Abstract
The diagnosis of prosthetic joint infection (PJI) remains challenging, despite multiple available laboratory tests for both serum and synovial fluid analysis. The clinical symptoms of PJI are not always characteristic, particularly in the chronic phase, and there is often significant overlap in symptoms with non-infectious forms of arthroplasty failure. Further exacerbating this challenge is lack of a universally accepted definition for PJI, with publications from multiple professional societies citing different diagnostic criteria. While not included in many of the major societies’ guidelines for diagnosis of PJI, diagnostic imaging can play an important role in the workup of suspected PJI. In this article, we will review an approach to diagnostic imaging modalities (radiography, ultrasound, CT, MRI) in the workup of suspected PJI, with special attention to the limitations and benefits of each modality. We will also discuss the role that image-guided interventions play in the workup of these patients, through ultrasound and fluoroscopically guided joint aspirations. While there is no standard imaging algorithm that can universally applied to all patients with suspected PJI, we will discuss a general approach to diagnostic imaging and image-guided intervention in this clinical scenario.
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Introduction
Over 1 million prosthetic joint surgeries are performed annually in the USA, most commonly hip and knee joint replacements [1]. As the population ages, along with increasing rates of osteoarthritis, the frequency of these procedures is expected to increase, with an estimated 1.4 million annual hip arthroplasties and 1.4 million annual knee arthroplasties expected by 2040 [2]. Although often successful procedures, joint replacement can be complicated by prosthetic joint infection (PJI) in either the acute or chronic phase, with reported prevalence of 1.63% and 1.55% at 2 years for hip and knee replacements, respectively [3]. Given the implications of a PJI, a timely and accurate diagnosis is paramount to appropriate patient management and prevention of long-term morbidity.
The diagnosis of PJI remains challenging despite the availability of a variety of clinical signs, serum and synovial fluid markers, and microbiological and histological findings. While PJI can be readily diagnosed in the presence of a draining sinus or exposed implant [4], differentiating between septic and aseptic implant failure becomes much more challenging in the presence of nonspecific clinical symptoms and laboratory tests. Further adding to this complexity, there is lack of a universally accepted definition of PJI, which is reflected by the existence of at least six different definitions by reputable independent societies: the Musculoskeletal Infection Society (MSIS), the Infectious Disease Society of America (IDSA), two International Consensus Meetings, the European Bone and Joint Infection Society (EBJIS), and the World Association against Infection in Orthopedics and Trauma (WAIOT) [4,5,6,7,8,9,10]. For example, the MSIS evidence–based diagnostic tool defines PJI using major and minor diagnostic criteria [4]. The presence of one major criterion (two positive cultures of the same organism, or a sinus tract extending from the skin surface to the prosthetic joint) or multiple minor criteria are diagnostic of PJI under this scoring-based definition (Table 1). With the exception of the WAIOT definition, which includes radio-labeled leukocyte scintigraphy as a criterion, all other proposed diagnostic algorithms for PJI rely solely on laboratory tests and clinical features, without a clearly defined role for diagnostic imaging. None of the societies provides a scientific explanation for this exclusion, despite the reported value and frequent clinical utilization of diagnostic imaging in the workup of PJI [5]. One potential explanation for the lack of guidelines for utilization of imaging could be relative paucity of consolidated scientific evidence regarding the additional value of imaging in diagnosis of PJI. A few recent consensus statements have proposed diagnostic algorithms which utilize diagnostic imaging; however, evidence for many recommendations remains at the level of expert consensus, given the lack of robust studies directly comparing different imaging modalities in the workup of PJI [11, 12].
In this article, we will review an approach to diagnostic imaging in the setting of suspected PJI. We will review the benefits and limitations of the various imaging modalities employed to evaluate prosthetic joints and special technical considerations needed to maximize their diagnostic benefit. Additionally, we will discuss the role and available techniques for image-guided prosthetic joint aspiration. The utilization of nuclear medicine studies in the evaluation of PJI is beyond the scope of this article and will be addressed in a separate article in this issue.
