Abstract
Coffee is one of the most consumed products globally, and its contamination with potentially toxic elements (PTEs) occurs throughout the production chain and production. Therefore, the current meta-analysis study aimed to estimate the concentration of essential elements (Cu and Co) and the contamination of PTEs (Ni, Cr, Pb, As, and Cd) in coffee. The recommended databases, including PubMed, Scopus, and ScienceDirect, were investigated to collect data regarding the contamination of PTEs in coffee products from 2010 to 2021. Among 644 retrieved citations in the identification step, 34 articles were included in the meta-analysis. The pooled mean concentration of essential elements in coffee products is much higher than that of toxic elements (Co (447.106 µg/kg, 95% CI: 445.695–448.518 µg/kg) > Ni (324.175 µg/kg, 95% CI: 322.072–326.278 µg/kg) > Cu (136.171 µg/kg, 95% CI: 134.840–137.503 µg/kg) > Cr (106.865 µg/kg, 95% CI: 105.309–108.421 µg/kg) > Pb (21.027 µg/kg, 95% CI: 20.824–21.231 µg/kg) > As (3.158 µg/kg, 95% CI: 3.097–3.219 µg/kg) > Cd (0.308 µg/kg; 95% CI: 0.284–0.332 µg/kg)). Results showed high differences between pooled concentrations of all PTEs in coffee products of different countries.
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Introduction
Chemical pollution of the environment (Guan et al. 2021; Li et al. 2021; Lin et al. 2021; Liu et al. 2011, 2020; Quan et al. 2021; Shi et al. 2021) followed by food contamination (Liu et al. 2022; Sun et al. 2022; Wang et al. 2022) has become a global concern. Coffee is an attractive beverage worldwide because of its pleasant aroma and taste. Coffee consumption varies according to geographical location (Godos et al. 2014). Flanders in Northern Europe and Bosnia and Herzegovina in Southern Europe are the largest consumers of coffee. The World Coffee Organization states that 500 billion cups of coffee are consumed annually (Dieng et al. 2017). Coffee and tea have been consumed for hundreds of years and have become an important part of cultural traditions and social life. In addition, people use coffee drinks to increase alertness and work productivity (Samet et al. 2018). The highest caffeine consumption in a typical meal is coffee, energy drinks, and caffeinated pills. The intermediate level is tea, and the lowest amount of soda (Rattan et al. 2015; van Dam et al. 2020). Caffeine is an alkaloid belonging to methylxanthine. It is also a chemical stimulant found naturally (Wolde 2014). Studies showed that coffee consumption has chronic and acute effects on human health (Nędzarek et al. 2013). Caffeine can act as an antioxidant to prevent diseases. Caffeine also can reduce the risk of several chronic diseases such as liver cancer, diabetes, coronary heart disease, osteoporosis, and gastritis (Nartea et al. 2022). Moreover, the absorption of many vital nutrients such as vitamin B6 is reduced by caffeine intake and the absorption of essential minerals such as magnesium (Mg), iron (Fe), and calcium (Ca) (de Mejia and Ramirez-Mares 2014; Escott-Stump 2008; Wolde 2014). However, consuming large amounts of this drink is not recommended because of some contaminants, including mycotoxins and potentially toxic elements (PTEs), besides to adverse effects of caffeine (Barrea et al. 2021; Batrinou et al. 2020; Berman et al. 2022; Khaneghah et al. 2019; Nourbakhsh and Tajbakhsh 2021; Pavithra 2021; Yazdanpanah et al. 2022).
It needs about 20 essential elements for the proper functioning of the human body. The list of metallic elements that are essential for the human body include sodium (Na), potassium (K), Mg, Ca, manganese (Mn), Fe, cobalt (Co), copper (Cu), zinc (Zn), molybdenum (Mo), and elements like tin (Sn), nickel (Ni), and vanadium (V), and are assumed not to be necessary for humans, according to chromium (Cr); based on experimental animal results, these metals were considered essential for the human body in the past (Zoroddu et al. 2019). Cu and Co are essential elements in the human body, a small amount of which plays a vital role in the body. The amount of Co we need is minimal, and only about 2 mg of it is needed for humans. High levels of Cu can cause cardiovascular disease such as cardiac arrhythmias. In addition, high levels of Cu lead to dementia, lung cancer, and lymphoma (Bost et al. 2016). The presence of Cu in the body interferes with the nervous system and causes Wilson’s disease, and also, the presence of Cu in the brain leads to brain damage (Kalita et al. 2019).
PTEs are a serious and worrying environmental problem (Bounar et al. 2020; Gao et al. 2022; Mirmahdi et al. 2022). They are widely distributed in the environment and thus intake by humans through water, air, soil, and even the food chain (Alkherraz et al. 2019; Heshmati et al. 2020). Accumulating PTEs in the body has negatively affected human health (Fu and Xi 2020; Mirmahdi et al. 2021). These effects include interfering with the immune and nervous systems, endocrine disorders, and malformations (Khaneghah et al. 2020). Organic compounds of lead (Pb) can be absorbed through the skin and enter the brain, causing toxins in the central nervous system. Pb also causes oxidative stress and causes cells to lose antioxidants (Fu and Xi 2020). Adverse effects of Pb include chromosome aberrations, mutations, DNA breakdown, and inhibition of DNA synthesis (Ibrahem et al. 2020). Cadmium (Cd) is a toxic and dangerous metal. The World Health Organization limited the tolerable weekly Cd exposure to 50 µg and recommended it as 0.007 mg/kg body weight (World Health Organization 2000). Depending on the route of exposure and duration, Cd can cause damage to the lung, liver, kidney, bone, testicle, and placenta (Hocaoğlu-Özyiğit and Genç 2020). Arsenic (As) is another PTE that causes damage and changes in DNA synthesis and cancer, cardiovascular and lung diseases, reproductive outcomes, and cognitive impairment in adults and children (Hu et al. 2022). Studies show that chronic exposure to As causes lung cancer, breast cancer, and bladder, kidney, and larynx diseases. It causes respiratory problems, infertility in adults, and premature birth in infants (Delgado Quezada et al. 2020; Khan et al. 2020; Pullella and Kotsopoulos 2020). Cr has a different effect on human health depending on the target dose and organ. Effects include respiratory problems, asthma, lung cancer, skin diseases such as dry skin, allergies, dizziness, general weakness, eye irritation, kidney stones, liver problems, gastrointestinal disorders, heart problems, blood disorders, reproduction problems, growth problems, nostril problems, and corneal damage (Ameri et al. 2021). Dental malformations such as discoloration and erosion are accompanied by high concentrations of Cr in the tongue papilla (Achmad and Auerkari 2017; Martineli et al. 2022; Teklay 2016). Ni is an element that may be widely derived from natural resources and human activities in the environment, air, water, and soil. Ni exposure causes digestive diseases, lung problems, lung cancer, and cardiovascular disease (Genchi et al. 2020).
