Abstract
The risk factors, especially laboratory indicators, of prognosis after acute kidney injury (AKI) remain unclear. We conducted a retrospective survey of Chinese People’s Liberation Army General Hospital from January 1, 2012 to December 31, 2012 according to the AKI diagnosis standard issued by Kidney Disease Improving Global Outcomes. The epidemiological features and factors influencing hospital mortality and renal function recovery were evaluated through logistic regression analysis. Among 77 662 cases of hospitalized patients, 1387 suffered from AKI. The incidence rate and mortality of AKI were 1.79% and 14.56%, respectively. Multivariate logistic regression analysis revealed that high AKI stage, age greater than 80 years, neoplastic disease, low cardiac output, increased white blood cell count, and decreased platelet count and serum albumin levels were the risk factors affecting the mortality of AKI patients. Conversely, body mass index between 28 and 34.9 was a protective factor. Increased AKI stage, tumor disease, post-cardiopulmonary resuscitation, and RRT were the risk factors of renal function recovery upon discharge. In addition to traditional risk factors, white blood cell count, platelet count, albumin, and BMI were the predictors of the mortality of AKI patients. No laboratory indicators were found to be the risk factors of renal function recovery in AKI patients.
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Acknowledgments
This study was supported by the National Key Technology R&D Program (Nos. 2013BAI09B05 and 2015BAI12B06), the Beijing Municipal Science and Technology Commission (No. Z131107002213011), the Special Fund for NHFPC Scientific Research in the Public Welfare (No. 201502023), and the Fund of Chinese PLA 12th Five-Year Plan for Medical Sciences (Nos. BWS14J040 and BWS11J027).
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Nie, S., Feng, Z., Xia, L. et al. Risk factors of prognosis after acute kidney injury in hospitalized patients. Front. Med. 11, 393–402 (2017). https://doi.org/10.1007/s11684-017-0532-9
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DOI: https://doi.org/10.1007/s11684-017-0532-9