Abstract
The surgical management of extremity bone and soft tissue sarcomas has evolved significantly over the last 50 years. The introduction and refinement of high-resolution cross-sectional imaging has allowed accurate assessment of anatomy and tumor extent, and in the current era more than 90% of patients can successfully undergo limb-salvage surgery. Advances in imaging have also revolutionized the clinician’s ability to assess treatment response, detect metastatic disease, and perform intraoperative surgical navigation. This review summarizes the broad and essential role radiology plays in caring for sarcoma patients from diagnosis to post-treatment surveillance. Present evidence-based imaging paradigms are highlighted along with key future directions.
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Introduction
Sarcomas constitute a heterogeneous group of neoplasms of mesenchymal origin. While they may arise in any area of the body with connective tissue, the majority of bone and soft tissue sarcomas arise in the extremities. The management of sarcoma patients is truly a multidisciplinary effort. While surgeons, radiation oncologists, and medical oncologists compose the core of the team, radiologists are essential partners in achieving successful clinical outcomes.
The surgical management of extremity bone and soft tissue sarcomas has evolved significantly over the last 50 years. Prior to 1980, amputation was the primary means of local disease control owing to the lack of advanced imaging and adjuvant therapies. The advent of high-resolution cross-sectional imaging allowed for detailed assessment of anatomic compartments, thereby improving the visualization of nearby neurovascular structures and satellite lesions, making limb-salvage resections feasible. As image resolution improved, the surgeon’s ability to preserve tissue and improve function followed. In conjunction with these imaging advances, the introduction of chemotherapy improved disease-free survival, and advances in radiation oncology further improved local control of soft tissue sarcomas. Currently, over 90% of patients with extremity sarcomas can be treated with limb-salvage surgery. This review summarizes the broad and essential role radiology plays in caring for sarcoma patients. Present evidence-based imaging paradigms are highlighted, along with key future directions.
Diagnosis
Radiographs
Radiographs are part of the initial evaluation of bone and soft tissue lesions [1]. While advanced imaging modalities, like MRI, continue to improve and are more accessible than ever, radiographs still provide valuable diagnostic information and should not be overlooked. For bone lesions, standard practice involves obtaining radiographs of the entire bone in two orthogonal projections with the adjacent joint. Key imaging features—including bone destruction pattern, zone of transition, cortical destruction, type of periosteal reaction, matrix and tumor mineralization, and soft tissue involvement—help differentiate indolent from aggressive bone tumors and identify a histologic character (Fig. 1) [2]. While radiographs are seldom diagnostic for soft-tissue lesions, they remain a key component of evaluating soft tissue tumors, many of which have distinctive patterns of mineralization. For example, hemangiomas may contain phleboliths, liposarcomas can contain large coarse calcifications, and synovial sarcomas tend to have coarse calcifications that are amorphous or spiculated [3]. Radiographs may also assist in identifying bony erosion from soft tissue sarcomas adjacent to the bone.
Magnetic resonance imaging
The American College of Radiology considers MRI to be the gold standard for the evaluation of soft tissue sarcomas of the extremity and for identifying bone marrow infiltration and tumor margins in osseous lesions [4]. MRI provides excellent tissue contrast resolution and anatomic information detailing the tumor’s relationship to nearby critical structures, especially with the advent of fast, high-resolution 3D volumetric sequences [1, 5, 6]. During imaging of suspected sarcomas, it is important for the protocol to include the entire anatomic compartment containing the tumor, to evaluate for skip lesions in the bone, multifocal disease, or tumor spread along fascial and vascular planes (Fig. 2) [7].
For the assessment of a bone tumor, an MRI protocol should include T1-weighted and fluid-sensitive sequences (typically with fat-suppressed T2-weighted or short tau inversion recovery imaging) to assess for tumor extent (by differentiating marrow replacement from normal marrow elements on T1-weighted images) and lesional character (by identifying aggressive features, such as perilesional edema, periosteal reaction, and soft tissue extension). The administration of gadolinium-based contrast agents further aids in the identification of solid tumor areas (differentiating them from cystic areas or areas of necrosis) (Fig. 3), and is a useful adjunct to identify hemorrhage and joint involvement [8]. When standard fast-spin echo T1-weighted imaging is inconclusive, a useful non-contrast fast technique is chemical shift imaging with in-phase and opposed-phase gradient echo imaging (the Dixon technique), which helps distinguish areas of marrow replacement from normal marrow elements or bone marrow edema (Fig. 4); this is an important technique for evaluating tumor extent and characterizing marrow signal abnormalities [9, 10]. In addition, functional imaging sequences with diffusion-weighted imaging (DWI) and dynamic contrast-enhanced (DCE) MRI are techniques that do not add significant time to the MRI protocol (Fig. 5), and provide information on tumor character, treatment response, and postsurgical distinction of recurrence [11,12,13].