This study systematically reviewed the prevalence of essential elements (Cu and Co) and potentially toxic elements (As, Cr, Cd, Pb, and Ni) in coffee products. Also, another goal of this study was to meta-analyze the results and identified the elements and geographical areas with the highest prevalence.
Material and method
Searching strategy
According to PRISMA guidelines, our study conducted the search strategy (Fig. 1) (Moher et al. 2010). International databases, including Scopus and PubMed (January 2000 and 20 June 2021), were screened to get papers on PTE concentrations in coffee products. Keywords referred to in the title and abstract of citations were [“heavy metal” OR “potentially toxic elements” OR “toxic elements” OR “elements” OR “toxic metal”] AND [“coffee products” OR “coffee” OR “caffeine” OR “cappuccino” OR “espresso”]. The reference list of papers was assessed for possible papers missed in the title and abstract screening step.
Inclusion and exclusion criteria and extraction of data
Our criteria included the following: detection of PTE concentrations in coffee products, full text available, contamination or prevalence investigation, no language limitation, no restriction for the study location, and present of mean, standard deviation, and/or range concentration of PTEs. One study was excluded because it did not meet the above criteria. One of the authors extracted the data in the retrieved paper. Data extracted from each article included the country, sample size, the mean and standard deviation of concentration, and measurement method.
Meta-analysis of data
The concentration of PTEs in coffee products was meta-analyzed based on the standard error (SE) of the equation:
where SD is the standard deviation and n is the number of samples when the I2 index is higher than 50% and heterogeneity is considerable (Higgins et al. 2008; Higgins and Thompson 2002; Quan and Zhang 2003); hence, the random-effect model was used for the meta-analysis of the concentration of PTEs in coffee products. PTE concentration’s mean and standard deviation were converted to µg/kg. A data meta-analysis was performed using Stata, version 14 (Stata Corporation, College Station, TX).
Result and discussion
Our study included thirty-four papers with 151 data reports (Fig. 1). The overall rank order of PTEs in the coffee products was as follows: Co (447.106 µg/kg, 95% CI: 445.695–448.518 µg/kg) > Ni (324.175 µg/kg, 95% CI: 322.072–326.278 µg/kg) > Cu (136.171 µg/kg, 95% CI: 134.840–137.503 µg/kg) > Cr (106.865 µg/kg, 95% CI: 105.309–108.421 µg/kg) > Pb (21.027 µg/kg, 95% CI: 20.824–21.231 µg/kg) > As (3.158 µg/kg, 95% CI: 3.097–3.219 µg/kg) > Cd (0.308 µg/kg; 95% CI: 0.284–0.332 µg/kg). As it is obvious from this part of the result, the pooled mean concentration of essential elements in coffee products is much higher than that of toxic elements. Thus, the distribution of PTEs in coffee products is uneven because their content depends on numerous factors (Bost et al. 2016).
It should bear in mind that coffee plants need essential elements (like Co, Ni, and Cu) for their development, so they absorb them from water and soil selectively during growth which is influenced by the soil characteristics (chemical composition) in addition to the overall environmental growth conditions (climate, temperature, and agricultural practices) (Barbosa et al. 2014; Habte et al. 2016; Pigozzi et al. 2018). Petrović et al. (2020) also reported that the accumulation of PTEs in plants relates to the plant’s affinity to take up the appropriate element. Furthermore, there is usually a higher concentration of essential elements in the soil than toxic elements since they exist naturally in the rocks and release into water and soil through rock weathering and human activities (like mining) (Atamaleki et al. 2020; Pigozzi et al. 2018). Higher Co, Ni, and Cu pooled concentrations in the coffee products could also be attributed to the greater availability of these PTEs in the soils used for coffee plantation. Therefore, due to the active transmission of essential elements through the soil-root interface and their high content in the soil used for coffee cultivation, they might be readily absorbed by the plant and accumulated in the coffee beans compared with other PTEs (da Silva et al. 2017). As also evident in a study of da Silva et al. (2017), the elements of Cu, Ni, and Zn are necessary to the growth of the coffee plant, being utilized in the soil or coffee leaf, and are subsequently present in the coffee beans. Furthermore, some PTEs like Cu exist in pesticide ingredients applied in cultivation which assists the uptake of these PTEs by plants, validating its presence in coffee beans (da Silva et al. 2017). Albals et al. (2021) also noted that Co and Cu mainly exist at high concentrations in most plants when cultivated in contaminated soil. Cd is found at lower concentrations in such products than in fish.
PTE contamination in coffee products also has diverse forms associated with size, charge, hydrophobicity, activity, bioaccessibility, coffee variety, and type of processing (Alkherraz et al. 2019; Pohl et al. 2014; Şemen et al. 2017). The concentration of PTEs in coffee is also related to its processing, especially the roasting of coffee beans and coffee beverages’ preparation method (Tiep 2014). When it comes to coffee infusions, several researchers reported that the releasing amount of different PTEs to coffee infusions from the solid sample is different based on coffee type, preparation method, and nature of the metal (leachability and rate of complex formation or interaction with other components) (Ashu and Chandravanshi 2011; da Silva et al. 2017; Jeszka-Skowron et al. 2016; Welna et al. 2013; Winiarska-Mieczan et al. 2021).
