Abstract
The distribution of complexes of thiazine and pyrimidine derivatives possessing antileukemic activity and labeled with radionuclide 69mZn in the organs of mice and its rate of excretion were studied. A solution of ZnCl2 was used for comparison. An increase in the time of excretion of the drug from the body and a decrease of its penetration into the brain in the presence of a salicylate ion were observed.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1542–1543, August, 2018.
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Orlova, M.A., Trofimova, T.P., Aleshin, G.Y. et al. The distribution of complexes 69mZnL1Cl2, [69mZn(L2)2]Cl2, and [69mZn(L2)2]Sal2 (L1 is N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide, L2 is 2-aminopyrimidine, Sal is a salicylate ion) in vivo in mice. Russ Chem Bull 67, 1542–1543 (2018). https://doi.org/10.1007/s11172-018-2254-9
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DOI: https://doi.org/10.1007/s11172-018-2254-9