For the assessment of a soft tissue tumor, T1-weighted sequences, fluid-sensitive sequences, and contrast-enhanced sequences are important to identify the extent of a mass. The use of contrast is particularly important when trying to differentiate between tumor extension and reactive inflammation, as edema does not typically enhance on postcontrast sequences [14]; this distinction can be further confirmed with DWI [15]. Similar to bone tumor assessment, tumor character and histology can be assessed with conventional anatomic sequences (T1-weighted, T2-weighted, and postcontrast T1-weighted features); as a general rule, malignant lesions are larger and more heterogeneous. The histology of certain tumors can also be suggested sometimes by some conventional features, such as lipid content in lipomatous masses; flow voids and time-sensitive contrast enhancement in vascular malformations; the target sign in peripheral nerve sheath tumors (Fig. 6); the triple sign in synovial sarcoma (T2-weighted images showing three different signal patterns—areas that are hypointense, isointense, and hyperintense within the lesion—related to necrosis, cystic degeneration, dystrophic calcifications, and fibrotic regions); the low-signal internal bands of desmoid tumor; and the tail sign that can be characteristic of a desmoid tumor, nodular fasciitis, and such malignancies as myxofibrosarcoma (Fig. 7) and undifferentiated pleomorphic sarcoma [16]. When tumors lack convincing classic signal characteristics on conventional anatomic imaging, functional techniques can be helpful for further characterization as malignancies typically exhibit restrictive diffusion by quantitative DWI and early enhancement by DCE MRI (Fig. 8) [17, 18].
Ultrasound
Ultrasonography is less commonly used in the initial assessment of a soft tissue mass, largely due to surgeons’ lack of familiarity in interpreting the images. It can be helpful to confirm the presence of tumor, determine the tumor’s relationships to surrounding structures, estimate dimensions, characterize internal contents of the lesion, and describe margins [19]. Surgeons also find it helpful in differentiating superficial cystic from solid masses (Fig. 9). Additionally, ultrasound is useful in evaluating soft tissue masses in young children who would otherwise require anesthesia for MRI. Positive findings on ultrasound should be correlated with additional advanced imaging as ultrasound is rarely sufficient on its own.
Computed tomography
Due to the superior contrast resolution of MRI, CT is not routinely used in evaluating suspected sarcomas [20]. However, CT can be helpful in certain clinical scenarios. For osseous lesions, it can provide details on tumor matrix, occult matrix mineralization, intra-articular extension, cortical involvement, and degree/depth of endosteal scalloping (Fig. 10) [21]. Surgeons often prefer CT for the evaluation of pelvic tumors because of their familiarity with interpreting anatomic relationships using this modality and because CT provides greater clarity than MRI owing to its higher spatial resolution and lower susceptibility to motion artifacts.
Biopsy
To establish a definitive diagnosis, a biopsy of the lesion typically must be obtained in order to perform tissue analysis. The diagnostic imaging work-up should be completed prior to biopsy, as it will not only guide the location of the biopsy to the most active portion of the lesion but also can provide additional context to the reviewing pathologist. Additionally, the biopsy tract may make it difficult to evaluate the extent of the lesion due to edema and reactive changes from the biopsy itself. While open biopsy is considered the gold standard, advances in pathologists’ ability to perform elaborate analysis on small amounts of tissue have shifted the biopsy paradigm to percutaneous needle biopsy. In the current era, image-guided percutaneous fine needle aspiration and core needle biopsy are most commonly utilized. Core needle biopsy is the preferred technique for image-guided biopsies of suspected sarcomas (Fig. 9). Many studies have reported on the diagnostic accuracy of core needle biopsy, highlighted by a recent meta-analysis showing that core needle biopsy is similarly accurate, while resulting in fewer complications, than incisional biopsy [22].
