Abstract
The abdominal organs are subject to marked functional changes due to alterations in both physical pressure and perfusion due to the nature of the viscera themselves, the tendency for inflammatory fluid to accumulate within the abdominal compartment, and even physical changes in the container and contiguous body cavities. When intra-compartment pressure is abnormally increased, this situation is designated as intra-abdominal hypertension (IAH). When IAH is to a degree that causes new and overt organ failure, the abdominal compartment syndrome (ACS) is defined. When the overt ACS ensues with catastrophic cardiorespiratory collapse, urgent laparotomy without subsequent abdominal wall closure is required to prevent death. The resulting open abdomen (OA), while lifesaving in this situation, introduces another series of risks to the patient that must be mitigated by a temporary abdominal closure (TAC) device. With only embarrassingly recent worldwide rationalization of fluid resuscitation strategies during critical injury and illness, the remarkable degree of iatrogenicity in cases of overt ACS is increasingly being appreciated. When balanced resuscitation formulas with increased blood and plasma and dramatically reduced volumes of crystalloid fluids are utilized, markedly reduced rates of IAH/ACS are seen. After traumatic injury the rationale for the use of the OA is increasingly being questioned. Comparatively however, the use of the OA after source control laparotomies for intraperitoneal sepsis is increasingly being adopted without strong controlled evidence to its effectiveness. This has been partially supported by developments in TAC devices that offer greater safety and potentially even a therapeutic modality to mitigate the biomediator propagation leading to systemic inflammation in IAS. Thus, controlled studies to determine optimal therapies are urgently required.
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Keywords
- Intra-abdominal pressure
- Intra-abdominal hypertension
- Abdominal compartment syndrome
- Intra-abdominal sepsis
- Resuscitation
- Open abdomen
- Temporary abdominal coverage
- Negative pressure peritoneal therapy
- Biomediators
13.1 Introduction
The abdominal organs are subject to marked functional changes due to alterations in both physical pressure and perfusion due to the nature of the viscera themselves, the tendency for inflammatory fluid to accumulate within this container, and even physical changes in the container and contiguous body cavities [1,2,3,4]. The normal relaxed supine pressure within the peritoneal cavity, intra-abdominal pressure (IAP), is under 10 mmHg [5], with 12 mmHg being defined as the beginning range of IAH [6]. Many processes will increase the physical contents of the abdominal cavity such as ileus or obstruction of the hollow viscera or the accumulation of intraperitoneal fluids such as inflammatory ascites, enteric leakage, and/or hematoma. Finally, the container itself can be rendered non-compliant due to inflammation and resuscitation of the abdominal wall itself [7]. Ultimately when the abdominal contents are increased and especially if the abdominal compliance is decreased, the IAP will rise sometimes markedly [4, 8].
Thus, in any critical situation, IAH is common and associated with significant morbidity and mortality in critically ill and injured patients [1, 8]. IAH can be somewhat simply equated with malperfusion. The abdominal compartment syndrome (ACS) represents the end of a pathophysiologic spectrum beginning with normal intra-abdominal pressure (IAP) and proceeding through worsening grades of IAH [6]. By consensus, grades of progressive IAH are given as I–IV (Table 13.1) [6, 9]. We prefer the term “overt ACS” to describe a catastrophically ill/injured patient with severe IAH and new-onset cardiorespiratory and/or renal failure. The effects of IAH/ACS are not limited to intra-abdominal organs; they are enacted systemically through biomediator generation resulting in multiorgan dysfunction syndrome/multisystem organ failure and/or through polycompartmental pressure interactions [2, 6, 10].
