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Retinopathy of Prematurity

Neonatology

  • 321 Accesses

Abstract

Retinopathy of prematurity (ROP) is an ocular disorder that affects the integrity and function of the immature vasculature and neurons of the developing retina. ROP is considered the major cause of visual impairment and blindness in premature infants. This chapter includes a general review of the current knowledge about this disorder including demographic incidence, risk factors, recent observations regarding neurovascular dysfunctions in both the inner and outer immature retina, mechanisms and factors implicated in the pathophysiology of ROP. Finally, recommendations for surveillance and follow-up for ROP, as well as current and future preventive therapeutic strategies to preserve retinal structure and function are discussed.

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Acknowledgments

We thank Drs. Maria Ana Martinez, Daniel Moreno, and Hugo Quiroz of the Association to Prevent Blindness in Mexico (APEC) for the contribution of the pictures in Figs. 3 and 4.

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Authors and Affiliations

  1. Departments of Pediatrics, Ophthalmology and Pharmacology, Centre Hospitalier, Universitaire Sainte-Justine, Research Center, 3175, Chemin de la Côte-Sainte-Catherine, H3T 1C5, Montréal, QC, Canada

    José Carlos Rivera, Tianwei Ellen Zhou, Luis H. Ospina & Sylvain Chemtob

  2. Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Center, Montréal, QC, Canada

    José Carlos Rivera & Sylvain Chemtob

  3. INSERM UMRS1138, Centre de Recherche des Cordeliers, Paris, France

    Elsa Duchemin-Kermorvant

  4. Department of Ophthalmology/Neurology, McGill University-Montreal Children’s Hospital Research Institute, Montreal, QC, Canada

    Allison Dorfman

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  1. José Carlos Rivera
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  3. Allison Dorfman
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  4. Tianwei Ellen Zhou
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  6. Sylvain Chemtob
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Correspondence to Sylvain Chemtob .

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Editors and Affiliations

  1. Siena, Italy

    Giuseppe Buonocore

  2. Medicina della Riproduzione, Università di Siena Dipto. Pediatria, Ostetricia e, Siena, Italy

    Rodolfo Bracci

  3. Liverpool Women's Hospital Neonatal Unit, Liverpool, United Kingdom

    Michael Weindling

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Rivera, J.C., Duchemin-Kermorvant, E., Dorfman, A., Zhou, T.E., Ospina, L.H., Chemtob, S. (2016). Retinopathy of Prematurity. In: Buonocore, G., Bracci, R., Weindling, M. (eds) Neonatology. Springer, Cham. https://doi.org/10.1007/978-3-319-18159-2_283-1

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  • DOI: https://doi.org/10.1007/978-3-319-18159-2_283-1

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  1. Latest

    Retinopathy of Prematurity
    Published:
    08 February 2018

    DOI: https://doi.org/10.1007/978-3-319-18159-2_283-2

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    Retinopathy of Prematurity
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    07 April 2016

    DOI: https://doi.org/10.1007/978-3-319-18159-2_283-1

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