The primary modes of image guidance are CT and ultrasound. Ultrasound is ideally used to assess superficial soft tissue lesions, although lesions deep to the fascia can also be accurately sampled using ultrasound guidance [23]. Doppler ultrasound can improve sampling by identifying vascular regions in the tumor, which are likely to contain active cells, and avoid areas of necrosis [24]. Newer techniques, such as contrast-enhanced ultrasound [25] or CT/MRI-fusion ultrasound [26], also can improve visualization of the tumor and minimize sampling error by identifying viable portions of the tumor for biopsy. For deep or intraosseous lesions, CT guidance provides superior resolution [27].
Regardless of the image guidance used, there are multiple considerations in choosing the path for biopsying a lesion, and the shortest route to the tumor is not necessarily the best option [28]. Ideally, the biopsy should be oriented along the limb salvage incision. Errors in biopsy placement lead to more invasive procedures and worse patient outcomes at the time of final surgical resection [29]. Historically, biopsy tracts were resected as part of the definitive resection, although the recent literature has questioned the necessity of this approach [30]. The importance of communication between the surgical and radiology teams regarding the biopsy trajectory cannot be overemphasized.
Staging
Once a sarcoma diagnosis has been established, the next step is disease staging. There are a variety of different staging systems for sarcomas, all of which incorporate some combination of tumor size, tumor grade, local/nodal spread, and distant metastasis. Tumor size is evaluated on the initial diagnostic images, and grade is typically determined by biopsy, although studies have shown that both PET-CT [31] and MRI [32] may provide metrics to help predict the grade of a sarcoma. While staging studies can be completed before biopsy, having a working diagnosis from the biopsy may help guide the choice of staging studies and prevent the patient from undergoing unnecessary or incomplete initial studies. Additionally, some studies (particularly PET-CT) may not be approved by insurance prior to a formal cancer diagnosis.
Evaluations of the extent of disease focus on the most common sites of metastatic spread. For bone and soft tissue tumors, the lung is the most common site of metastatic disease. CT of the chest without contrast is the study of choice, as the addition of contrast does not improve diagnostic accuracy [33]. Multiple studies have shown that while PET-CT can identify larger pulmonary metastatic lesions, it performs worse than CT in evaluating pulmonary disease, particularly for nodules less than 1 cm (Fig. 11) [34]. While CT of the chest is the most sensitive modality for evaluating patients for pulmonary metastasis, rates of false-positive findings remain high due to the prevalence of benign and transient lung nodules, and in indeterminate cases expert consultation and serial exams are often necessary to make a final diagnosis of pulmonary metastasis [35].
Bone sarcomas also have a predilection for metastasizing to other osseous sites. Historically, such metastases have been evaluated using bone scintigraphy, in which Tc-99 methylene diphosphonate is used to identify sites of osteoblastic activity (a surrogate for metastatic lesions). This modality lacks specificity, as other bone-altering pathologies, such as osteoarthritis, fracture, and osteomyelitis, also are identified on bone scan. This led to interest in using more specific modalities to assess patients for distant metastases. Multiple investigations have evaluated PET-CT and found it to be superior to bone scintigraphy for identifying bony metastasis [36, 37]. When available, whole-body MRI, especially in combination with whole-body DWI, has the benefit of detecting both bone and soft tissue metastatic disease without exposing patients to radiation [38, 39].
Certain soft tissue sarcomas—specifically, angiosarcoma, epithelioid sarcoma, clear cell sarcoma, and rhabdomyosarcoma—have a propensity to metastasize to the lymph nodes, and thus require nodal assessment [40]. PET-CT has been used to assess for nodal involvement but does not have a high positive predictive value for nodal metastasis [41] and did not perform as well as sentinel lymph node biopsy in a study of adolescents and young adults with high-grade soft tissue sarcomas [42]. While PET-CT is currently the best imaging modality we have to evaluate for lymph node metastasis, this remains an area that requires further study. Newer imaging methodologies, like whole-body MRI, DWI MRI, and PET/MRI [43], increasingly have a role in better identifying pathologic nodal involvement and in the staging of sarcoma patients in general, when available.
CT of the chest, abdomen, and pelvis (CT CAP) is not routinely used in the staging of sarcomas but may be of use with certain histologies. The most common soft tissue sarcomas of the extremities that metastasize to the abdomen and retroperitoneum are myxoid liposarcoma, leiomyosarcoma, epithelioid sarcoma, myxofibrosarcoma, angiosarcoma, synovial sarcoma, and malignant peripheral nerve sheath tumor, and CT CAP may be considered for these histologies [44]. The use of CT CAP in the staging of sarcoma is an evolving field, and further data are required to identify the proper indications for its use in sarcoma staging.