13.1.1 Consensus Definitions of the World Society of the Abdominal Compartment Syndrome
Early barriers to studying and thus understanding the IAH/ACS phenomenon related to variable definitions and concepts in the world literature frequently preclude comparison of data and experience. A notable milestone in defining and subsequently studying IAH/ACS was the establishment of the World Society of the Abdominal Compartment Syndrome (wsacs.org) in 2004 to “promote research, foster education, and improve the survival of patients with IAH and ACS” [9, 11]. This group published expert consensus definitions relating to IAH/ACS in 2006 [9], clinical practice guidelines in 2007 [11], and recommendations for research methodology in 2009 [12]. In 2013, they updated their consensus definitions (Table 13.2) and clinical practice guidelines (Table 13.3) [6]. In these guidelines, a dedicated pediatric subcommittee evaluated the adult definitions for use among children [6]. The subcommittee set the value used to define IAH and ACS in children lower as physiologic IAP values in these patients are lower than in adults [6, 13, 14]. This highlights that alternate definitions and management strategies may be needed for other patient populations, including pregnant women [15], those with obesity [16] or undergoing complex abdominal wall reconstruction [17], and the elderly, which are areas requiring future research.
In an effort to maintain vigilance in preventing ACS, while emphasizing the need to better understand IAH and its relationship to abdominal wall physiology [2, 18], the group was rebranded as the “WSACS—The Abdominal Compartment Society” in 2015 [19]. The mission of the Society was broadened to maintain the need to understand the optimal treatment of overt ACS but even more importantly to study IAH in all manner of its acute and chronic forms as an independent and a multifactorial condition in human disease and injury. Further in 2016, the WSACS collaborated closely with the World Society of Emergency Surgery to review contemporary data and to produce consensus guidance statements for OA management that are congruent and follow upon the WSACS/ACS guidelines for IAH/ACS management [20, 21] (Table 13.4).
13.1.2 The Abdominal Compartment and Abdominal Compliance
The concept of abdominal compliance (AC) is critical to appreciate for emergency surgeons. Intra-abdominal pressure is the direct result of both the abdominal volume and the abdominal compliance [2, 4, 22]. The volume of the abdominal contents varies greatly with both physiological and pathophysiological conditions. The second paradigm-changing concept is the related appreciation that abdominal compliance is not fixed. Abdominal compliance is a dynamic property reflecting the underlying tissue properties and health of the abdominal wall, which also reflects the therapies administered to any patient in the inter- and perioperative periods [2, 4, 23].
13.1.3 Pathophysiology
Although centered upon the abdominal cavity, the pathophysiology of IAH/ACS affects the entire body physically and biochemically (Fig. 13.1). Cardiac output is reduced owing to decreased preload and right heart volumes. Although increased systemic vascular resistance initially maintains apparent blood pressure, decreases in preload from the pooling of blood in splanchnic and lower extremity vascular beds eventually lead to reduced central venous return [24,25,26,27,28]. Cardiac underfilling also occurs despite apparently increased central hemodynamic measurements (central venous pressure and pulmonary artery occlusion pressure).
A distended tight abdomen with IAH physically compresses the lungs especially at the bases created a restrictive lung disease model. As respiratory compliance decreases, mechanical ventilation with increased ventilatory pressures and decreased volumes becomes difficult [25, 29, 30]. The partial pressures of oxygen will decrease, and carbon dioxide will increase [30, 31]. Even modest IAH appears to exacerbate acute lung injury and the acute respiratory distress syndrome (ARDS). When IAP levels greater than 20 mmHg are applied to critically ill animals, a dramatic exacerbation of ARDS-associated pulmonary edema is evident [30, 32]. Furthermore, elevated IAP results in a stiffer chest wall with much lower transpulmonary pressures and therefore less susceptibility to ventilator-induced lung injury [33, 34].
Oliguria is a common manifestation of the ACS, noting that the degree of renal failure has a dose-dependant relationship with IAH [35,36,37]. Further, these effects are exaggerated by hypovolemia and positive end-expiratory pressure [31, 38], and renal failure is often multifactorial in critical care settings. Blood flow to the kidney operates in series, with a high-pressure capillary bed in the glomerulus having a mean pressure of about 60 mmHg, although mean capillary pressure of the peritubular capillary system operates at a mean pressure of approximately 13 mmHg [39]. Such pressure and flow relationships make the kidney’s very susceptible to IAH, and the renal recovery after decompression may be dramatic [40].