Concentration of As
As, a widespread toxic environmental contaminant, enters into the environment (air, water, and soil) through natural and anthropogenic (mainly pesticides used in agricultural practices) sources and is found in the natural world in organic, inorganic, and gaseous forms (Fu and Xi 2020; Petrović et al. 2020). Inorganic and gaseous forms of As are highly toxic, while organic As is considered relatively non-toxic in very low concentrations (Pullella and Kotsopoulos 2020). Exposure to As is of great concern. It has been related to adverse health effects, including cancer (skin, bladder, and lungs), damaged neurological growth, cardiovascular disorder, and diabetes (Pullella and Kotsopoulos 2020).
The rank order of countries based on the concentration of As in the coffee products was observed in the following: Brazil (178.882 µg/kg) > Netherland (74.981 µg/kg) > Greece (40.000 µg/kg) > Austria (20.050 µg/kg) > France (16.451 µg/kg) > Turkey (10.000 µg/kg) > Ethiopia (6.000 µg/kg) > Italy (1.250 µg/kg) > Germany (0.259 µg/kg) > Indonesia (0.100 µg/kg) ~ Romania (0.100 µg/kg) ~ Rwanda (0.100 µg/kg) ~ Slovenia (0.100 µg/kg) ~ Western Balkan (0.100 µg/kg) (Table 1). Since the maximum permitted level (MPL) of As in coffee is 1000 µg/kg (Petrović et al. 2020), it could be concluded that the As concentration of coffee products in all investigated countries does not show a risk to human health concerning this metal.
Concentration of Ni
Ni is naturally present in the soil and widespread distribution in the environment (Genchi et al. 2020). This metal has commercial and industrial applications, including metallurgy, electronics, batteries, jet turbines, and medical tools (Şaylan et al. 2020). As an essential element for all living things, Ni has several beneficial impacts on different body organs’ functions and metabolism, up to the permitted level. In this regard, Ni influences the liver and pancreas performances, the Fe absorption/metabolism, and the hematopoietic process (Gogoasa et al. 2013). However, in elevated concentrations, Ni can be dangerous for human health by creating respiratory disorders, including lung embolism, respiratory malfunction, asthma, chronic bronchitis, and allergic reactions (Nędzarek et al. 2013). As high long-time exposure to Ni is related to the development of different kinds of cancer such as lung, larynx, and prostate, it is recognized by the International Agency for Research on Cancer (IARC) as a carcinogen (Nędzarek et al. 2013; Voica et al. 2016).
The rank order of countries based on the concentration of Ni in the coffee products was as follows: Turkey (9695.861 µg/kg) > France (8615.085 µg/kg) > Netherland (5881.104 µg/kg) > India (3665.463 µg/kg) > Italy (2846.081 µg/kg) > Greece (2540.000 µg/kg) > Austria (2274.536 µg/kg) > Romania (1782.844 µg/kg) > Kenya (1630.881 µg/kg) > Brazil (1128.809 µg/kg) > Poland (1046.963 µg/kg) > Lebanon (842.300 µg/kg) > Bosnia (780.000 µg/kg) > Ethiopia (777.455 µg/kg) > Honduras (580.784 µg/kg) > Pakistan (410.000 µg/kg) > Hawaii (356.879 µg/kg) > Colombia (34.796 µg/kg) > Germany (5.047 µg/kg) > Western Balkan (4.471 µg/kg) > Slovenia (0.100 µg/kg) (Table 2).
There is no MPL for Ni in coffee beans, although Brazilian legislation authorizes an MPL of 5000 µg/kg for Ni in typical foods (da Silva et al. 2017; Pigozzi et al. 2018). Our results showed that the Ni concentrations in the coffee samples of all countries do not surpass this maximum level except for the coffee samples of Turkey, France, and the Netherland.
Concentration of Cr
Both kinds of Cr (Cr3+ and Cr6+) could enter the air, water, and soil through natural processes and industrial activities (like steel, leather, chemical, electronic, painting, and textile manufacturing) (Teklay 2016). Cr3+, an essential element in the body, influences metabolism by adjusting blood sugar levels in relatively small amounts (Gogoasa et al. 2013; Nędzarek et al. 2013). It is worth noting that Cr6+ is more active and toxic than Cr3+. This element occurs at many high levels in industrial activities, which could release Cr6+ into the environment (Achmad and Auerkari 2017). However, Cr3+ is ubiquitous in the environment (water and soil) and biological systems (Voica et al. 2016). It is reported that exposure to a high concentration of Cr could result in several physiological effects, including skin harm; respiratory injuries; gastrointestinal disorders; cardiovascular diseases; hepatic failure; carcinogenic, genotoxic, and neurotoxic mutagenic effects; and reproductive and developmental toxicity (Teklay 2016).
The rank order of countries based on the concentration of Cr in the coffee products was as follows: Netherland (34,000.000 µg/kg) > France (20,000.000 µg/kg) > Egypt (2500.000 µg/kg) > Kenya (714.922 µg/kg) > India (610.321 µg/kg) > Indonesia (600.000 µg/kg) > Honduras (290.000 µg/kg) > Ethiopia (246.854 µg/kg) > Hawaii (239.039 µg/kg) > Brazil (150.930 µg/kg) > Colombia (121.610 µg/kg) > Poland (60.000 µg/kg) > Bosnia (40.000 µg/kg) > Lebanon (35.000 µg/kg) > Germany (0.643 µg/kg) > Italy (0.134 µg/kg) > Austria (0.100 µg/kg) ~ Greece (0.100 µg/kg) (Table 3).
Similar to Ni, there are no reported maximum levels for the existence of the Cr metal in coffee products. At the same time, Brazilian regulation has established an MPL of 100 µg/kg for this element in the food (da Silva et al. 2017). Our results showed that the pooled concentrations of Cr in coffee products of all investigated countries exceed the maximum permitted level except Poland, Bosnia, Lebanon, Germany, Italy, Austria, and Greece.
Concentration of Cu
Cu is a vital element in numerous human body functions like antioxidant defense, Fe metabolism, enzyme functions, energy production, bone formation, and skin health in trace amounts (Bost et al. 2016; Gogoasa et al. 2017). Furthermore, lacking Cu may cause anemia, hair whitening, and bone distortion (Petrović et al. 2020). However, exposure to high concentrations of Cu is toxic and could result in stomach pain, nausea, diarrhea, peroxidation of macromolecules, and tissue injury (Anosike and Oranusi 2018; Bost et al. 2016).