Preoperative considerations
Treatment response
Once a patient has undergone appropriate diagnostic imaging, treatment commences, which typically involves some combination of surgery, chemotherapy, and radiation. Decisions regarding the types of treatment and their order are typically made in the setting of multidisciplinary tumor boards. For patients undergoing preoperative chemotherapy and/or radiation, repeat local imaging close to the date of surgery is critical, as response to treatment impacts the surgical plan. The imaging modalities most commonly used to assess treatment response are MRI and PET-CT, although the exact parameters to accurately assess treatment response are poorly defined. Moreover, not all changes seen on imaging correlate with a good histologic response; at least a 90% (bone tumors) or 95% (soft tissue tumors) histologic response is necessary for a good outcome [45,46,47]. Although the RECIST criteria are commonly used to measure progression/response to treatment in other solid tumors, they do not correlate well with histologic treatment response in sarcoma patients [48]. This is due primarily to the RECIST criteria’s reliance on tumor size to assess treatment response; even when a sarcoma has a strong histologic response to treatment (i.e., a high rate of tumor necrosis), the lesion does not always shrink due to the underlying collagenous or bony matrix, and in some cases may even increase in volume due to hemorrhage, necrosis, and edema [49]. In light of this, other modalities for assessing therapeutic response have been investigated, particularly functional MRI sequences and PET-CT. In a comparison of two methods for assessing radiologic response, Stacchiotti et al. found that the modified Choi criteria (which incorporate both size and internal enhancement patterns/characteristics on post-treatment MRI) were superior to the RECIST criteria for predicting survival [48]. Functional MRI sequences, such as DCE MRI and DWI MRI, have also been shown to accurately predict histological response [50], and to do better than RECIST criteria [51]; in particular, sarcomas that respond with tumor sclerosis rather than necrosis are best assessed with functional MRI sequences [45]. PET-CT studies have consistently shown that changes in standard uptake values on post-treatment PET-CT scans correlate with histologic response in both soft tissue sarcoma [52] and bone sarcoma [53]. New response criteria (named PERCIST) that incorporate PET-CT data are superior to the RECIST criteria in predicting local control and distant progression in soft tissue sarcoma.
In addition to MRI and PET-CT, newer imaging techniques and technologies for assessing response to treatment are being investigated. Techniques such as MR elastography [54] and combined PET/MRI [55] have shown promise in evaluating treatment response. The rapidly evolving field of radiomics (in which artificial intelligence, neural networks, and machine learning are used to analyze raw imaging data to produce clinically relevant information) has also shown promise in assessing treatment response [56, 57].
Radiation effects
The purpose of radiation is to reduce local recurrence of the tumor by treating satellite lesions in and beyond the pseudocapsule of the tumor that the imaging and surgeon cannot see. Decisions regarding the timing of radiation (preoperative, intraoperative, or postoperative) are complex and beyond the scope of this review. Some surgeons prefer preoperative radiation to facilitate a margin-negative surgery. However, the changes that occur in the tumor and surrounding tissues following preoperative radiation can make interpreting post-treatment MRI challenging. Specifically, post-radiation scarring and fibrosis can be difficult to differentiate from tumor or edema. DCE MRI and other functional MRI sequences can aid in distinguishing between the two [16]. Additional considerations when imaging a patient after radiation include allowing at least 3–4 weeks for the effects of treatment to be apparent and recognizing that new enhancement on postradiation images may indicate vascular disruption or hemorrhage rather than disease progression [58]. With conventional 2D MRI sequences, it is important to acquire images in the same plane and with the same imaging parameters as the pre-radiation study of the tumor to facilitate comparison; however, with the advent of 3D volumetric sequences, this issue is mitigated, and the original acquisition plane can be reconstructed into any plane of choice for optimal comparison of the pre- and postradiation studies.
Preoperative planning
Post-treatment imaging not only provides insight on the tumor’s response to the neoadjuvant treatment, but also serves a critical role in preoperative planning for the surgical team. The goal of surgery is to perform a wide excision, meaning that the tumor is taken out en bloc with a cuff of normal tissue and a negative microscopic margin. MRI is commonly used to assess involvement of key anatomical structures, determine the surgical approach, and form a reconstruction plan. When planning level of resection in bone sarcomas, surgeons should keep in mind that in a comparison of MRI pulse sequences (T1- vs. T2-weighted) and timing (before or after neoadjuvant chemotherapy), post-treatment T1 sequences had the strongest correlation with the resected specimen on final pathology review [59].