Beyond the heart, lungs, and kidneys, almost every other organ system is altered by IAH, even if the effects are not clinically overt. IAH appears to contribute to increased intracerebral pressure (ICP) via transmitted intrathoracic pressure [41, 42] to the extent that laparotomies have been reported to reduce ICP in patients with secondary ACS [43, 44]. Patients in shock are at a particularly high risk for splanchnic malperfusion because even modest elevations in IAP greatly reduce hepatic and splanchnic perfusion [45]. This effect is exacerbated by prior hemorrhage [46] and is observed at much lower IAPs than required to induce other clinical features of ACS.
13.1.4 Pathobiology of IAH/ACS
Owing to intra-compartment physiology, there is a marked reduction to all the viscera inducing relative or actual organ ischemia. This ischemia initiates the inflammatory cascade of vasoactive biomediators common to sepsis. The effects of IAH on the gut are similar to those of prolonged hypoperfusion, and therefore these two issues are compounding. In the face of IAH, the damaged gut seems to act as a continued source of inflammation propagating SIRS and potentiating MODS [47,48,49]. Even after resuscitation and normalization of hemodynamics, gut vasoconstriction persists and is further exacerbated by IAH. Even relatively mild IAH (e.g., an IAP of 15 mmHg) has been reported to decrease intestinal microcirculatory blood flow, increase bowel wall permeability, and induce irreversible gut histopathological changes, bacterial translocation, and multiorgan dysfunction syndrome [50,51,52]. Prolonged gut hypoperfusion can precipitate a severe inflammatory response due to mobilization of damage-associated molecular patterns (e.g., high mobility group box 1, heat shock proteins, s100 proteins, nucleic acids, and hyaluronan), pro-inflammatory cytokines, and other mediators [53]. Thus, IAH may help transition severe injury/infection to subsequent MODS.
This process itself may be exacerbated by series of physiologic stresses associated with prior priming of the immune system elements, such that IAH/ACS will be potentiated due to sequential physiological “hits,” which produce a self-perpetuating process termed the “acute intestinal distress syndrome” [54, 55]. In the first hit, resuscitation of patients in shock induces injury especially of the splanchnic circulation [50, 55, 56]. This “acute bowel injury” results in release of pro-inflammatory mediators into the peritoneum and systemic circulation, leading to neutrophil priming, increased intestinal wall permeability, extravasation of fluid into the bowel wall and mesentery, translocation of intestinal bacteria, and absorption of bacterial endotoxin [51, 57,58,59,60]. In any subsequent hit such as a severe infection or delayed bleeding requiring further resuscitation, the resultant abdominal visceral edema leads to further IAH, compressing intra-abdominal lymphatics and resulting in a progressive visceral malperfusion, mucosa-to-serosa intestinal necrosis, a further increase in bowel wall permeability, and heightened bacterial translocation/endotoxin absorption and release of pro-inflammatory mediators [51, 57]. Such a two-hit theory may explain why patients without a primary inciting cause of shock (e.g., during elective abdominal wall reconstruction) may sometimes tolerate IAH/ACS better than predicted [17, 61], if they do not suffer a secondary insult in the postoperative period.
13.1.5 Epidemiology of IAH/ACS in a Changing Playing Field
Although the incidence of IAH may have not changed substantially, that of overt postinjury ACS has markedly decreased presumably because of increased awareness and the use of prevention strategies [62,63,64]. These include damage control resuscitation and increasingly well-tolerated and effective methods of open abdominal management [62, 64]. Damage control resuscitation is a strategy characterized by rapid hemorrhage control, permissive hypotension, administration of blood products in a ratio approximating whole blood (i.e., 1:1:1 packed red blood cells/plasma/platelets), and minimization of crystalloid fluids [65]. Such balanced resuscitation practices appear to be one the most profound evolutions in critical care/trauma in the last several decades [66].
