Abstract
The influence of N-acetylcysteine (ACC) on the cytogenetic effects of etoposide in F1 CBA × C57BL/6 mice was studied. Etoposide introduced intraperitoneally in doses of 10, 20, 40, and 60 mg/kg has a dose-dependent clastogenic activity and has an aneugenic effect with the induction of mainly hypohaploid oocytes. ACC significantly decreases the aneugenic and clastogenic activity of etoposide (20 mg/kg) in oocytes of 6-, 9-, and 12-week-old mice during triple introduction at a dose 200 mg/kg per os. The most pronounced anticlastogenic ACC activity (an 80% decrease) was registered in 9-week-old females; a 100% decrease in aneugenesis was detected in 6-week-old female mice.
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Original Russian Text © K.L. Pligina, A.K. Zhanataev, A.V. Kulakova, Z.V. Chaika, A.D. Durnev, 2016, published in Genetika, 2016, Vol. 52, No. 2, pp. 215–220.
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Pligina, K.L., Zhanataev, A.K., Kulakova, A.V. et al. Influence of acetylcysteine on cytogenetic effects of etoposide in mouse oocytes. Russ J Genet 52, 188–193 (2016). https://doi.org/10.1134/S1022795415110125
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DOI: https://doi.org/10.1134/S1022795415110125