Abstract
Lung cancer is a malignant disease causing the majority cancer mortality that progresses through several steps, involving dysfunction or dysregulation of many genes, genetic defect accumulation, and genome instability. Various mutations as well as defect in cellular signaling have been identified leading to the development of novel molecular targets for drug action. It is convincing that controlling of key signaling regulating hallmark of cancer may result in long-term benefit for cancer management. In terms of lung cancer, survival rate of patient was shown to drop dramatically when the disease spread, and the prognosis of the metastasis lung cancer is poor. Novel therapeutic approaches targeting on metastasis potentials and key proteins regulating aggressive are of interest. Among several new therapeutic compounds from natural sources, the marine-derived compounds were shown to have a promising value as several actives have been approved for anti-cancer approaches. Not only the complex unique structure of marine-derived agents has been shown to potently cytotoxic to cancer cells, but several compounds exhibited targeted effect on certain proteins.
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Chanvorachote, P., Hutamekalin, P., Chunhacha, P., Ei, Z.Z. (2022). Potential Natural Product Derived Compounds for Lung Cancer Therapy. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-1247-3_16-1
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