13.1.6 Diagnosis
A critical pitfall is assuming that IAH/ACS can be excluded clinically without measuring IAP. Clinical examination, however, is unfortunately insufficient for detecting raised IAP [67, 68]. The current gold standard technique for diagnosis uses the urinary bladder for pressure transduction [6]. It is recommended that patients be supine with relaxed abdominal musculature in the end-expiratory phase of respiration and the transducer zeroed at the iliac crest in the midaxillary line [6]. The requirement for supine positioning is often a logistical barrier to frequent measurements in the critically ill/injured and a potential liability regarding supine positioning. Thus, corrections that allow inference of the effective IAP without recumbency or understanding the implications of IAP measurement at the phlebostatic axis are attractive, but not yet widely implemented [69,70,71].
13.2 Management of IAH/ACS
The updated 2013 consensus management statements and management algorithm of the WSACS are outlined in Table 13.3 and Fig. 13.2, respectively [9]. These recommendations represent the best efforts of an International Collaboration led by the WSACS to update the previous definitions [9] and recommendations [11] based on scientific progress over a decade in studying IAH/ACS [72]. It is hoped that these guidelines will require frequent updating as new scientific evidence emerges from well-performed studies.
13.2.1 Medical and Percutaneous Management
Several medical and minimally invasive management options for IAH and ACS exist. Although many have not been well studied, these should be instituted prior to surgical intervention where safe and feasible. The WSACS medical management algorithm is outlined in Fig. 13.3 [3].
Medical management strategies may be broadly divided into those that may increase abdominal wall compliance (sedation/analgesia and neuromuscular-blocking agents), evacuate gastrointestinal contents (nasogastric/rectal tubes and prokinetic agents), and decrease fluid balance [6]. As ileus and a positive fluid balance are significant and potentially modifiable risk factors for IAH in critically ill adults [73], decompressing enteral tubes should be used in patients with gastrointestinal tract distention, and a positive patient fluid balance should be avoided after the acute resuscitation phase has been completed [6]. Damage control resuscitation should be adopted in managing trauma patients with significant hemorrhage as it has been reported to be associated with a lower incidence of ACS and higher primary fascial closure (i.e., same-hospital-stay abdominal fascia-to-fascia closure) rates after damage control laparotomy when compared to traditional, crystalloid-focused resuscitation [74, 75]. Finally, although no studies have examined whether sedative or analgesic agents decrease IAP, neuromuscular-blocking agents are associated with a decrease in IAP and may be used in patients with ACS as a rescue treatment until another more definitive therapy can be performed [6, 76].
Percutaneous catheter drainage is a minimally invasive option suggested to decrease IAP in those with IAH/ACS [6, 77]. This intervention has been reported to effectively reduce IAP among patients with burns/acute pancreatitis and drainable closure rates after damage control laparotomy when compared to traditional, crystalloid-focused resuscitation [56, 57]. Percutaneous catheter drainage is a minimally invasive option suggested to decrease IAP in those with IAH/ACS [77, 78]. This intervention has been reported to effectively reduce IAP among patients with burns/acute pancreatitis and drainable intraperitoneal fluid collections. A case-control study of 62 patients with IAH/ACS and free intraperitoneal fluid or blood also reported that percutaneous catheter drainage was as effective as decompressive laparotomy at decreasing IAP and may avoid need for abdominal decompression in up to 81% of patients [79]. In this study, risk factors for percutaneous catheter drainage treatment failure included drainage of less than 1000 mL of fluid or a decrease in IAP of less than 9 mmHg in the first 4 h after catheter insertion [79, 80].
13.2.2 Surgical Management of IAH/ACS
Case reports/series have recently examined whether one of a number of different minimally invasive fasciotomy methods may be used instead of decompressive laparotomy in patients with largely secondary causes of ACS [77, 81, 82]. These studies have reported improvements in IAP and urine output [77]. Methods evaluated have included subcutaneous anterior rectus sheath fasciotomies, midline subcutaneous fasciotomy, bilateral subcutaneous anterior rectus abdominis muscle fasciotomy, subcutaneous or open linea alba fasciotomy, and midline subcutaneous fasciotomy [77].
