Abstract
The distribution of the antitumor drug aurumacryl (intraperitoneally injected at a dose of 100 mg/kg) in the bodies of animals with Lewis lung carcinoma was studied. The determination of aurumacryl in the tumors and organs (blood, liver, kidneys, lungs, spleen, and brain) of mice was carried out for 48 h by measuring the gold content in the test tissues using inductively coupled plasma mass spectrometry. We found the preferential accumulation of the drug in the kidneys with an extremely low gold content in the brain and a relatively uniform distribution of aurumacryl between the tumor, liver, lung, and spleen tissues.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
Abbreviations
- ICP-MS:
-
inductively coupled plasma mass spectrometry
- RB:
-
relative bioavailability
References
D. B. Korman, Fundamentals of Antitumor Chemotherapy (Prakticheskaya Meditsina, Moscow, 2006) [in Russian].
V. N. Babin, Yu. A. Belousov, V. I. Borisov, et al., Izv. Akad. Nauk, Ser. Khim., No. 11, 2405 (2014).
I. A. Efimenko, Koordnats. Khim. 24 (4), 282 (1998).
M. Frezza, S. Hindo, D. Chen, et al., Curr. Pharmacol. Des. 16, 1813 (2010).
C. Nardon, F. Chiara, L. Brustolin, et al., Chem. Open 4, 183 (2015).
C. Nardon, N. Pettenuzzo, and D. Fregona, Curr. Med. Chem. 23, 3374 (2016).
L. Ronconi and D. Fregona, Dalton Trans. 48, 10670 (2009).
X. Chen, X. Shi, X. Wang, and J. Liu, Cancer Cell Microenviron. 1, 415, (2014).
D. Oomen and D. Yiannakis, Mutat. Res. 784–785, 8 (2015).
D. Saggioro, M.P. Rigobello, L. Paloschi, et al., Chem. Biol. 14, 1128 (2007).
S. Nobili, E. Mini, I. Landini, et al., Med. Res. Rev. 30, 550 (2010).
A. Markowska, B. Kasprzak, K. Jaszczynska-Nowinka, et al., Contemp. Oncol. (Poznan) 19, 271 (2015).
A. Casini and L. Messory, Curr. Top. Med. Chem. 11, 2647 (2011).
I. Kostova, Anticancer Agents Med. Chem. 6, 19 (2006).
E. Topkas, N. Gai, A. Cumming, et al., Oncotarget 7, 831 (2016).
V. Gandin, A. P. Ferhanes, and M. P. Rigobello, Biochem. Pharmacol. 79, 90 (2010).
L. Cattaruza, D. Fregona, M. Mongiat, et al. Int. J. Cancer 128, 202 (2011).
G. Marzano, V. Gandin, A. Fold, et al. Free Radic. Biol. Med. 42, 872 (2007).
M. G. Voronkov, K. A. Abzaeva, L. V. Zhilitskaya, et al., RF Patent No. 2372091 (May 20, 2008).
L. A. Ostrovskaya, M. G. Voronkov, D. B. Korman, et al., J. Cancer Ther. 1 (2), 59 (2010).
L. A. Ostrovskaya, D. B. Korman, N.V. Bluhterova, et al., Biointerface Res. Appl. Chem. 4 (4), 816 (2014).
L. A. Ostrovskaya, M. G. Voronkov, D. B. Korman, et al., Biophysics (Mosow) 59 (4), 642 (2014).
L. A. Ostrovskaya, A. K. Grehova, D. B. Korman, et al., Biophysics (Mosow) 62 (3), 485 (2017).
L. A. Ostrovskaya, D. B. Korman, A. K. Grehova, et al., Izv. Akad. Nauk, Ser. Khim., No. 12, 2333 (2017).
T. Suzuki, K. Sarai, K. Kohda, and Y. Kawazoe, Anticancer Res. 11 (2), 953 (1991).
N. A. Plate and E. A. Vasil’ev, Physiologically Active Polymers (Khimiya, Moscow, 1986) [in Russian].
E. M. Treshchalina, O. S. Zhukova, G. K. Gerasimova, et al., Guidelines for Experimental (Preclinical) Study of New Pharmacological Substances, Ed. by R. U. Khabriev (Meditsina, Moscow, 2005) [in Russian].
V. K. Karandashev, T. A. Orlova, A. E. Lezhnev, et al., Inorg. Mater. 44 (14), 1491 (2008).
H. Wickham, ggplot2: Elegant Graphics for Data Analysis (Springer, New York, 2009).
L. A. Ostrovskaya, V. A. Filov, B. A. Ivin, et al., Ross. Bioterapevt. Zh. 3 (1), 37 (2004).
E. V. Caparelli, R. Bricker-Ford, M. J. Rogers, et al. Antimicrob. Agents Chemother. 61 (1), e01947-16. (2017). doi doi 10.1128/AAC-01947-16
K. A. Abzaeva, L. V. Zhilitskaya, G. G. Belozerskaya, and L. A. Ostrovskaya, Izv. Akad. Nauk, Ser. Khim., No. 12, 2314 (2017).
Y. Liu, Y. Li, S. Yu, and G. Zhao, Curr. Drug Targets, 13, 1432 (2012).
S. M. Meier, C. Gerner, B. K. Keppler, et al., Inorg. Chem. 255, 4248 (2016).
X. Zhang, M. Frezza, V. Milacic, et al., J. Cell Biochem. 109, 162 (2010).
T. Zou, C. T. Lum, C. N. Loc, et al., Chem. Soc. Rev. 44, 8786 (2015).
S. Perez, C. deHaro, Vicente C., et al., ACS Chem. Biol. (2017). doi 10.1021/acschembio7600090
A. Casini, G. Kelter, C. Gabbiani, et al., J. Biol. Inorg. Chem. 14, 1139 (2009).
C. Gabbiani, A. Casini, G. Ketler, et al., Metallomics 3, 1318 (2011).
M. Celegato, D. Fregona, M. Mongiat, et al., Future Med. Chem. 6, 1249 (2014).
C. Nardon, G. Boscutti, and D. Fregona, Anticancer Res. 14, 487 (2014).
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © L.A. Ostrovskaya, D.B. Korman, J.P. Burmiy, V.A. Kuzmin, N.V. Bluhterova, M.M. Fomina, V.A. Rikova, R.R. Guliev, K.A. Abzaeva, 2018, published in Biofizika, 2018, Vol. 63, No. 3, pp. 606–614.
Rights and permissions
About this article
Cite this article
Ostrovskaya, L.A., Korman, D.B., Burmiy, J.P. et al. An Experimental Study of the Pharmacokinetics of the Antitumor Drug Aurumacryl. BIOPHYSICS 63, 469–476 (2018). https://doi.org/10.1134/S0006350918030181
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0006350918030181