Abstract
Regulation of food intake is complex, with many peripheral and central inputs. The goal of these inputs is homeostatic maintenance of stable weight and optimal nutrient supplies. Homeostatic regulation includes central mechanisms in the hypothalamus and peripheral short- and long-term mechanisms, mediated mainly by gastrointestinal and adipose tissue peptides. Appetite and feeding regulating factors can be described as orexigenic (appetite and feeding-enhancing) or anorexigenic (appetite and feeding-reducing). Orexigenic factors involve peripheral ghrelin and the centrally acting NPY/AgRP system. Anorexigenic factors include gastrointestinal peptides, the adipose tissue hormone leptin, and the centrally acting melanocortin system. In addition to homeostatic regulation, hedonic and cognitive feedback neurocircuits influence feeding and appetite, and their dysfunction plays an essential role in the onset and maintenance of several psychiatric diseases, mainly eating disorders. In-depth knowledge of changes in brain connectivity and central and peripheral mechanisms of food intake regulation is crucial for understanding the pathogenesis of eating disorders, obesity, and comorbidities.
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Anik, A., Catli, G., Abaci, A., Kume, T., & Bober, E. (2014). Fasting and postprandial levels of a novel anorexigenic peptide nesfatin in childhood obesity. Journal of Pediatric Endocrinology & Metabolism, 27(7–8), 623–628. https://doi.org/10.1515/jpem-2013-0475
Awofala, A. A., Ogundele, O. E., Adekoya, K. O., & Osundina, S. A. (2019). Adiponectin and human eating behaviour: A Mendelian randomization study. Egyptian Journal of Medical Human Genetics, 20(1), 1–7.
Awofala, A. A., Ogundele, O. E., & Adekoya, K. O. (2020). ADIPOQ gene is linked to emotional eating behaviour in young Nigerian adults independent of psychological traits. Bulletin of the National Research Centre, 44(1), 1–7.
Bagger, J. I., Holst, J. J., Hartmann, B., Andersen, B., Knop, F. K., & Vilsboll, T. (2015). Effect of oxyntomodulin, glucagon, GLP-1, and combined glucagon +GLP-1 infusion on food intake, appetite, and resting energy expenditure. The Journal of Clinical Endocrinology and Metabolism, 100(12), 4541–4552. https://doi.org/10.1210/jc.2015-2335
Baggio, L. L., & Drucker, D. J. (2014). Glucagon-like peptide-1 receptors in the brain: Controlling food intake and body weight. The Journal of Clinical Investigation, 124(10), 4223–4226. https://doi.org/10.1172/JCI78371
Ballantyne, G. H. (2006). Peptide YY(1-36) and peptide YY(3-36): Part I. Distribution, release and actions. Obesity Surgery, 16(5), 651–658. https://doi.org/10.1381/096089206776944959
Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., … Bloom, S. R. (2002). Gut hormone PYY(3-36) physiologically inhibits food intake. Nature, 418(6898), 650–654. https://doi.org/10.1038/nature00887
Batterham, R. L., Le Roux, C. W., Cohen, M. A., Park, A. J., Ellis, S. M., Patterson, M., … Bloom, S. R. (2003). Pancreatic polypeptide reduces appetite and food intake in humans. The Journal of Clinical Endocrinology and Metabolism, 88(8), 3989–3992. https://doi.org/10.1210/jc.2003-030630
Becker, K. R., Mancuso, C., Dreier, M. J., Asanza, E., Breithaupt, L., Slattery, M., … Lawson, E. A. (2021). Ghrelin and PYY in low-weight females with avoidant/restrictive food intake disorder compared to anorexia nervosa and healthy controls. Psychoneuroendocrinology, 129, 105243. https://doi.org/10.1016/j.psyneuen.2021.105243
Bower, R. L., & Hay, D. L. (2016). Amylin structure-function relationships and receptor pharmacology: Implications for amylin mimetic drug development. British Journal of Pharmacology, 173(12), 1883–1898. https://doi.org/10.1111/bph.13496
