Abstract
Model experiments using monkeys (rhesus macaque monkeys) were performed to investigate the neurobiological effects of two components of galactic cosmic radiation, namely, high-energy protons and carbon (12C) ions. It has been demonstrated that the irradiation of a monkey’s head with protons at a dose of 3 Gy did not cause any significant changes in the animal’s cognitive function and in the concentrations of monoamines and their metabolites in the peripheral blood. However, exposure to carbon ions at a dose of 1 Gy resulted in a significant cognitive function impairment and a significant decrease in serotonin metabolite concentrations in the blood in the monkeys with the excitable imbalanced type of higher nervous activity.
Article PDF
Similar content being viewed by others
Explore related subjects
Discover the latest articles, news and stories from top researchers in related subjects.Avoid common mistakes on your manuscript.
References
Vasil’eva, O.N., Kapustina, E.A., and Korol’kov, V.I., Kosm. Biol. Aviakosm. Med., 2003, vol. 37, no. 6, pp. 55–63.
Washburn, D.A., Rumbaugh, D.M., Richardson, W.K., Gulledge, J.P., Shlyk, G.G., and Vasilieva, O.N., J. Gravit. Physiol., 2000, vol. 7, no. 1, pp. 89–93.
Matveeva, M.I., Shtemberg, A.S., Timoshenko, G.N., Krasavin, E.A., Narkevich, V.B., Klodt, P.M., Kudrin, V.S., and Bazyan, A.S., Neirokhimiya, 2013, vol. 30, no. 4, pp. 343–348.
Belokopytova, K.V., Belov, O.V., Kudrin, V.S., Narkevich, V.B., Klodt, P.M., Bazyan, A.S., Krasavin, E.A., and Timoshenko, G.N., Neirokhimiya, 2015, vol. 32, no. 3, pp. 243–251.
Lebedinskii, A.V. and Nakhil’nitskaya, Z.N., Vliyanie ioniziruyushchikh izluchenii na nervnuyu sistemu (Effects of Ionizing Radiation on Nervous System), Moscow: Atomizdat. 1960.
Livshits, N.N., Vliyanie ioniziruyushchikh izluchenii na funktsii tsentral’noi nervnoi sistemy (Effects of Ionizing Radiation on Central Nervous System Functions), Moscow: Akad. Nauk SSSR, 1961.
Livanov, M.N., Nekotorye problemy deistviya ioniziruyushchei radiatsii na nervnuyu sistemu (Some Questions on the Ionizing Radiation Impact on Central Nervous System), Moscow: Medgiz, 1962.
Minaev, P.F., Vliyanie ioniziruyushchikh izluchenii na tsentral’nuyu nervnuyu sistemu (Effects of Ionizing Radiation on Central Nervous System), Moscow: Acad. Nauk SSSR, 1962.
Shtemberg, A.S., Izv. Akad. Nauk SSSR, Ser. Biol., 1987, no. 4, pp. 547–557.
Bol’shev, L.N. and Smirnov, N.V., Tablitsy matematicheskoi statistiki (Mathematical Statistics Tables), Moscow: Nauka, 1983.
Blair, W.C., J. Compar. and Physiol. Psychol., 1958, vol. 54, no. 2, pp. 175–178.
Harlow, H.F., Scrier, A.M., and Simons, D.G., J. Compar. and Physiol. Psychol., 1956, vol. 49, no. 2, pp. 195–200.
Riopelle, A.J., Gronsky, M.A., and Ades, H.W., J. Compar. and Physiol. Psychol., 1956, vol. 49, no. 5, pp. 521–524.
Rabin, B.M., Joseph, J.A., and Shukitt-Hale, B., Adv. Space Res., 2004, vol. 33, no. 8, pp. 1330–1333.
Rabin, B.M., Joseph, J.A., and Shukitt-Hale, B., Radiat. Res., 2005, vol. 164, no. 4, pt. 2, pp. 552–555.
Machida, M., Lonart, G., and Britten, R.A., Radiat. Res., 2010, vol. 174, no. 5, pp. 618–623.
Britten, R.A., Davis, L.K., Johnson, A.M., Keeney, S., Siegel, A., Sanford, L.D., Singletary, S.J., and Lonart, G., Radiat. Res., 2012, vol. 177, no. 2, pp. 146–151.
Shukitt-Hale, B., Casadesus, G., McEwen, J.J., Rabin, B.M., and Joseph, J.A., Radiat. Res., 2000, vol. 154, no. 1, pp. 28–33.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © A.G. Belyaeva, A.S. Shtemberg, A.M. Nosovskii, O.N. Vasil’eva, Yu.V. Gordeev, V.S. Kudrin, V.B. Narkevich, E.A. Krasavin, G.N. Timoshenko, B.A. Lapin, A.S. Bazyan, 2017, published in Neirokhimiya, 2017, Vol. 34, No. 2, pp. 168–176.
Rights and permissions
About this article
Cite this article
Belyaeva, A.G., Shtemberg, A.S., Nosovskii, A.M. et al. The effects of high-energy protons and carbon ions (12C) on the cognitive function and the content of monoamines and their metabolites in peripheral blood in monkeys. Neurochem. J. 11, 168–175 (2017). https://doi.org/10.1134/S1819712417010032
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1819712417010032