Abstract
Metastatic hydatid disease of the lung may happen when a hydatid cyst (HC) anywhere in the body ruptures into a systemic vein, a right heart chamber or a pulmonary artery (PA), resulting in the embolisation of the cyst’s contents into the lungs. We submit herewith, the images of embolised hydatids within the PA, in a patient who had surgery for HC involving the right ventricular (RV) wall in 2014. Despite adequate surgical and medical management, investigations in 2017 revealed multiple embolised cysts within PA branches. Further continued medical therapy resulted only in partial resolution of the disease, indicating probably the inadequacy of the currently available treatment strategies.
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The lung is the second most commonly affected organ in the zoonosis caused by the cestode echinococcus. In humans, pulmonary hydatids manifest themselves as cysts, when the oncospheres hatching out of ingested eggs in the bowel find their way into the lungs. Rarely, these eggs may be inhaled. The lungs may also get secondarily infested when a cyst in an adjacent organ erodes into it, or when a pulmonary cyst ruptures into a bronchus [1]. Besides these usual ways of lung involvement, metastatic infestation of the lung may also happen when a hydatid cyst (HC) anywhere in the body ruptures into a systemic vein, right heart chambers or a pulmonary artery (PA), embolising the lungs with its contents—the scolices and the daughter cysts [1]. This embolisation may happen spontaneously, or as a complication of trauma or surgery on a hydatid.
A 22-year-old man was diagnosed in 2014 to have a right ventricular (RV) wall hydatid and an emptied left upper lobe of lung (LUL) hydatid, when he presented with complaints of chest pain, breathlessness, cough, salty expectorations and syncope (Figs. 1 and 2a). He had a history of sternal compressions initiated on him during an episode of syncope, by a bystander. When the cardiac cyst was excised, some punctate openings in the base of the pericyst were also closed meticulously [2]. The RV lumen was not opened. Perioperatively, he was treated with four interrupted cycles of albendazole and praziquantel over 6 months. His follow-up investigations over the next two years were normal. In 2017, he complained of mild breathlessness, and investigations revealed metastatic hydatids within some segmental PA, and a recurrence in the LUL (Figs. 2b and 3). The D-dimer levels were normal. Echocardiogram showed no cardiac lesions or evidence of pulmonary hypertension. Imaging in 2018 showed infarction of a portion of the left lower lobe of lung (LLL), corresponding to the emboli (Figs. 2c and 4). In 2019, the x-ray showed resolution of the LLL lesion only (Fig. 2d). From 2017 till date, he has been on repeated cycles of both drugs. His liver function tests and blood cell counts have always been normal.
Cardiac hydatidosis is known to cause syncope, besides other symptoms [3]. The trauma caused by the sternal compressions, the surgery or the disease process by itself may have resulted in the embolisation. Another possible cause is the LUL cyst rupturing into an adjacent PA branch. However, pulmonary hydatids are more likely to rupture into a bronchus or the pleural cavity, than into a PA [1]. These emboli may produce the conventional signs and symptoms of pulmonary embolism [4, 5]. Surgery, complemented by chemotherapy, is the recommended treatment for pulmonary hydatids [6,7,8]. Patients unfit for surgery, complex diseases, recurrences and embolisation are best treated medically [4, 9]. Enucleation or embolectomy may be considered to treat the emboli, but could lead to major complications [4, 5]. Opinions differ regarding the appropriate drug regimen and follow-up strategies. There are many reports of partial responses and recurrences with the currently available treatment protocols [6,7,8,9,10,11,12].
We wish to publish these images highlighting this uncommon complication of hydatidosis and stress upon the need for further research into this orphaned disease.
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All authors contributed to the study conception and design, material preparation discussions and image selection. The drafts and the final manuscript were written by Prof. Birla Roy Gnanamuthu and all authors read and approved the final manuscript.
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Mohammad, A., Sameer, M., Vimala, L.R. et al. Pulmonary embolism from cardiac hydatids. Indian J Thorac Cardiovasc Surg 37, 205–208 (2021). https://doi.org/10.1007/s12055-020-01070-4
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DOI: https://doi.org/10.1007/s12055-020-01070-4