For soft tissue sarcomas, MRI also provides key information for planning margins. One particularly challenging scenario is the resection of myxofibrosarcoma and undifferentiated pleomorphic sarcoma, which may demonstrate an infiltrative growth pattern (Fig. 7), frequently identified as “tails” extending along fascial planes on MRI [60]. If this is not identified preoperatively, surgery may leave positive margins, which are associated with high rates of local recurrence [61]. DWI MRI [15] and contrast-enhanced, fat-suppressed images [62] aid in identifying the extent of these tails and may provide useful information in the planning of these cases. Even when resecting all concerning tissue identified on MRI, surgeons may have difficulty obtaining a negative margin on the first attempt, and some consider approaching these cases in a staged fashion, waiting for final pathology margin results prior to reconstruction and closure.
Intraoperative imaging
Imaging plays a key role in the operating room during resection of sarcomas. Intraoperative fluoroscopy is routinely used during the resection of bone sarcomas to help identify levels of resection determined during preoperative planning, and to aid in performing the reconstructive part of the procedure. Some institutions also have begun using intraoperative ultrasound to aid in resecting ill-defined or infiltrative soft tissue lesions [63].
One rapidly developing area in sarcoma surgery is the use of image-guided surgical navigation. Its use is particularly beneficial in procedures involving the pelvis and sacrum, which present the surgeon with anatomic challenges related to spatial orientation and the proximity of critical structures. Historically, rates of positive-margin resection and local recurrence have been higher for sarcomas in these locations than for extremity sarcomas, but intraoperative navigation is a promising method of reducing rates of these events [64]. Navigation may also assist in treating periarticular sarcomas in young patients by facilitating the performance of physeal- or articular-sparing wide resection, thus avoiding the need for arthroplasty [65].
Specific workflow may vary based on surgeon preference and institutional resources. Often, patients will undergo a CT scan in the operating room after placement of a fixed reference array. A computer will register these images with spatial orientation information provided by the array. The surgeon may then use a calibrated probe or other instrument with accompanying real-time visualization of orientation in axial, coronal, sagittal, and in-line-with-the-instrument planes. For bone sarcomas with large soft-tissue components, preoperative MRI may be reliably fused to the CT, allowing resections of lesions that are otherwise occult on CT (Fig. 12). Future developments in image-guided navigation may be characterized by increasing use of MRI-based referencing, as well as the introduction of augmented and mixed reality [66].
Surveillance
Patients with bone and soft tissue sarcomas are at risk for both local recurrence and distant metastases, which negatively impact overall survival [67]. The frequency of disease recurrence is risk-stratified by stage. Strong evidence is lacking regarding the method and time-frame for surveillance imaging of sarcoma patients. The National Comprehensive Cancer Network provides general guidelines for surveillance of high-grade soft tissue sarcoma and recommends imaging of the primary site and chest every 2–6 months for 2–3 years, every 6 months for the next 2 years, and annually thereafter [68]. There is no consensus for how long surveillance should continue, though metastasis and local recurrence beyond 10 years is uncommon for most sarcoma subtypes [69].
Local recurrence
Many factors contribute to local recurrence, including the size, location/depth, and histology of the tumor and whether surgery produced negative margins. Long-term prognosis after local recurrence is poor but repeat resection prior to the development of metastases may improve patient survival [70], highlighting the importance of detecting these events.
MRI with and without contrast is commonly performed for surveillance imaging of the primary disease site [4]. Advanced MRI sequences, such as DCE and DWI MRI, can improve detection rate and can help differentiate tumor from postoperative scarring and hematoma [16, 71]. Certain treatment factors may increase the difficulty of identifying local recurrence on MRI imaging. The use of metal implants can create signal artifact in the surgical field, an issue that may be circumvented by utilization of metal artifact–reducing MRI sequences (Fig. 13) (especially in combination with DCE MRI [72]) or PET-CT [73]. Additionally, certain motorized or expandable implants are not MRI-compatible and require evaluation with other imaging modalities. Soft-tissue defects may be reconstructed with myocutaneous flaps, which both alter the local anatomy and may have mass-like signal alterations; identifying this from the patient records can be helpful in distinguishing recurrence from normal postoperative anatomy (Figs. 14 and 15) [74]. Additionally, post-radiation changes such as radiation osteitis can be challenging to differentiate from malignancy in the bone marrow [75].