Cnop, M., Havel, P. J., Utzschneider, K. M., Carr, D. B., Sinha, M. K., Boyko, E. J., … Kahn, S. E. (2003). Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: Evidence for independent roles of age and sex. Diabetologia, 46(4), 459–469. https://doi.org/10.1007/s00125-003-1074-z
Dostalova, I., Sedlackova, D., Papezova, H., Nedvidkova, J., & Haluzik, M. (2009). Serum visfatin levels in patients with anorexia nervosa and bulimia nervosa. Physiological Research, 58(6), 903–907. https://doi.org/10.33549/physiolres.931680
Druce, M. R., Neary, N. M., Small, C. J., Milton, J., Monteiro, M., Patterson, M., et al. (2006). Subcutaneous administration of ghrelin stimulates energy intake in healthy lean human volunteers. International Journal of Obesity, 30(2), 293–296. https://doi.org/10.1038/sj.ijo.0803158
Farr, O. M., Sofopoulos, M., Tsoukas, M. A., Dincer, F., Thakkar, B., Sahin-Efe, A., … Mantzoros, C. S. (2016). GLP-1 receptors exist in the parietal cortex, hypothalamus and medulla of human brains and the GLP-1 analogue liraglutide alters brain activity related to highly desirable food cues in individuals with diabetes: A crossover, randomised, placebo-controlled trial. Diabetologia, 59(5), 954–965. https://doi.org/10.1007/s00125-016-3874-y
Flak, J. N., & Myers, M. G., Jr. (2016). Minireview: CNS mechanisms of leptin action. Molecular Endocrinology, 30(1), 3–12. https://doi.org/10.1210/me.2015-1232
Fruhbeck, G. (2011). Gastrointestinal hormones: Uroguanylin-a new gut-derived weapon against obesity? Nature Reviews. Endocrinology, 8(1), 5–6. https://doi.org/10.1038/nrendo.2011.206
Gantz, I., Erondu, N., Mallick, M., Musser, B., Krishna, R., Tanaka, W. K., … Amatruda, J. M. (2007). Efficacy and safety of intranasal peptide YY3-36 for weight reduction in obese adults. The Journal of Clinical Endocrinology and Metabolism, 92(5), 1754–1757. https://doi.org/10.1210/jc.2006-1806
Ge, X. C., Yang, H., Bednarek, M. A., Galon-Tilleman, H., Chen, P. R., Chen, M., … Kaplan, D. D. (2018). LEAP2 is an endogenous antagonist of the ghrelin receptor. Cell Metabolism, 27(2), 461. https://doi.org/10.1016/j.cmet.2017.10.016
Hebebrand, J., Muller, T. D., Holtkamp, K., & Herpertz-Dahlmann, B. (2007). The role of leptin in anorexia nervosa: Clinical implications. Molecular Psychiatry, 12(1), 23–35. https://doi.org/10.1038/sj.mp.4001909
Heruc, G. A., Little, T. J., Kohn, M. R., Madden, S., Clarke, S. D., Horowitz, M., & Feinle-Bisset, C. (2018). Effects of starvation and short-term refeeding on gastric emptying and postprandial blood glucose regulation in adolescent girls with anorexia nervosa. American Journal of Physiology. Endocrinology and Metabolism, 315(4), E565–E573. https://doi.org/10.1152/ajpendo.00149.2018
Holtkamp, K., Hebebrand, J., Mika, C., Grzella, I., Heer, M., Heussen, N., & Herpertz-Dahlmann, B. (2003). The effect of therapeutically induced weight gain on plasma leptin levels in patients with anorexia nervosa. Journal of Psychiatric Research, 37(2), 165–169. https://doi.org/10.1016/s0022-3956(02)00100-0
Hopkins, D. F., & Williams, G. (1997). Insulin receptors are widely distributed in human brain and bind human and porcine insulin with equal affinity. Diabetic Medicine, 14(12), 1044–1050. https://doi.org/10.1002/(SICI)1096-9136(199712)14:12<1044::AID-DIA508>3.0.CO;2-F
Housova, J., Anderlova, K., Krizova, J., Haluzikova, D., Kremen, J., Kumstyrova, T., … Haluzik, M. (2005). Serum adiponectin and resistin concentrations in patients with restrictive and binge/purge form of anorexia nervosa and bulimia nervosa. The Journal of Clinical Endocrinology and Metabolism, 90(3), 1366–1370. https://doi.org/10.1210/jc.2004-1364
Howard, A. D., Feighner, S. D., Cully, D. F., Arena, J. P., Liberator, P. A., Rosenblum, C. I., … Van der Ploeg, L. H. (1996). A receptor in pituitary and hypothalamus that functions in growth hormone release. Science, 273(5277), 974–977. https://doi.org/10.1126/science.273.5277.974.