The rank order of countries based on the concentration of Cu in the coffee products was Germany (38,000.000 µg/kg) > Austria (20,000.000 µg/kg) > Kenya (19,000.000 µg/kg) ~ Netherland (19,000.000 µg/kg) > Honduras (17,000.000 µg/kg) > India (14,000.000 µg/kg) > Colombia (13,000.000 µg/kg) ~ Costa Rica (13,000.000 µg/kg) ~ Guatemala (13,000.000 µg/kg) ~ Poland (13,000.000 µg/kg) > Nicaragua (12,000.000 µg/kg) > Peru (12,000.000 µg/kg) > Ethiopia (9097.608 µg/kg) > Italy (6598.028 µg/kg) > Greece (6520.000 µg/kg) > Nigeria (3970.000 µg/kg) > France (3538.513 µg/kg) > Brazil (2804.322 µg/kg) > Egypt (2200.000 µg/kg) > Hawaii (146.762 µg/kg) > Indonesia (90.000 µg/kg) (Table 4).
Our results showed that the concentrations of Cu in coffee products of all studied countries meet the MPL for Cu, determined by Brazilian legislation (30,000 µg/kg) (Alkherraz et al. 2019; Anosike and Oranusi 2018), except in Germany. Cu is usually used in the composition of some pesticides used in coffee fields as an active substance in different forms (Pigozzi et al. 2018). It is necessary for plant growth and is absorbed by plants during cultivation. Senkondo et al. (2014) observed that Cu concentrations in the coffee samples grown in the Cu-based pesticide soils were much higher compared with those in untreated soils, probably due to more availability of Cu for plant uptake, which could be the main reason for observed differences in Cu concentrations in different countries in the present study. However, the soil properties, climate conditions, and differences in coffee bean varieties are also influential factors (Alkherraz et al. 2019; Senkondo et al. 2014).
Concentration of Co
Co, another essential element, is a constituent of vitamin B12, which is vital in creating red blood cells (RBCs). It also participates in the appropriate functions of the nervous system, the self-defense of the body, activation of specific enzymes, and prevention of anemia (Gogoasa et al. 2013; Voica et al. 2016). However, a high Co intake could produce toxic effects on human and animal health, especially in the heart and liver (Nędzarek et al. 2013; Zoroddu et al. 2019).
The rank order of countries based on the concentration of Co in the coffee products was Ethiopia (2686.563 µg/kg) > France (865.526 µg/kg) > Austria (589.968 µg/kg) > Poland (428.061 µg/kg) > Italy (419.919 µg/kg) > Netherland (314.897 µg/kg) > Germany (308.238 µg/kg) > Hawaii (221.329 µg/kg) > Turkey (140.000 µg/kg) > Slovenia (124.982 µg/kg) > Greece (110.000 µg/kg) > Lebanon (66.000 µg/kg) > Bosnia (60.000 µg/kg) > Brazil (34.913 µg/kg) > Romania (0.102 µg/kg) (Table 5). There are no safety limits established for Co concentration in coffee products. However, there is an MPL of 10 µg/kg for this element in tea (Yaqub et al. 2018). Our results revealed that Co concentration in coffee samples of all countries is above this limit (except Romania), representing possible health risks to the population through coffee consumption.
Concentration of Cd
Cd is the most toxic PTE (Gogoasa et al. 2013; Voica et al. 2016). Research has not revealed any positive impacts of Cd on human and animal health (Alkherraz et al. 2019), while they could be exposed to Cd through food and water consumption or work conditions. This element could accumulate a high amount in the human organs during lifespan. It is detrimental to kidney function and could raise bone demineralization, even at low concentrations. Cd also could cause lung cancer with long-term exposure (Alkherraz et al. 2019). Given its water solubility trait, Cd could be released and spread quickly to the environment through natural rock weathering, agricultural practices, and industrial activities, including batteries, refining ores, metal alloys, and plastic, dye, ceramic, and glass production. This element is also present in phosphate manures and pesticides at small levels and subsequently could be taken up by plants from treated soils with such compounds (Alkherraz et al. 2019).
The rank order of countries based on the concentration of Cd in the coffee products was Indonesia (300.000 µg/kg) > Brazil (61.541 µg/kg) > Honduras (50.000 µg/kg) > India (40.000 µg/kg) > Colombia (25.010 µg/kg) > Poland (13.000 µg/kg) > Kenya (10.000 µg/kg) > Netherland (5.041 µg/kg) > Italy (1.160 µg/kg) > Germany (0.676 µg/kg) > Ethiopia (0.183 µg/kg) > Austria (0.100 µg/kg) ~ France (0.100 µg/kg) ~ Greece (0.100 µg/kg) ~ Jamaica (0.100 µg/kg) ~ Lebanon (0.100 µg/kg) ~ Malawi (0.100 µg/kg) ~ Pakistan (0.100 µg/kg) (Table 6).
The MPL for Cd set by the European Union (EU) is 100 µg/kg in coffee products (da Silva et al. 2017). The results showed that the pooled concentration of Cd in coffee products of all studied countries meets the regulation limit except Indonesia.
To this end, geographical location in waste zones and industrial units that release Cd to the environment are critical in Cd concentration in food products. In this regard, synthetic fertilizers in farming sections, contaminated water, and agricultural fields with Cd could increase human exposure to this toxic element through food consumption (Fu and Xi 2020; Hocaoğlu-Özyiğit and Genç 2020).
Concentration of Pb
Pb, another highly toxic element, could accumulate in the body (Gogoasa et al. 2013). It is a non-essential metal for living things (Wadhwa et al. 2014). Pb is present everywhere in the environment (Lee et al. 2020). Plants like coffee beans could easily absorb Pb from the soil, water, and air (Lee et al. 2020). The significant harmful effects of these PTEs on human and animal health are carcinogenicity, neurotoxicity, hepatotoxicity, endocrine toxicity, reproductive and developmental toxicity, cardiovascular diseases, and gastrointestinal and hepatic disorders (da Silva et al. 2017; Pigozzi et al. 2018).