Radiography
In the setting of clinically suspected PJI, radiography is the recommended first-line imaging study [13]. Radiographs provide a broad overview of the prosthetic joint and can exclude other potential causes of a painful prosthesis. Radiographs can delineate position of the arthroplasty components, periprosthetic fractures, or periprosthetic osteolysis. However, in the early stages of infection, radiographic appearance of the arthroplasty can be normal, as destruction of 30–60% of the bony trabeculae is required to produce radiographically evident osteolysis [14, 15]. Detection of periprosthetic osteolysis can also be location dependent, and radiographs can underestimate the presence and extent of periprosthetic osteolysis (Fig. 1) [16, 17]. As infection progresses, irregular radiolucency and osseous resorption at the prosthesis-bone or cement-bone interfaces can be seen, as well as lamellated periosteal reaction [17, 18]. If periprosthetic osseous destruction continues to progress, arthroplasty components can become loose and displace from their original position, and the adjacent bone or cement can fracture [19]. However, this appearance is not specific for infection, as aseptic osteolysis due to polyethylene particle disease or other forms of adverse local tissue reaction can appear similar. Comparison with prior imaging, if available, can be helpful in differentiating between septic and aseptic loosening, as more rapid progression of osteolysis is indicative of infection [14].
Evaluation of the periprosthetic soft tissues is limited on radiographs, and helpful indicators such as communicating soft tissue collections are often radiographically occult. When in large enough quantities, however, soft tissue gas is radiographically apparent. Soft tissue gas adjacent to an arthroplasty is an expected finding in the immediate post-operative period, but its presence beyond 14 days can suggest the presence of a PJI [20].
In our clinical practice, initial radiographs are often normal or demonstrate nonspecific findings, but are an important initial step in the imaging workup of PJI. In the setting of low clinical suspicion for PJI and normal laboratory workup, an initially normal radiograph may not warrant further imaging. In the presence of high clinical suspicion or radiographic findings suggestive of infection, image-guided aspiration should be pursued to confirm the diagnosis [21]. In cases of radiographically evident osteolysis and loosening with low clinical suspicion for PJI, we either pursue more advanced imaging or an image-guided joint aspiration to clarify the diagnosis.
Ultrasound
Compared with radiography, ultrasound plays a more limited role in the workup of PJI. The ultrasound beam cannot penetrate beyond the metallic arthroplasty components, limiting its assessment to the soft tissues superficial to a prosthetic joint. Although ultrasound is frequently indicated in evaluation for joint effusions and synovitis in native joints, there is less consensus on the utility of ultrasound to evaluate prosthetic joints [22]. Ultrasound can be utilized to assess for hypoechoic distention of a prosthetic joint, which may reflect an underlying effusion, synovial thickening, or a combination of the two (Fig. 2) [23, 24]. In more superficial prosthetic joints (such as the knee), compression can help distinguish between non-compressible synovial thickening and compressible joint effusion; however, this can be more difficult to assess in deeper joints such as the hip. In an attempt to utilize ultrasound to diagnose infected prostheses, van Holsbeeck and colleagues found a significant difference in anterior recess distention between infected and non-infected hip arthroplasties and concluded that anterior recess distention of less than 3.2 mm could be used to exclude the presence of a joint effusion and infection [19]. Weybright and colleagues later contradicted these findings and found no significant difference in anterior recess distention in patients with and without hip joint effusions, when using arthrocentesis as a gold standard [25].