Hug, C., Wang, J., Ahmad, N. S., Bogan, J. S., Tsao, T. S., & Lodish, H. F. (2004). T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proceedings of the National Academy of Sciences of the United States of America, 101(28), 10308–10313. https://doi.org/10.1073/pnas.0403382101
Ilyas, A., Hubel, C., Stahl, D., Stadler, M., Ismail, K., Breen, G., et al. (2019). The metabolic underpinning of eating disorders: A systematic review and meta-analysis of insulin sensitivity. Molecular and Cellular Endocrinology, 497, 110307. https://doi.org/10.1016/j.mce.2018.10.005
Jones, J. M., Lawson, M. L., Daneman, D., Olmsted, M. P., & Rodin, G. (2000). Eating disorders in adolescent females with and without type 1 diabetes: Cross sectional study. BMJ, 320(7249), 1563–1566. https://www.ncbi.nlm.nih.gov/pubmed/10845962
Keel, P. K., Eckel, L. A., Hildebrandt, B. A., Haedt-Matt, A. A., Appelbaum, J., & Jimerson, D. C. (2018). Disturbance of gut satiety peptide in purging disorder. The International Journal of Eating Disorders, 51(1), 53–61. https://doi.org/10.1002/eat.22806
Keire, D. A., Mannon, P., Kobayashi, M., Walsh, J. H., Solomon, T. E., & Reeve, J. R., Jr. (2000). Primary structures of PYY, [Pro(34)]PYY, and PYY-(3-36) confer different conformations and receptor selectivity. American Journal of Physiology. Gastrointestinal and Liver Physiology, 279(1), G126–G131. https://doi.org/10.1152/ajpgi.2000.279.1.G126
Khanh, D. V., Choi, Y. H., Moh, S. H., Kinyua, A. W., & Kim, K. W. (2014). Leptin and insulin signaling in dopaminergic neurons: Relationship between energy balance and reward system. Frontiers in Psychology, 5, 846. https://doi.org/10.3389/fpsyg.2014.00846
Kieffer, T. J., & Habener, J. F. (2000). The adipoinsular axis: Effects of leptin on pancreatic beta-cells. American Journal of Physiology. Endocrinology and Metabolism, 278(1), E1–E14. https://doi.org/10.1152/ajpendo.2000.278.1.E1
Klok, M. D., Jakobsdottir, S., & Drent, M. L. (2007). The role of leptin and ghrelin in the regulation of food intake and body weight in humans: A review. Obesity Reviews, 8(1), 21–34. https://doi.org/10.1111/j.1467-789X.2006.00270.x
Kosinski, J. R., Hubert, J., Carrington, P. E., Chicchi, G. G., Mu, J., Miller, C., … Pocai, A. (2012). The glucagon receptor is involved in mediating the body weight-lowering effects of oxyntomodulin. Obesity (Silver Spring), 20(8), 1566–1571. https://doi.org/10.1038/oby.2012.67
Lieverse, R. J., Jansen, J. B., Masclee, A. M., & Lamers, C. B. (1994). Satiety effects of cholecystokinin in humans. Gastroenterology, 106(6), 1451–1454. https://doi.org/10.1016/0016-5085(94)90397-2
Lieverse, R. J., Jansen, J. B., Masclee, A. A., & Lamers, C. B. (1995). Satiety effects of a physiological dose of cholecystokinin in humans. Gut, 36(2), 176–179. https://doi.org/10.1136/gut.36.2.176
Mancuso, C., Izquierdo, A., Slattery, M., Becker, K. R., Plessow, F., Thomas, J. J., … Misra, M. (2020). Changes in appetite-regulating hormones following food intake are associated with changes in reported appetite and a measure of hedonic eating in girls and young women with anorexia nervosa. Psychoneuroendocrinology, 113, 104556. https://doi.org/10.1016/j.psyneuen.2019.104556
Mani, B. K., Puzziferri, N., He, Z., Rodriguez, J. A., Osborne-Lawrence, S., Metzger, N. P., et al. (2019). LEAP2 changes with body mass and food intake in humans and mice. The Journal of Clinical Investigation, 129(9), 3909–3923. https://doi.org/10.1172/JCI125332
McGowan, B. M., & Bloom, S. R. (2004). Peptide YY and appetite control. Current Opinion in Pharmacology, 4(6), 583–588. https://doi.org/10.1016/j.coph.2004.06.007