If medical and less invasive strategies for treating IAH/ACS have failed, however, then decompressive laparotomy is lifesaving and should be expediently performed. From a realistic viewpoint, the surgical management of IAH/ACS can be functionally equated to managing the resultant OA with an overall goal of formally closing it as soon as it is safe. The entire potential spectrum of this management can be conceptualized as potentially occurring in up to six stages. These include surgical prevention of IAH/ACS; abdominal decompression (via laparotomy or a minimally invasive fasciotomy); temporary abdominal closure with a temporary abdominal closure (TAC) device; initial management of the open abdominal wound in the ICU; avoidance of wound complications, including deep soft tissue infections, abdominal abscesses, entero-atmospheric fistulae, and complex ventral herniae; and staged abdominal reconstruction (reducing and closing the abdominal defect over time) or, as a last resort, the use of a planned ventral hernia (an open abdominal wound that is allowed to granulate and covered with skin flaps or a split-thickness skin graft) with plans for delayed abdominal wall reconstruction.
It should be emphasized that the contemporary surgeons’ obvious goal should be to avoid all these stages if possible, or to minimize them, yet ensuring that the patient survives. In this current era of aggressive non-operative management, it is not a success if the patients succumb due to lack of an intervention. If prophylaxis or medical therapy can avoid or mitigate IAH, then no other interventions may be required. After decompressive laparotomy therefore, primary fascial closure is the goal. IAH/ACS may potentially be completely prevented after laparotomy by leaving the abdomen open where appropriate. However, for surgeons to recognize “when it’s appropriate” however is a challenging target within a rapidly moving playing field. While a decade ago surgeons would accept that almost any seriously injured patient requiring a laparotomy would subsequently require postoperative OA to prevent postinjury ACS [83], this dictum is no longer assured related to rationalized resuscitation strategies. As there is a vacuum of scientific data, opinion is the highest level of guidance. A recent expert appropriateness rating study concluded that appropriate indications for OA use remain the development of a coagulopathy (especially when combined with hypothermia and acidosis), administration of large volumes of crystalloids or packed red blood cells, inability to close the abdominal fascia without tension, development of signs of ACS during attempted abdominal wall closure, and need for a planned relaparotomy to remove intra-abdominal packs or reassess extent of bowel viability [84,85,86].
To assist clinicians the World Society of Emergency Surgery in conjunction with the Abdominal Compartment Society recently published consensus guidelines on managing the open abdomen [20, 21, 87]. The summarized recommendations regarding management are presented in Table 13.4.
13.2.3 Temporary Abdominal Closure (TAC) Devices
It is implicit in now accepting an OA that an acceptable and safe temporary abdominal closure (TAC) device be utilized to protect the viscera and manage the peritoneal cavity. Current WSACS/ACS and WSES guidelines recommend the use of negative pressure peritoneal therapy (NPPT) with either noncommercial (i.e., the Barker’s vacuum pack) or commercial active negative pressure wound therapy devices be used for temporary abdominal closure [6, 20]. Other contemporary reviews have also suggested the use of fascial traction methods in addition to NPPT, in a technique known as vacuum-assisted wound closure and mesh-mediated fascial traction (VAWCM) [88,89,90], is the preferred therapy [91], although there is minimal controlled evidence to base decision-making upon.
While open abdomen therapy was described as far back as 1940 using light canvas covered in Vaseline [92], there has been a rapid evolution in TAC devices. Using plastic bags that did not adhere to the viscera was an advantage of the so-called Bogota bag. Subsequently a number of important principles regarding TAC devices have been recognized. The TAC should be placed well within the peritoneal cavity to maintain as much lateral separation of the viscera from the abdominal wall. It should prevent lateralization of the abdominal musculature which is an important function of VAWCM. It should preferably control peritoneal fluids, which may be one of its most unappreciated benefits.