The presence of extra-articular fluid collections or a sinus tract extending to the skin surface can also be detected on ultrasound, and while strongly suggestive of infection, these findings are not always present in the setting of PJI [26]. To the best of the authors’ knowledge, the value of ultrasound in assessing periprosthetic muscle edema and vascularity in the context of PJI has never been studied. As such, in evaluation of a suspected PJI, the American College of Radiology concluded that diagnostic ultrasound “may be appropriate” in the hip, but was “usually not appropriate” in the knee [13, 21]. Given the accessibility of CT and MRI in many clinical settings and superior soft tissue characterization afforded by these modalities compared with ultrasound, the utility of ultrasound for purely diagnostic purposes is limited. Ultrasound plays a more substantial role in the setting of ultrasound-guided prosthetic joint aspirations, which will be discussed in a subsequent section.
Computed tomography
Imaging with computed tomography (CT) can be beneficial in the workup of PJI, as it can delineate areas of periprosthetic osteolysis, and its superior soft tissue contrast compared with radiography can aid in the detection of periarticular soft tissue abnormalities. Similar to radiography, CT evaluation of an infected arthroplasty may initially be normal. The normal CT appearance of an arthroplasty will demonstrate solid osseous fixation of the prosthetic components, with less than 2-mm thin linear lucency visible at the prosthesis-bone or cement-bone interfaces. When osseous abnormalities are evident on CT, they can include focal or non-focal osteolysis (osseous resorption measuring more than 2 mm in thickness) at the prosthesis-bone or cement-bone interfaces, periosteal reaction, and loosening of the arthroplasty components [18, 27]. Compared with radiography, CT is more sensitive in the detection of osteolysis, allowing for superior characterization of the extent of osteolysis, as well as improved detection of small osteolytic lesions (Fig. 1) [16, 28].
Soft tissue CT findings in the setting of PJI include fluid/soft tissue distention of the prosthetic joint, fluid accumulation within the adjacent bursae, and periarticular soft tissue collections [17]. In an effort to distinguish CT findings specific for septic (rather than aseptic) osteolysis, Cyteval et al. found that both periostitis and intramuscular/peri-muscular fluid collections were highly specific for infection, but lacked sensitivity [17]. Isern et al. found that periprosthetic soft tissue extension beyond the joint capsule, osteolysis, and regional lymphadenopathy was predictive of PJI [29]. If clinically appropriate, the administration of intravenous contrast can also be used to better delineate the presence and extent of periarticular soft tissue collections, as well as sinus tract formation [30].
Despite the superior characterization of an arthroplasty with CT compared to radiography, CT is infrequently used in the initial workup for suspected PJI at the authors’ institution. MRI is often considered a more appropriate follow-up examination after initial radiograph, due to high diagnostic performance in the setting of PJI and lack of ionizing radiation, which is reflected in recent consensus statements [11,12,13, 21]. CT does provide value in the setting of a planned arthroplasty revision (whether septic or aseptic), as characterization of the osteolysis and residual bone stock can aid the performing surgeon in preoperative planning.
Technical considerations
When evaluating a suspected PJI with CT, metal-associated artifacts can limit the diagnostic value of CT, the severity of which can vary depending on the type, size, and shape of the implant. Beam hardening artifact and photon starvation substantially contribute to CT metal-associated artifacts generated by an arthroplasty, as well as photon scatter, edge effects, and patient motion to a lesser degree [31,32,33,34,35]. Metal-associated artifacts can not only hinder evaluation of the osseous structures immediately adjacent to the arthroplasty, but can also limit evaluation of the soft tissues somewhat distant from an arthroplasty (i.e., visceral pelvic anatomy in the setting of bilateral hip arthroplasty) [35].
Multiple parameters can be adjusted at the image acquisition and reconstruction phases to overcome metal-associated artifacts. Increasing the tube current (mAs) and tube voltage (kVp) will increase the number of photons that strike the detector, decreasing the effect of photon starvation and beam hardening artifacts, respectively. However, altering these parameters in isolation is often insufficient to produce a diagnostic quality image. Dual-energy CT, in which CT images are simultaneously acquired at both high and lower energy spectra, can be utilized to reconstruct a synthetic monoenergetic image with optimized kVp, minimizing the effect of beam hardening [31, 32, 35, 36]. In addition to modifications made at the acquisition phase, metal artifact reduction (MAR) techniques employ projection completion techniques to remove data corrupted by metal artifact at the reconstruction phase [31, 32, 36]. By identifying projections corrupted by metal, these corrupt projections can be subtracted from the original sinogram and filled in with interpolated data from adjacent detector elements. Each vendor has a proprietary metal artifact reduction sequence (MARS), some of which utilize MAR techniques and some of which combine dual-energy CT with MAR to further mitigate metal-associated artifact [34]. Deep learning–based reconstruction methods may also play a role in metal artifact suppression in the future [37].