The rank order of countries based on the concentration of Pd in the coffee products was Indonesia (3900.000 µg/kg) > Syria (2492.013 µg/kg) > Egypt (1900.000 µg/kg) > Bosnia (1050.000 µg/kg) > Lebanon (693.000 µg/kg) > Austria (350.000 µg/kg) > Netherland (274.986 µg/kg) > Italy (221.898 µg/kg) > Brazil (203.618 µg/kg) > Greece (200.000 µg/kg) > Germany (183.279 µg/kg) > Turkey (120.000 µg/kg) > India (92.630 µg/kg) > Slovenia (70.000 µg/kg) > Poland (60.934 µg/kg) > France (23.829 µg/kg) > Pakistan (20.000 µg/kg) > Honduras (15.039 µg/kg) > Colombia (13.48 µg/kg) > Kenya (9.949 µg/kg) > Hawaii (8.895 µg/kg) > Romania (0.459 µg/kg) > South Korea (0.240 µg/kg) > Western Balkan (0.137 µg/kg) > Ethiopia (0.104 µg/kg) (Table 7).
Polish food legislation, Brazilian legislation, and the EU have set the MPLs for Pb in coffee products as 1000 µg/kg, 500 µg/kg, and 200 µg/kg, respectively (Albals et al. 2021; Azam et al. 2021; Jeszka-Skowron et al. 2016). It could be concluded that the investigated coffees of all countries are not dangerous to human health except for Indonesia, Syria, Egypt, and Bosnia. However, using Brazil and EU safe limits, one country (Lebanon) and 5 other countries (Lebanon, Austria, Netherland, Italy, Brazil, and Greece) do not meet these regulation limits, respectively.
As observed previously, there are high differences between pooled concentrations of all PTEs in coffee products of different countries. Different factors are influential in these differences, which are discussed in the following.
First of all, coffee characteristics include variety, species (Arabica or Robusta), ripeness, type (brand/raw or roasted/ground or instant/infusion or powder), size, and processing conditions such as grinding, drying, roasting, mixing, and brewing methods which are effective in the observed difference in the content of PTEs in coffee products in different countries (Albals et al. 2021; Gure et al. 2017). Furthermore, the origin of the coffee regarding environmental conditions, including soil properties (type of soil, organic matter concentration, pH, drainage grade), geographical location (climate condition), and agricultural practices (using fertilizers and pesticides, organic or conventional farming), has a crucial impact on the content of PTEs in coffee beans (da Silva et al. 2017; Habte et al. 2016).
It is worth noting that both PTEs’ gains and losses may occur during coffee processing which can be another source of observed differences in their concentration in different countries. The type of water used for infusion is also effective (Ashu and Chandravanshi 2011). In the case of the type of coffee products, it is reported that mixtures of coffee substitutes or surrogates (cereal grains) with coffee (20–66%) intermediate exhibit contents. At the same time, lower amounts are determined in coffee surrogates without coffee addition (Oliveira et al. 2012).
In the case of the brewing method, it is reported that the extraction levels of most PTEs are highest in the Turkish coffee method, in which coffee is boiled together with water (Nędzarek et al. 2013; Şemen et al. 2017). Regarding the type of coffee in terms of raw or roasted, it is noteworthy that the concentrations of PTEs in green coffee are typically lower than those determined in roasted coffees, probably due to removing water and volatile constituents (Amorim Filho et al. 2007; da Silva et al. 2017). Moreover, Şemen et al. (2017) concluded that studied PTEs are leached to the infusion more difficult from roasted coffee than from green coffee. Ashu and Chandravanshi (2011) also observed that the infusions contain lower PTEs than the roasted coffee. Moreover, Welna et al. (2013) noted that the transfer degree of PTEs into brew might vary probably related to coffee type (instant and ground coffees). Amorim Filho et al. (2007) also observed that the concentration of Fe and Cr is highest in steel grinders because of releasing these metals into the coffee samples via the mill overheating. Additionally, Nędzarek et al. (2013) reported that potential contamination with PTEs may originate from packaging materials containing metals during coffee storage. There is also a negative relationship between the size of the coffee powder and the extraction rate of PTEs into the infusion (Pigozzi et al. 2018).
Moreover, Ashu and Chandravanshi (2011) reported that the concentration of PTEs in coffee varies among coffee varieties cultivated in diverse parts of the world with different environments, soil, and fertilizers.
Further, differences in sampling, sample preparation, and analytical techniques used in different studies significantly impact the concentration of PTEs (Ashu and Chandravanshi 2011). The contents of PTEs in the ground coffee are different from those in instant (soluble) coffee, probably due to processing differences (Voica et al. 2016). There are different kinds of methods used for the determination of PTEs in coffee products, including atomic absorption spectrometry (AAS), inductively coupled plasma-optical emission spectrometry (ICP-OES), inductively coupled plasma-mass spectroscopy (ICP-MS), atomic fluorescence spectrometry (AFS), and electrodes. Among these methods, ICP-OES and ICP-MS are the most remarkably applied because of their high sensitivity, specificity, selectivity, low detection limits (LODs), ease of setup, less time, and low cost (Albals et al. 2021; Alkherraz et al. 2019). However, to overcome the disadvantages of AFS methods, some pre-concentration methods could be utilized during sample preparation, including solid-phase extraction (SPE), liquid–liquid extraction (LLE), as well as microextraction procedures like dispersive liquid–liquid microextraction (DLLME) (Şaylan et al. 2020).
Conclusion
This study meta-analyzed the prevalence of potentially toxic elements in coffee products in different countries. The pooled mean concentration of essential elements in coffee products is much higher than that of toxic elements (Co > Ni > Cu > Cr > Pb > As > Cd). The result showed that the pooled mean concentration of essential elements in coffee products is much higher than that of toxic elements. Also, high differences between pooled concentrations of all PTEs were reported in coffee products of different countries. Various concentrations of potentially toxic elements in different studies may be due to several factors, including environmental growth conditions (climate, temperature, and agricultural practices), type of processing, coffee variety, preparation method, agricultural practices (using fertilizers and pesticides, organic or conventional farming), and analytical techniques. Therefore, more studies are needed to investigate the effect of mentioned factors on the prevalence of PTEs in coffee products in the future.