Preclinical studies have reported that application of negative pressure to the open abdominal wound (i.e., “negative pressure peritoneal therapy”) [93] may remove ascites and peritoneal pro-inflammatory mediators, reduce the systemic inflammatory response, and improve the structure and potentially function of the pulmonary, cardiac, and renal systems [94, 95]. A prospective cohort study of 280 patients published in 2013 reported that the use of the ABThera negative pressure wound therapy device (Kinetic Concepts Inc., San Antonio, Texas, USA) was associated with improved primary fascial closure rates and survival when compared with a device that provides potentially less efficient peritoneal negative pressure, the Barker’s vacuum pack [96]. To date, only one RCT published in 2015 has been designed to determine if the ABThera is more efficacious than the Barker’s vacuum pack at reducing the extent of the systemic inflammatory response after damage control laparotomy for intra-abdominal injury or sepsis [97]. This trial reported an improved survival with the ABThera that did not appear to be mediated by an improvement in peritoneal fluid drainage, markers of the systemic inflammatory response, or primary fascial closure rates [97].
After decompressive laparotomy, if the abdominal fascia is unable to be closed when the patient is first returned to the operating room, a staged abdominal reconstruction method may be used. These methods have been proposed to include negative pressure peritoneal therapy, the Wittmann Patch (Starsurgical, Burlington, Wisconsin, USA), progressive closure of a synthetic patch sutured between the fascial edges, dynamic retention using sutures or the Abdominal Reapproximation Anchor device (Canica Design Inc., Almonte, Ontario, Canada), and vacuum-assisted wound closure (VAC) and mesh-mediated fascial traction. Although no comparative trials have been completed, VAC and mesh-mediated fascial traction has likely received the greatest enthusiasm as it is associated with fascial closure rates of at least 77% [88, 91, 98]. In this method, patients are fitted with a VAC device at the initial laparotomy [88, 99]. At relaparotomy, a perforated polyurethane sheet is placed over the visceral block and a divided polypropylene mesh sheet sutured between the fascial edges. This sheet is subsequently sutured together before a VAC dressing is placed atop and negative suction applied. The VAC dressing is then changed and mesh progressively tightened every 24–72 h until the fascial edges can be reapproximated.
13.2.4 Direct Peritoneal Resuscitation
DPR involves infusion of hypertonic fluid into the abdomen in addition to IV resuscitation. This causes rapid and sustained dilation of the arterioles, especially those in the intestine, which reduces organ ischemia and cellular hypoxia [100, 101]. Data from single-center RCTs shows that NPWT and fluid instillation seem to improve outcomes in trauma patients in terms of early and primary closure [102, 103]. There is a good deal of animal work supporting the conclusion that DPR prevents intestinal ischemia and helps preserve intestinal blood flow and structural integrity and reduces inflammatory cytokines even in inflammatory states such as brain death [101, 104]. With replication of these experiences in other centers, this therapy may become part of the standard OA management.
13.2.5 Current Utilization of the Open Abdomen (OA)
13.2.5.1 The OA for Trauma Surgery
The use of the OA in trauma surgery is decreasing every year. With a dramatic evolution in resuscitation practices involving balanced resuscitation practices, more and more trauma patients who previously become so edematous required OA therapy, are no longer being crystalloid over-resuscitated, and can thus be primarily closed [64, 66, 105]. This dramatic change in the trauma care paradigm has justified questions regarding the whole premise of damage control surgery for trauma [63] and justifies the randomized control trial of the practice in trauma patients [106].
13.2.5.2 The OA for Intra-abdominal Sepsis
The use of the OA for non-trauma general surgery is however increasingly being reported in uncontrolled series as a potentially beneficial option for patients with SCIAS [107,108,109,110,111,112]. The use of the OA in severe sepsis may allow early identification and increased drainage of any residual infection, control any persistent source of infection, more effectively remove biomediator-rich peritoneal fluid, provide prophylaxis against development of the abdominal compartment syndrome, and allow for the safe deferral of gastrointestinal anastomoses in settings where the risk of anastomotic leak is initially high [111]. Although the WSACS/ACS guidelines recommended NOT to use the open abdomen for intra-abdominal sepsis [6], largely based on economic reasons [113], more contemporary WSES guidelines differ. The 2018 WSES guidelines on OA management state that the open abdomen is an option for emergency surgery patients with severe peritonitis and severe sepsis/septic shock under the following circumstances: abbreviated laparotomy due to severe physiological derangement, the need for a deferred intestinal anastomosis, a planned second look for intestinal ischemia, persistent source of peritonitis (failure of source control), or extensive visceral edema with the concern for development of abdominal compartment syndrome, albeit with the lowest confidence due to the level of evidence (Grade 2C) [20].