However, there are pitfalls to the implementation of all metal-artifact reduction techniques. Increasing the mAs and kVp will increase the radiation dose to the patient [31]. Dual-energy CT can reduce beam hardening artifacts without increasing patient dose, but a high kVp technique will limit soft tissue contrast [32, 34, 35]. The use of MARS algorithms can also result in creation of new artifacts, as well as underestimation of the size of an arthroplasty (Fig. 3) [33, 34, 36]. Given these limitations of MARS, some authors have suggested that images reconstructed with MARS should be reviewed concurrently with non-MARS-reconstructed images to reduce diagnostic error [34].
Magnetic resonance imaging
Magnetic resonance imaging (MRI) allows for comprehensive evaluation of a prosthetic joint, with excellent contrast resolution to delineate the prosthesis-bone interface, as well as the adjacent soft tissues. In the setting of PJI, MRI can clearly demonstrate osteolysis, bone marrow edema pattern, and periosteal reaction [38]. While all MR sequences and imaging planes should be reviewed when evaluating an arthroplasty, some planes are more useful in delineating periprosthetic complications. For example, for hip arthroplasty, axial MR images are the most useful for evaluating the prosthesis-bone or cement-bone interfaces around the femoral and acetabular components. In our experience, bone resorption and osteolysis around the femoral component is best seen using axial proton density-weighted sequences, as circumferential thick (> 2 mm) layer of increased signal intensity at the prosthesis-bone interface, which can be surrounded by a layer of low signal intensity, likely reflecting granulation and fibrous tissue, and surrounding reactive osseous sclerosis (Fig. 4) [39]. Images should also be scrutinized for the integrity of the pseudocapsule, presence of synovitis, and distention of the periarticular bursae including popliteal, iliopsoas, subiliac, and trochanteric bursae (Fig. 5).
One of the most sensitive and specific MRI findings of infection is the presence of lamellated synovium, or thickened and hyperintense, multilayered synovium, first described by Plodkowski et al. in the context of knee arthroplasty (Fig. 4) [40]. This finding has been more recently shown by Gao et al. to have high sensitivity and specificity in the setting of hip arthroplasty as well [41]. Similarly, edematous synovitis has reported > 90% sensitivity and specificity for PJI in the setting of shoulder arthroplasty [42]. Additional MRI findings suggestive of PJI include the presence of a joint effusion, periosteal reaction, periprosthetic muscle/soft tissue edema or extracapsular collections, and regional lymphadenopathy (Fig. 6) [27, 38, 42,43,44,45]. The presence of bone marrow signal abnormalities involving both the femoral and acetabular component of a hip arthroplasty has been found more commonly in the setting of infection rather than aseptic loosening in some studies [38], while other studies did not show significant difference [44].
Although there is significant imaging overlap between infected and non-infected arthroplasties, there are a few imaging features that can help exclude the presence of PJI. In a cohort of patients with total shoulder arthroplasty, Fritz et al. found a 100% negative predictive value for infection in patients without a joint effusion, or without lymphadenopathy [42]. In their respective study cohorts, lack of lamellated synovitis had high negative predictive value for PJI in the hip and knee, and lack of edematous synovitis had a high negative predictive value for PJI in the shoulder [40,41,42].