Merlino, D. J., Barton, J. R., Charsar, B. A., Byrne, M. D., Rappaport, J. A., Smeyne, R. J., … Waldman, S. A. (2019). Two distinct GUCY2C circuits with PMV (hypothalamic) and SN/VTA (midbrain) origin. Brain Structure & Function, 224(8), 2983–2999. https://doi.org/10.1007/s00429-019-01949-y
Meyer-Gerspach, A. C., Wolnerhanssen, B., Beglinger, B., Nessenius, F., Napitupulu, M., Schulte, F. H., … Beglinger, C. (2014). Gastric and intestinal satiation in obese and normal weight healthy people. Physiology & Behavior, 129, 265–271. https://doi.org/10.1016/j.physbeh.2014.02.043
Miao, J., Benomar, Y., Al Rifai, S., Poizat, G., Riffault, L., Crepin, D., & Taouis, M. (2018). Resistin inhibits neuronal autophagy through toll-like receptor 4. The Journal of Endocrinology, 238(1), 77–89. https://doi.org/10.1530/JOE-18-0096
Monteleone, P., & Maj, M. (2013). Dysfunctions of leptin, ghrelin, BDNF and endocannabinoids in eating disorders: Beyond the homeostatic control of food intake. Psychoneuroendocrinology, 38(3), 312–330. https://doi.org/10.1016/j.psyneuen.2012.10.021
Monteleone, P., Di Lieto, A., Tortorella, A., Longobardi, N., & Maj, M. (2000). Circulating leptin in patients with anorexia nervosa, bulimia nervosa or binge-eating disorder: Relationship to body weight, eating patterns, psychopathology and endocrine changes. Psychiatry Research, 94(2), 121–129. https://doi.org/10.1016/s0165-1781(00)00144-x
Monteleone, P., Fabrazzo, M., Tortorella, A., Fuschino, A., & Maj, M. (2002). Opposite modifications in circulating leptin and soluble leptin receptor across the eating disorder spectrum. Molecular Psychiatry, 7(6), 641–646. https://doi.org/10.1038/sj.mp.4001043
Monteleone, P., Fabrazzo, M., Martiadis, V., Fuschino, A., Serritella, C., Milici, N., & Maj, M. (2003). Opposite changes in circulating adiponectin in women with bulimia nervosa or binge eating disorder. The Journal of Clinical Endocrinology and Metabolism, 88(11), 5387–5391. https://doi.org/10.1210/jc.2003-030956
Monteleone, P., DiLieto, A., Castaldo, E., & Maj, M. (2004). Leptin functioning in eating disorders. CNS Spectrums, 9(7), 523–529. https://doi.org/10.1017/s1092852900009615
Muller, T. D., Nogueiras, R., Andermann, M. L., Andrews, Z. B., Anker, S. D., Argente, J., … Tschop, M. H. (2015). Ghrelin. Molecular Metabolism, 4(6), 437–460. https://doi.org/10.1016/j.molmet.2015.03.005
Naessen, S., Carlstrom, K., Holst, J. J., Hellstrom, P. M., & Hirschberg, A. L. (2011). Women with bulimia nervosa exhibit attenuated secretion of glucagon-like peptide 1, pancreatic polypeptide, and insulin in response to a meal. The American Journal of Clinical Nutrition, 94(4), 967–972. https://doi.org/10.3945/ajcn.111.014837
Palasz, A., Krzystanek, M., Worthington, J., Czajkowska, B., Kostro, K., Wiaderkiewicz, R., & Bajor, G. (2012). Nesfatin-1, a unique regulatory neuropeptide of the brain. Neuropeptides, 46(3), 105–112. https://doi.org/10.1016/j.npep.2011.12.002
Patel, L., Buckels, A. C., Kinghorn, I. J., Murdock, P. R., Holbrook, J. D., Plumpton, C., … Smith, S. A. (2003). Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators. Biochemical and Biophysical Research Communications, 300(2), 472–476. https://doi.org/10.1016/s0006-291x(02)02841-3
Potes, C. S., & Lutz, T. A. (2010). Brainstem mechanisms of amylin-induced anorexia. Physiology & Behavior, 100(5), 511–518. https://doi.org/10.1016/j.physbeh.2010.03.001
Potes, C. S., Lutz, T. A., & Riediger, T. (2010). Identification of central projections from amylin-activated neurons to the lateral hypothalamus. Brain Research, 1334, 31–44. https://doi.org/10.1016/j.brainres.2010.03.114