Data availability
Not applicable.
References
Achmad RT, Auerkari EI (2017) Effects of chromium on human body. Ann Res Rev Biol 13:1–8
Albals D, Al-Momani IF, Issa R, Yehya A (2021) Multi-element determination of essential and toxic metals in green and roasted coffee beans: a comparative study among different origins using ICP-MS. Sci Prog 104:00368504211026162
Alkherraz A, Hashad O, Elsherif K (2019) Heavy metals contents in some commercially available coffee, tea, and cocoa samples in Misurata City -Libya. Prog Chem Biochem Res 2:99–107
Ameri Z, Hoodaji M, Rajaie M, Ataabadi M (2021) Optimizing modified rice bran for treating aqueous solutions polluted by Cr (VI) ions: isotherm and kinetics analyses. Qual Assur Saf Crops Foods 13:1–11
Amorim Filho VR, Polito WL, Gomes Neto JA (2007) Comparative studies of the sample decomposition of green and roasted coffee for determination of nutrients and data exploratory analysis. J Braz Chem Soc 18:47–53
Anosike S, Oranusi S (2018) Assessment of microbiological and chemical qualities of selected cocoa, tea and coffee brands in Nigerian markets. Afr J Clin Exp Microbiol 19:186–194
Ashu R, Chandravanshi BS (2011) Concentration levels of metals in commercially available Ethiopian roasted coffee powders and their infusions. Bull Chem Soc Ethiopia. https://doi.org/10.4314/bcse.v25i1.63356
Atamaleki A, Sadani M, Raoofi A, Miri A, Bajestani SG, Fakhri Y, Heidarinejad Z, Khaneghah AM (2020) The concentration of potentially toxic elements (PTEs) in eggs: a global systematic review, meta-analysis and probabilistic health risk assessment. Trends Food Sci Technol 95:1–9
Azam K, Akhtar S, Gong YY, Routledge MN, Ismail A, Oliveira CA, Iqbal SZ, Ali H (2021) Evaluation of the impact of activated carbon-based filtration system on the concentration of aflatoxins and selected heavy metals in roasted coffee. Food Control 121:107583
Barbosa RM, Batista BL, Varrique RM, Coelho VA, Campiglia AD, Barbosa F Jr (2014) The use of advanced chemometric techniques and trace element levels for controlling the authenticity of organic coffee. Food Res Int 61:246–251
Barrea L, Pugliese G, Frias-Toral E, El Ghoch M, Castellucci B, Chapela SP, Carignano MdlA, Laudisio D, Savastano S, Colao A (2021) Coffee consumption, health benefits and side effects: a narrative review and update for dietitians and nutritionists. Crit Rev Food Sci Nutr 1–24
Batrinou A, Houhoula D, Papageorgiou E (2020) Rapid detection of mycotoxins on foods and beverages with enzyme-linked immunosorbent assay. Qual Assur Saf Crops Foods 12:40–49
Berman N, Honig S, Cronstein B, Pillinger M (2022) The effects of caffeine on bone mineral density and fracture risk. Osteoporos Int 33:1235–1241
Bost M, Houdart S, Oberli M, Kalonji E, Huneau J-F, Margaritis I (2016) Dietary copper and human health: current evidence and unresolved issues. J Trace Elem Med Biol 35:107–115
Bounar A, Boukaka K, Leghouchi E (2020) Determination of heavy metals in tomatoes cultivated under green houses and human health risk assessment. Qual Assur Saf Crops Foods 12:76–86
da Silva SA, Mendes F, Queiroz I, Reis MR, Passos FR, de Carvalho AMX, de Oliveira Rocha KR, Pinto FG (2017) Determination of heavy metals in the roasted and ground coffee beans and brew. Afr J Agric Res 12:221-228
de Mejia EG, Ramirez-Mares MV (2014) Impact of caffeine and coffee on our health. Trends Endocrinol Metab 25:489–492
Delgado Quezada V, Altamirano Espinoza M, Bundschuh J (2020) Arsenic in geoenvironments of Nicaragua: exposure, health effects, mitigation and future needs. Sci Total Environ 716:136527
Dieng H, Ellias SB, Satho T, Ahmad AH, Abang F, Ghani IA, Noor S, Ahmad H, Zuharah WF, Morales Vargas RE (2017) Coffee, its roasted form, and their residues cause birth failure and shorten lifespan in dengue vectors. Environ Sci Pollut Res 24:14782–14794
Escott-Stump S (2008) Nutrition and diagnosis-related care. Lippincott Williams & Wilkins
Fu Z, Xi S (2020) The effects of heavy metals on human metabolism. Toxicol Mech Methods 30:167–176
Gao L, Huang X, Wang P, Chen Z, Hao Q, Bai S, Tang S, Li C, Qin D (2022) Concentrations and health risk assessment of 24 residual heavy metals in Chinese mitten crab (Eriocheir sinensis). Qual Assur Saf Crops Foods 14:82–91
Genchi G, Carocci A, Lauria G, Sinicropi MS, Catalano A (2020) Nickel: human health and environmental toxicology. Int J Environ Res Public Health 17:679
Godos J, Pluchinotta FR, Marventano S, Buscemi S, Li Volti G, Galvano F, Grosso G (2014) Coffee components and cardiovascular risk: beneficial and detrimental effects. Int J Food Sci Nutr 65:925–936
Gogoasa I, Pirvu A, Alda L, Velciov A, Rada M, Bordean D, Moigradean D, Simion A, Gergen I (2013) The mineral content of different coffee brands. J Hortic For Biotechnol 17:68–71
Gogoasa I, Adina B, Adina N, Maria R, Antoanela C, Liana A (2017) Determination of trace elements in commercially available instant coffees. J Hortic For Biotechnol 21:1–5
Guan Q, Zeng G, Song J, Liu C, Wang Z, Wu S (2021) Ultrasonic power combined with seed materials for recovery of phosphorus from swine wastewater via struvite crystallization process. J Environ Manage 293:112961
Gure A, Chandravanshi BS, Godeto TW (2017) Metals in green coffee beans from major coffee-growing regions of Ethiopia. Chem Int 3:359–369