The use of gadolinium-based intravenous contrast can provide additional diagnostic benefit in the setting of suspected infection. Contrast can help differentiate between thickened, enhancing synovium from simple joint effusion/intra-articular debris. Contrast-enhanced images can also better delineate sinus tracts and soft tissue collections, which may otherwise be difficult to perceive within a region of soft tissue edema [14]. Given the presence of a sinus tract extending from the skin surface to the prosthetic joint is a diagnostic criterion for PJI according to multiple societies [4, 6,7,8,9,10], diagnostic accuracy in detection of sinus tracts is crucial.
Technical considerations
Similar to CT, MR imaging for the detection of PJI requires certain technical considerations to minimize the impact of metal-associated artifacts, which will vary with implant material and orientation of the implant within the main magnetic field [36]. MR imaging of prosthetic joints is often performed on 1.5T scanners, rather than 3T, as the magnetic susceptibility artifact generated by an arthroplasty is proportional to the main magnetic field strength [46]. However, a recent study by Khodarami et al. demonstrated interchangeability of 1.5T and 3T MRI for diagnosis of periprosthetic abnormalities; more effective metal artifact reduction and superior bone-implant interface characterization was seen at 1.5T, but 3T images demonstrated lower noise, sharper edges, and better visibility of the periprosthetic tissues [47].
Fast spin echo sequences are the mainstay of arthroplasty MR imaging, as the refocusing pulse will minimize spin dephasing near the arthroplasty [36, 48]. A wider receiver bandwidth, smaller slice thickness, and orientation of the static magnetic field along the long axis of the arthroplasty will further minimize metallic susceptibility artifact [36, 46]. View angle tilting (VAT) can also be utilized to reduce in-plane artifacts by tilting the readout direction to account for in-plane misregistration around metal [36]. If fat-suppressed sequences are desired, sequences such as short tau inversion recovery (STIR) should be used for more homogeneous fat suppression, as frequency-selective fat suppression techniques are susceptible to failure around the arthroplasty (Fig. 7) [49].
Commercially available metal-artifact reduction techniques include section encoding for metal artifact correction (SEMAC), multi-acquisition variable-resonance image combination (MAVRIC), and the hybrid MAVRIC selective (MAVRIC-SL). SEMAC relies on an additional phase-encoding gradient to excite multiple spatial partitions, which are combined to form a composite image, as well as view angle tilting to reduce in-plane distortion [36]. MAVRIC relies on the acquisition of multiple frequency bins, which are combined to form a composite image [46]. The hybrid MAVRIC-SL excites multiple frequency bins similar to MAVRIC, but utilizes a Z-gradient to resolve through-plane aliasing similar to SEMAC [50]. An example of the hip arthroplasty MR imaging protocol from the authors’ institution, which utilizes SEMAC for metal-artifact reduction, can be found in Table 2.
There are disadvantages associated with each of the previously described modifications. A wider receiver bandwidth, for example, will result in decreased signal-to-noise ratio (SNR), which can be overcome by increasing the number of excitations, at the expense of total scan time [46, 51]. Acceleration techniques such as compressed sensing, with pseudo-random under-sampling of k-space, can be implemented, reducing SEMAC acquisition times by 60–70% [36, 49, 51]. Additionally, while STIR sequences can provide homogeneous periprosthetic fat suppression, they have lower SNR compared with frequency-selective fat suppression techniques and preclude the use of intravenous contrast as the signal of enhancing tissue will be nulled [46]. If post-contrast sequences are desired, non-fat suppressed post-contrast sequences can be subtracted from pre-contrast T1 sequences to evaluate for tissue enhancement [48].