Psilopanagioti, A., Nikou, S., Logotheti, S., Arbi, M., Chartoumpekis, D. V., & Papadaki, H. (2022). Glucagon-like Peptide-1 receptor in the human hypothalamus is associated with body mass index and Colocalizes with the Anorexigenic neuropeptide Nucleobindin-2/Nesfatin-1. International Journal of Molecular Sciences, 23(23), 14899. https://doi.org/10.3390/ijms232314899
Rodriguez, A., Gomez-Ambrosi, J., Catalan, V., Ezquerro, S., Mendez-Gimenez, L., Becerril, S., … Fruhbeck, G. (2016). Guanylin and uroguanylin stimulate lipolysis in human visceral adipocytes. International Journal of Obesity, 40(9), 1405–1415. https://doi.org/10.1038/ijo.2016.66
Rupp, S. K., Wolk, E., & Stengel, A. (2021). Nesfatin-1 receptor: Distribution, signaling and increasing evidence for a G protein-coupled receptor - a systematic review. Front Endocrinology (Lausanne), 12, 740174. https://doi.org/10.3389/fendo.2021.740174
Sainsbury, A., Shi, Y. C., Zhang, L., Aljanova, A., Lin, Z., Nguyen, A. D., … Lin, S. (2010). Y4 receptors and pancreatic polypeptide regulate food intake via hypothalamic orexin and brain-derived neurotropic factor dependent pathways. Neuropeptides, 44(3), 261–268. https://doi.org/10.1016/j.npep.2010.01.001
Sedlackova, D., Kopeckova, J., Papezova, H., Hainer, V., Kvasnickova, H., Hill, M., & Nedvidkova, J. (2012). Comparison of a high-carbohydrate and high-protein breakfast effect on plasma ghrelin, obestatin, NPY and PYY levels in women with anorexia and bulimia nervosa. Nutrition & Metabolism, 9, Article 52. https://doi.org/10.1186/1743-7075-9-52
Seidel, M., Markmann Jensen, S., Healy, D., Dureja, A., Watson, H. J., Holst, B., … Sjogren, J. M. (2021). A systematic review and meta-analysis finds increased blood levels of all forms of ghrelin in both restricting and binge-eating/purging subtypes of anorexia nervosa. Nutrients, 13(2), 709. https://doi.org/10.3390/nu13020709
Shankar, S. S., Shankar, R. R., Mixson, L. A., Miller, D. L., Pramanik, B., O’Dowd, A. K., … Kelley, D. E. (2018). Native oxyntomodulin has significant glucoregulatory effects independent of weight loss in obese humans with and without type 2 diabetes. Diabetes, 67(6), 1105–1112. https://doi.org/10.2337/db17-1331
Smith, K. R., & Moran, T. H. (2021). Gastrointestinal peptides in eating-related disorders. Physiology & Behavior, 238, 113456. https://doi.org/10.1016/j.physbeh.2021.113456
Stengel, A., Goebel-Stengel, M., Teuffel, P., Hofmann, T., Busse, P., Kobelt, P., et al. (2014). Obese patients have higher circulating protein levels of dipeptidyl peptidase IV. Peptides, 61, 75–82. https://doi.org/10.1016/j.peptides.2014.09.006
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., … Lazar, M. A. (2001). The hormone resistin links obesity to diabetes. Nature, 409(6818), 307–312. https://doi.org/10.1038/35053000
Syk, M., Ramklint, M., Fredriksson, R., Ekselius, L., & Cunningham, J. L. (2017). Elevated total plasma-adiponectin is stable over time in young women with bulimia nervosa. European Psychiatry, 41, 30–36. https://doi.org/10.1016/j.eurpsy.2016.09.006
Tagami, T., Satoh, N., Usui, T., Yamada, K., Shimatsu, A., & Kuzuya, H. (2004). Adiponectin in anorexia nervosa and bulimia nervosa. The Journal of Clinical Endocrinology and Metabolism, 89(4), 1833–1837. https://doi.org/10.1210/jc.2003-031260
Terra, X., Auguet, T., Quesada, I., Aguilar, C., Luna, A. M., Hernandez, M., … Richart, C. (2012). Increased levels and adipose tissue expression of visfatin in morbidly obese women: The relationship with pro-inflammatory cytokines. Clinical Endocrinology, 77(5), 691–698. https://doi.org/10.1111/j.1365-2265.2011.04327.x
Thundyil, J., Pavlovski, D., Sobey, C. G., & Arumugam, T. V. (2012). Adiponectin receptor signalling in the brain. British Journal of Pharmacology, 165(2), 313–327. https://doi.org/10.1111/j.1476-5381.2011.01560.x