Other imaging modalities are also routinely used to assess for local recurrence. In some types of surgery, radiography is used to evaluate hardware (Fig. 14) and may be helpful in identifying new bony lesions as well. For soft tissue tumors, ultrasound may be effective as an initial screening test due to its high accuracy and negative predictive value; one study even found ultrasound to be equivalent to MRI for detecting local recurrence [76]. Ultrasound may also be used when visualization is limited by metal artifact. While imaging plays a key role in identifying local recurrence, a large portion of local recurrences are identified on physical exam or by the patients themselves [77], so patients should be counseled to notify the clinician of any changes they notice between surveillance visits.
Distant metastasis
As is the case for local recurrence, there is a paucity of high-powered studies to provide strong recommendations regarding the type and interval of chest screening. The two main modalities for such screening are chest radiography and CT. While CT is the most sensitive modality to assess lung nodules, this added sensitivity has not consistently correlated with better patient survival when compared to chest radiography, and additionally it increases the cost and radiation exposure to the patient [35]. Other modalities, such as PET-CT, have also been investigated, but PET-CT alone may not be able to detect small (< 1 cm) malignant nodules and therefore is not the current standard of care [34]. Surveillance of non-pulmonary sites at risk for metastases is driven by the histologic diagnosis (Fig. 16).
The TOSS randomized controlled trial attempted to compare survival outcomes between chest radiography and chest CT, and between 3-month versus 6-month follow-up, in patients who had undergone surgery for sarcoma of an extremity. The researchers found the less intensive follow-up method (chest radiography every 6 months) to be non-inferior to CT or to more frequent follow-up [77]. In contrast, another study found that rates of second complete remission and overall survival were higher for CT than for chest radiography among patients with osteosarcoma [78]. Since there is no consensus regarding the optimal modality and timing of chest screening, future studies should consider the role of patient-specific factors, such as histology type and grade, tumor size and location, and whether the patient would be a candidate for metastasectomy. Stratifying patients’ risk on the basis of these and other factors will likely prove more fruitful than attempting to prove the superiority of a single overarching surveillance protocol.
Conclusions
Over the past 5 decades, surgical care for sarcoma has benefited from the tremendous advances in radiology capabilities and techniques. Even in the past decade, many of the classic imaging paradigms in the management of bone and soft tissue sarcoma have begun to shift. Particularly, PET-CT and functional MRI scans have become more readily available and are being used to provide additional insights into a patient’s diagnosis, prognosis, and treatment response. As these technologies, and newer fields such as radiomics, continue to mature, this new data hopefully will provide us with more accurate diagnoses, a better ability to assess response to therapies, and nimbleness to alter treatment plans to better serve the individual patient’s needs. Furthermore, soft tissue sarcomas are commonly treated and studied as a single disease, while in reality the term “soft tissue sarcoma” encompasses over 100 different tumor histologies. As more data is collected on each individual sarcoma diagnosis, we will be able to move from generalized imaging protocols to specific protocols based on diagnostic risk stratification. More than ever, collaborative multi-institutional and registry-based efforts to reach the data thresholds required to make such improvements are needed.
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This work was funded in part through the NIH/NCI Cancer Center Support Grant P30 CA008748.
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Key points
• The initial imaging work-up of a suspected sarcoma includes extremity radiographs, MRI of the entire compartment, and chest CT to evaluate for pulmonary metastases. For bone sarcomas, the work-up also incorporates PET-CT or bone scintigraphy to evaluate other bones.
• Post-treatment surveillance evaluates the primary site, lung, and disease-specific areas at risk for metastases at regularly scheduled intervals.
• Advances in such imaging technologies as PET-CT, functional MRI, and radiomics are improving our ability to diagnose, stage, treat, and surveil patients with sarcoma.
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Kantzos, A.J., Fayad, L.M., Abiad, J.E. et al. The role of imaging in extremity sarcoma surgery. Skeletal Radiol 53, 1937–1953 (2024). https://doi.org/10.1007/s00256-024-04586-7
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DOI: https://doi.org/10.1007/s00256-024-04586-7