Image-guided procedures
Percutaneous image-guided prosthetic joint aspirations are essential in the workup of suspected PJI. Synovial fluid markers are included in multiple different societies’ diagnostic criteria for PJI, as joint fluid analysis has higher diagnostic accuracy than serum analysis [4, 6,7,8, 52]. Preoperative prosthetic joint aspirations allow for laboratory analysis of synovial fluid, including leukocyte count, neutrophil percentage, leukocyte esterase, alpha-defensin, and c-reactive protein (CRP) [53]. Two recent meta-analyses concluded that alpha-defensin, an anti-microbial peptide secreted by neutrophils, has the highest diagnostic performance for PJI with a sensitivity of 97% and specificity of 96–97% [53,54,55]. Synovial fluid bacterial cultures can also be performed, and a recent meta-analysis found that preoperative synovial fluid cultures have a sensitivity of 68.6% and specificity of 96.4% [53]. Although the sensitivity of synovial culture is insufficient to definitively exclude PJI, obtaining preoperative synovial fluid samples percutaneously allows for appropriate selection of antibiotic therapy based on cultured sensitivities and selection of appropriate antibiotic laden cement for revision surgery [56, 57]. More recently, next-generation gene sequencing assays have been found to outperform culture in accurate detection of PJI, with reported sensitivity, specificity, and positive predictive value of 94.8%, 89.2%, and 93.2%, respectively, as well as a shorter reporting time of 1.3 days [58,59,60].
Although the diagnostic benefit of synovial fluid analysis in patients with high suspicion for PJI is well-documented, there is less consensus on the role of aspiration in equivocal cases. Some institutions will perform preoperative aspirations to exclude infection in all patients with planned arthroplasty revision, but this practice is not universal. The AAOS 2011 guidelines for diagnosis of PJI recommended aspiration for all patients with high clinical suspicion, as well as those with low clinical suspicion for PJI but with elevated erythrocyte sedimentation rate (ESR) or CRP [61]. Regardless of clinical concern, if both ESR and CRP were normal, aspiration was not recommended. In 2019, the International Consensus on Orthopedic Infections concluded that joint aspiration was an important initial step in the workup of PJI, with “no clearly identified contraindications” [62]. A recent study by Staphorst et al. concluded that patients undergoing revision surgery for mechanical failure with normal ESR/CRP probably do not need preoperative synovial analysis, but aspiration is justifiable in all patients with loosening [63].
While aspiration of a knee arthroplasty can be performed without imaging guidance using palpable bony landmarks, the use of ultrasound guidance allows the performing radiologist to target small pockets of fluid in joints where only trace effusions are present. In deeper joints such as the hip, a lack of palpable landmarks and proximity of regional neurovascular structures obligate the need for image guidance when performing joint aspirations. Hip aspirations are frequently performed with either fluoroscopic or ultrasound guidance (Fig. 8). With fluoroscopic guidance, the aspiration needle can be advanced into the intra-articular space, allowing for fluid aspiration and culture. Fluoroscopically guided aspirations of the hip joint can also serve a diagnostic purpose, as injection of iodinated contrast into the hip joint after aspiration can delineate communication from the hip joint to adjacent soft tissue collections or sinus tracts (Fig. 9). While communication with the adjacent greater trochanteric or iliopsoas bursae of the hip may be an expected post-surgical finding, communication of an irregular soft tissue collection with the prosthetic hip joint is more suggestive of infection [18]. With ultrasound guidance, the operator can directly target fluid within the prosthetic hip joint, as well as within adjacent soft tissue collections, if present. Perhaps owing to the ability to directly target loculated fluid within the joint, ultrasound-guided hip aspirations have reported to have higher sensitivity and specificity compared with fluoroscopically guided hip aspirations [64]. Less commonly, CT can be utilized for image-guided prosthetic joint aspirations; however, CT lacks the real-time guidance of ultrasound and has higher radiation dose than fluoroscopy [65, 66]. While this technique has been shown to be an accurate method of diagnosing PJI [29, 67], it is rarely utilized at the authors’ institution, except in cases were joint access is limited by overlying bony proliferative changes, or extreme cases of osteolysis with a displaced prosthesis. Ultimately, multiple factors including provider comfort, patient body habitus, and availability of equipment all play a role in which modality is appropriate for an image-guided prosthetic joint aspiration.