Tyszkiewicz-Nwafor, M., Slopien, A., Dmitrzak-Weglarz, M., & Rybakowski, F. (2019). Adiponectin and resistin in acutely ill and weight-recovered adolescent anorexia nervosa: Association with psychiatric symptoms. The World Journal of Biological Psychiatry, 20(9), 723–731. https://doi.org/10.1080/15622975.2018.1492735
Tyszkiewicz-Nwafor, M., Dutkiewicz, A., Paszynska, E., Dmitrzak-Weglarz, M., & Slopien, A. (2021). Omentin and visfatin in adolescent inpatients with anorexia nervosa; association with symptoms. Neuropeptides, 86, 102133. https://doi.org/10.1016/j.npep.2021.102133
Uhlen, M., Fagerberg, L., Hallstrom, B. M., Lindskog, C., Oksvold, P., Mardinoglu, A., … Ponten, F. (2015). Proteomics. Tissue-based map of the human proteome. Science, 347(6220), 1260419. https://doi.org/10.1126/science.1260419
Vrang, N., Hansen, M., Larsen, P. J., & Tang-Christensen, M. (2007). Characterization of brainstem preproglucagon projections to the paraventricular and dorsomedial hypothalamic nuclei. Brain Research, 1149, 118–126. https://doi.org/10.1016/j.brainres.2007.02.043
Wielinga, P. Y., Lowenstein, C., Muff, S., Munz, M., Woods, S. C., & Lutz, T. A. (2010). Central amylin acts as an adiposity signal to control body weight and energy expenditure. Physiology & Behavior, 101(1), 45–52. https://doi.org/10.1016/j.physbeh.2010.04.012
Wynne, K., Park, A. J., Small, C. J., Patterson, M., Ellis, S. M., Murphy, K. G., … Bloom, S. R. (2005). Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects: A double-blind, randomized, controlled trial. Diabetes, 54(8), 2390–2395. https://doi.org/10.2337/diabetes.54.8.2390
Xie, H., Tang, S. Y., Luo, X. H., Huang, J., Cui, R. R., Yuan, L. Q., … Liao, E. Y. (2007). Insulin-like effects of visfatin on human osteoblasts. Calcified Tissue International, 80(3), 201–210. https://doi.org/10.1007/s00223-006-0155-7
Yamada, C. (2021). Involvement of ghrelin dynamics in stress-induced eating disorder: Effects of sex and aging. International Journal of Molecular Sciences, 22(21), 11695. https://doi.org/10.3390/ijms222111695
Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., … Kadowaki, T. (2003). Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature, 423(6941), 762–769. https://doi.org/10.1038/nature01705
Yang, J., Brown, M. S., Liang, G., Grishin, N. V., & Goldstein, J. L. (2008). Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell, 132(3), 387–396. https://doi.org/10.1016/j.cell.2008.01.017
Yi, M., Li, H., Wu, Z., Yan, J., Liu, Q., Ou, C., & Chen, M. (2018). A promising therapeutic target for metabolic diseases: Neuropeptide Y receptors in humans. Cellular Physiology and Biochemistry, 45(1), 88–107. https://doi.org/10.1159/000486225
Zwirska-Korczala, K., Konturek, S. J., Sodowski, M., Wylezol, M., Kuka, D., Sowa, P., … Brzozowski, T. (2007). Basal and postprandial plasma levels of PYY, ghrelin, cholecystokinin, gastrin and insulin in women with moderate and morbid obesity and metabolic syndrome. Journal of Physiology and Pharmacology, 58(Suppl 1), 13–35. https://www.ncbi.nlm.nih.gov/pubmed/17443025
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The study was supported by the Ministry of Health of the Czech Republic, grant nr. NU20-04-00088, NU22-04-00010 and NU23-04-00381
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Prochazkova, P., Roubalova, R., Papezova, H. (2023). Peripheral Modulators of Appetite in Eating Disorders. In: Robinson, P., Wade, T., Herpertz-Dahlmann, B., Fernandez-Aranda, F., Treasure, J., Wonderlich, S. (eds) Eating Disorders. Springer, Cham. https://doi.org/10.1007/978-3-030-97416-9_113-1
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