Vol. 33, No. 2, pp. 147–155.
Rights and permissions
About this article
Cite this article
Belokopytova, K.V., Belov, O.V., Kudrin, V.S. et al. The dynamics of monoamine metabolism in rat brain structures in the late period after exposure to accelerated carbon ions. Neurochem. J. 10, 137–143 (2016). https://doi.org/10.1134/S1819712416020021
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1819712416020021