A “dry tap” can be encountered if there is insufficient aspirate from a prosthetic joint for laboratory analysis in the setting of suspected infection (typically less than 0.5 mL) [68]. Saline lavage, or injection of non-bacteriostatic sterile saline into the joint and subsequent re-aspiration, may be performed following a dry tap, although this technique remains controversial. Some studies have demonstrated that dilution of synovial fluid in saline decreases sensitivity of cell counts [69] or increases rates of intraoperative and preoperative culture discordance [68]. However, other studies have shown that neutrophil percentage and cultured organisms from lavage samples remain similar to native fluid aspiration [56, 70, 71]. The International Consensus on Orthopedic Infections (2019) recommended against saline lavage, with an exception made for aspirations performed by dedicated radiologists in a sterile manner [62]. In our clinical practice, we have found that surgeons’ preferences regarding lavage can vary depending on their pre-test probability for infection and consultation prior to aspiration is recommended. If small amounts of native fluid are obtained, cell count is often prioritized, given higher sensitivity and shorter reporting time compared with synovial culture. A recent study reviewing the outcomes of patients whose image-guided hip aspiration for suspected PJI resulted in a dry tap found that 84% of these patients were ultimately not diagnosed with PJI [71]. Among those who were diagnosed with PJI, greater than one third had dehiscence of the hip prosthesis pseudocapsule, with extra-articular extension of joint fluid into a dependent or posterior location, likely contributing to the dry tap. In these cases, pre-aspiration MRI or ultrasound could help delineate the presence of joint effusion or pseudocapsule dehiscence with extra-articular fluid collection and help to guide a targeted aspiration (Fig. 10) [71]. Finally, synovial biopsies can also be performed preoperatively, with multiple techniques described in the literature, ranging from fine needle aspiration to sampling with various biopsy devices [72,73,74,75]. Studies have shown that synovial biopsy can have diagnostic benefit when joint fluid is absent, but have no more diagnostic yield than synovial aspiration alone when joint fluid is present [72,73,74,75].
Conclusion
Diagnostic imaging can play an important role in the workup of PJI. Radiographs are a useful screening tool, but more advanced imaging or image-guided joint aspiration is usually required. MRI is the superior diagnostic imaging modality for characterizing the prosthetic joint and its surrounding bone and soft tissue, but requires modification of standard acquisition techniques to be clinically valuable. Image-guided joint aspirations remain crucial component in the workup of PJI, especially with advent of more efficient and accurate diagnostic tests such as next-generation gene sequencing. In the case of insufficient fluid for aspiration, further diagnostic imaging can identify extracapsular decompression of fluid that can be specifically targeted. Although dry taps are less likely to be associated with PJI, lack of fluid on aspiration, or even negative synovial fluid culture, should not be considered sufficient to definitively exclude PJI. With the emergence of more evidence-based diagnostic algorithms for imaging utilization in the workup of PJI, as well as technical advances in CT and MR image acquisition, diagnostic imaging and image-guided intervention can help guide clinical management of patients with suspected prosthetic joint infection.
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Key points
• Diagnostic imaging is frequently utilized in the workup of prosthetic joint infection (PJI), despite lack of clear consensus on the specific role of each modality.
• MRI is the optimal diagnostic modality for PJI, as it has high sensitivity and specificity for PJI when metal artifact reduction techniques are utilized.
• Image-guided prosthetic joint aspirations allow for synovial fluid analysis that is critical to diagnosing PJI, with newer synovial laboratory markers demonstrating higher diagnostic performance than culture.
• Although “dry” image-guided joint aspirations are more common in patients without PJI, dry taps in the setting of hip PJI are commonly due to dehiscence of the prosthesis pseudocapsule.
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Jardon, M., Fritz, J. & Samim, M. Imaging approach to prosthetic joint infection. Skeletal Radiol 53, 2023–2037 (2024). https://doi.org/10.1007/s00256-023-04546-7
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DOI: https://doi.org/10.1007/s00256-023-04546-7