Habte G, Hwang IM, Kim JS, Hong JH, Hong YS, Choi JY, Nho EY, Jamila N, Khan N, Kim KS (2016) Elemental profiling and geographical differentiation of Ethiopian coffee samples through inductively coupled plasma-optical emission spectroscopy (ICP-OES), ICP-mass spectrometry (ICP-MS) and direct mercury analyzer (DMA). Food Chem 212:512–520
Heshmati A, Mehri F, Karami-Momtaz J, Khaneghah AM (2020) The concentration and health risk of potentially toxic elements in black and green tea—both bagged and loose-leaf. Qual Assur Saf Crops Foods 12:140–150
Higgins JPT, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21:1539–1558
Higgins J, White IR, Anzures-Cabrera J (2008) Meta-analysis of skewed data: combining results reported on log-transformed or raw scales. Stat Med 27:6072–6092
Hocaoğlu-Özyiğit A, Genç BN (2020) Cadmium in plants, humans and the environment. Front Life Sci Relat Technol 1:12-21
Hu L, Wang X, Zou Y, Wu D, Gao G, Zhong Z, Liu Y, Hu S, Fan H, Zhang B (2022) Effects of inorganic and organic selenium intervention on resistance of radish to arsenic stress. Ital J Food Sci 34:44–58
Ibrahem S, Hassan M, Ibraheem Q, Arif K (2020) Genotoxic effect of lead and cadmium on workers at wastewater plant in Iraq. J Environ Public Health 20:1–9
Jeszka-Skowron M, Stanisz E, De Peña MP (2016) Relationship between antioxidant capacity, chlorogenic acids and elemental composition of green coffee. LWT 73:243–250
Kalita J, Kumar V, Misra UK, Bora HK (2019) Movement disorder in copper toxicity rat model: role of inflammation and apoptosis in the corpus striatum. Neurotox Res 37:904–912
Khan KM, Chakraborty R, Bundschuh J, Bhattacharya P, Parvez F (2020) Health effects of arsenic exposure in Latin America: an overview of the past eight years of research. Sci Total Environ 710:136071
Khaneghah AM, Fakhri Y, Abdi L, Coppa CFSC, Franco LT, de Oliveira CAF (2019) The concentration and prevalence of ochratoxin A in coffee and coffee-based products: a global systematic review, meta-analysis and meta-regression. Fungal Biol 123:611–617
Khaneghah AM, Fakhri Y, Nematollahi A, Pirhadi M (2020) Potentially toxic elements (PTEs) in cereal-based foods: a systematic review and meta-analysis. Trends Food Sci Technol 96:30–44
Lee J-G, Hwang J-Y, Lee H-E, Choi J-D, Kang G-J (2020) Comparative analysis of lead content during food processing. Food Sci Biotechnol 29:1063–1069
Li W, Shi Y, Zhu D, Wang W, Liu H, Li J, Shi N, Ma L, Fu S (2021) Fine root biomass and morphology in a temperate forest are influenced more by the nitrogen treatment approach than the rate. Ecol Ind 130:108031
Lin X, Lu K, Hardison AK, Liu Z, Xu X, Gao D, Gong J, Gardner WS (2021) Membrane inlet mass spectrometry method (REOX/MIMS) to measure 15N-nitrate in isotope-enrichment experiments. Ecol Ind 126:107639
Liu W, Huang F, Wang Y, Zou T, Zheng J, Lin Z (2011) Recycling Mg(OH)2 nanoadsorbent during treating the low concentration of CrVI. Environ Sci Technol 45:1955–1961
Liu W, Li J, Zheng J, Song Y, Shi Z, Lin Z, Chai L (2020) Different pathways for Cr(III) oxidation: implications for Cr(VI) reoccurrence in reduced chromite ore processing residue. Environ Sci Technol 54:11971–11979
Liu G, Nie R, Liu Y, Mehmood A (2022) Combined antimicrobial effect of bacteriocins with other hurdles of physicochemic and microbiome to prolong shelf life of food: a review. Sci Total Environ 825:154058
Martineli L, da Silva Berilli S, Amaro de Sales R, da Cunha M, Monaco PAVL, de Jesus Freitas S, Martineli M, Gabriel Berilli APC, Pireda S, da Silva Oliveira D (2022) Influence of chromium and sodium on development, physiology, and anatomy of Conilon coffee seedlings. Environ Sci Pollut Res 29:44986–44997
Mirmahdi RS, Zoghi A, Mohammadi F, Khosravi-Darani K, Jazaiery S, Mohammadi R, Rehman Y (2021) Biodecontamination of milk and dairy products by probiotics: boon for bane. Ital J Food Sci 33:78–91
Mirmahdi RS, Mofid V, Zoghi A, Khosravi_Darani K, Mortazavian AM (2022) Risk of low stability Saccharomyces cerevisiae ATCC 9763-heavy metals complex in gastrointestinal simulated conditions. Heliyon 8:e09452
Moher D, Liberati A, Tetzlaff J, Altman DG, Group P (2010) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg 8:336-341
Nartea A, Lucci P, Loizzo MR, Tundis R, Leporini M, Gervasi L, Fanesi B, Núñez O, Frega NG, Fiorini D (2022) Is coffee powder extract a possible functional ingredient useful in food and nutraceutical industries? Ital J Food Sci 34:140–148
Nędzarek A, Tórz A, Karakiewicz B, Clark JS, Laszczyńska M, Kaleta A, Adler G (2013) Concentrations of heavy metals (Mn, Co, Ni, Cr, Ag, Pb) in coffee. Acta Biochim Pol 60:623–627
Nourbakhsh F, Tajbakhsh E (2021) Neurotoxicity mechanism of ochratoxin A. Qual Assur Saf Crops Foods 13:34–45
Oliveira M, Casal S, Morais S, Alves C, Dias F, Ramos S, Mendes E, Delerue-Matos C, Oliveira MBP (2012) Intra-and interspecific mineral composition variability of commercial instant coffees and coffee substitutes: contribution to mineral intake. Food Chem 130:702–709
Pavithra V (2021) Review article on caffeine activity. J Nanotechnol Res 3:1–5
Petrović SM, Savić SR, Zvezdanović JB, Mladenović-Ranisavljević I, Cvetković DJ, Cvetanović AD (2020) Benefits and risks of commercially available coffee beverages from Western Balkan. Chem Pap 74:847–857
Pigozzi MT, Passos FR, Mendes FQ (2018) Quality of commercial coffees: heavy metal and ash contents. J Food Qual 2018:1–8
Pohl P, Stelmach E, Szymczycha-Madeja A (2014) Simplified sample treatment for the determination of total concentrations and chemical fractionation forms of Ca, Fe, Mg and Mn in soluble coffees. Food Chem 163:31–36
Pullella K, Kotsopoulos J (2020) Arsenic exposure and breast cancer risk: a re-evaluation of the literature. Nutrients 12:3305
Quan H, Zhang J (2003) Estimate of standard deviation for a log-transformed variable using arithmetic means and standard deviations. Stat Med 22:2723–2736
Quan Q, Gao S, Shang Y, Wang B (2021) Assessment of the sustainability of Gymnocypris eckloni habitat under river damming in the source region of the Yellow River. Sci Total Environ 778:146312
Rattan S, Parande AK, Nagaraju VD, Ghiwari GK (2015) A comprehensive review on utilization of wastewater from coffee processing. Environ Sci Pollut Res 22:6461–6472
Samet M, Charfeddine M, Kamoun L, Nouri-Ellouze O, Gargouri-Bouzid R (2018) Effect of compost tea containing phosphogypsum on potato plant growth and protection against Fusarium solani infection. Environ Sci Pollut Res 25:18921–18937
Şaylan M, Zaman BT, Bakırdere EG, Bakırdere S (2020) Determination of trace nickel in chamomile tea and coffee samples by slotted quartz tube-flame atomic absorption spectrometry after preconcentration with dispersive liquid-liquid microextraction method using a Schiff base ligand. J Food Compos Anal 88:103454
Şemen S, Mercan S, Yayla M, Açıkkol M (2017) Elemental composition of green coffee and its contribution to dietary intake. Food Chem 215:92–100
Senkondo YH, Tack F, Semu E (2014) Copper accumulations in soils, coffee, banana, and bean plants following copper-based fungicides in coffee farms in Arusha and Kilimanjaro regions, Tanzania. Commun Soil Sci Plant Anal 45:2032–2045
Shi C, Wu Z, Yang F, Tang Y (2021) Janus particles with pH switchable properties for high-efficiency adsorption of PPCPs in water. Solid State Sci 119:106702
Sun Y, Li J, Zhu L, Jiang L (2022) Cooperation and competition between CRISPR-and omics-based technologies in foodborne pathogens detection: a state of the art review. Curr Opin Food Sci 44:100813
Teklay A (2016) Physiological effect of chromium exposure: a review. Int J Food Sci Nutr Diet S 7:1–11
Tiep TD (2014) Effect of roasting conditions on concentration in elements of Vietnam robusta coffee. Acta Univ Cibiniesis E Food Technol 18:19–34
van Dam RM, Hu FB, Willett WC (2020) Coffee, caffeine, and health. N Engl J Med 383:369–378
Voica C, Feher I, Iordache A, Cristea G, Dehelean A, Magdas D, Mirel V (2016) Multielemental analysis of coffee by inductively coupled plasma-mass spectrometry. Anal Lett 49:2627–2643
Wadhwa SK, Tuzen M, Kazi TG, Soylak M, Hazer B (2014) Polyhydroxybutyrate-b-polyethyleneglycol block copolymer for the solid phase extraction of lead and copper in water, baby foods, tea and coffee samples. Food Chem 152:75–80
Wang Y, Wu X, Liu J, Zhai Z, Yang Z, Xia J, Deng S, Qu X, Zhang H, Wu D (2022) Mo-modified band structure and enhanced photocatalytic properties of tin oxide quantum dots for visible-light driven degradation of antibiotic contaminants. J Environ Chem Eng 10:107091
Welna M, Szymczycha-Madeja A, Zyrnicki W (2013) Applicability of ICP-OES, UV-VIS, and FT-IR methods for the analysis of coffee products. Anal Lett 46:2927–2940
Winiarska-Mieczan A, Kwiatkowska K, Kwiecień M, Zaricka E (2021) Assessment of the risk of exposure to cadmium and lead as a result of the consumption of coffee infusions. Biol Trace Elem Res 199:2420–2428
Wolde T (2014) Effects of caffeine on health and nutrition: a review. Food Sci Qual Manag 30:59–65
World Health Organization (2000) Evaluation of certain food additives and contaminants: fifty-third report of the Joint FAO/WHO Expert Committee on Food Additives. World Health Organization, Geneva
Yaqub G, Ilyas F, Idrees M, Mariyam V (2018) Monitoring and risk assessment due to presence of heavy metals and pesticides in tea samples. Food Sci Technol 38:625–628
Yazdanpanah S, Jokar S, Zandilak T, Haghighi M (2022) Evaluation and comparison of ochratoxin a contamination and metallic elements lead and arsenic in commercial instant coffee powders. Iran Food Sci Technol Res J 18:81–95
Zoroddu MA, Aaseth J, Crisponi G, Medici S, Peana M, Nurchi VM (2019) The essential metals for humans: a brief overview. J Inorg Biochem 195:120–129
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Trias Mahmudiono, Fardin Javanmardi, and Behrouz Tajdar-oranj: investigation, data curation, resources, conceptualization, methodology, and writing of original draft. Amene Nematollahi and Mohadeseh Pirhadi: literature searching, writing, and editing. Amin Mousavi Khaneghah and Yadolah Fakhri: supervision, conceptualization, data analysis, and review and editing.
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Mousavi Khaneghah, A., Mahmudiono, T., Javanmardi, F. et al. The concentration of potentially toxic elements (PTEs) in the coffee products: a systematic review and meta-analysis. Environ Sci Pollut Res 29, 78152–78164 (2022). https://doi.org/10.1007/s11356-022-23110-9
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DOI: https://doi.org/10.1007/s11356-022-23110-9