Compared to trauma patients, however, patients undergoing OA management for intra-abdominal sepsis have a greater risk of OA complications, including entero-atmospheric fistula (EAF) and intra-abdominal abscess formation, and a lower rate of primary fascial closure (i.e., fascia-to-fascia closure within the index hospitalization) [87, 91, 111, 114, 115]. Risk factors for frozen abdomen and EAF in OA are delayed abdominal closure, non-protection of bowel loops during OA, the presence of bowel injury and repairs or anastomosis, colon resection during DCS, the large fluid resuscitation volume (> 5 L/24 h), the presence of intra-abdominal sepsis/abscess, and the use of polypropylene mesh directly over the bowel [116,117,118,119,120]. Although RCT data comparing techniques is needed, meta-analyses conducted by our group [121] and the Amsterdam group [91] have concluded that negative pressure wound therapy (NPWT) treatment appears to potentially be the safest and most effective OA management technique currently available. Newer commercial active negative pressure peritoneal therapy (ANPPT) systems now available for OA may reduce the risk of enterocutaneous fistula and facilitate enhanced delivery of negative peritoneal pressure to the peritoneal cavity [1, 6, 121].
Animal studies [94] and in silico modeling of these animal studies [95] have shown that ANNPT provides a greater degree of negative pressure throughout the peritoneum, which may reduce plasma biomediator levels when compared to a more passive peritoneal drainage. Systemic inflammation (TNF-α, IL-1β, IL-6) in one study was significantly reduced in the ANPPT group and was associated with significant improvement in intestine, lung, kidney, and liver histopathology [94]. Although the mortality rate in the NPPT was 17% versus 50% in the control group, this difference was not statistically significant (p = 0.19), likely due to the smaller numbers.
As over-resuscitation becomes rare and de-resuscitation becomes a focus [122], it is intuitive that there will be more abdomens in non-trauma intra-abdominal sepsis patients who may be technically closed without inducing intra-abdominal hypertension (IAH). However, although these abdomens may be closed, should they be closed? As has been recently emphasized, there are profound differences in the basic science of sepsis and traumatic injury [123], with the previously unifying concepts of noninfectious systemic inflammatory response syndrome (SIRS) being effectively discarded as a clinically helpful construct [124,125,126]. The one nebulous, poorly defined “holy grail” of the optimal management of SCIAS is adequate “source control.” It is suggested that even if an abdomen can be physically closed that there may be an advantage to leaving it open to allow better drainage of intraperitoneal contamination, a concept that is supported by remarkable animal lab data suggests the ability of ANPPT to mitigate the elaboration of the inflammatory biomediator cascade [94, 95, 127]. Coupled with technical advances in ANPPT dressings that are safer to utilize and that increasingly protect the viscera, this appears an attractive option for the sickest IAS patients.
13.3 Conclusion
The use of the OA after source control laparotomies for intraperitoneal sepsis is increasingly being adopted without strong controlled evidence to its effectiveness. This has been partially supported by developments in TAC devices that offer greater safety and potentially even a therapeutic modality to mitigate the biomediator propagation leading to systemic inflammation in IAS. Thus, controlled studies to determine optimal therapies are urgently required. The surgical and critical care communities must therefore design RCTs to re-examine whether negative pressure wound therapy improves outcomes over alternate temporary abdominal closure methods in critically ill adults (and determine how this occurs), to determine the optimal method of staged abdominal reconstruction in patients with open abdominal wounds, and to study the role of IAH in critical care both as an independent and how it interacts in a multifactorial way with other physiological stressors in critical illness and injury. Thus, the next decade of study related to IAH/ACS will therefore be one aimed at understanding which treatments may effectively lower IAP and whether these treatments ultimately influence patient important outcomes.
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Kirkpatrick, A.W., Roberts, D.J., Coccolini, F. (2019). Intra-Abdominal Hypertension, Abdominal Compartment Syndrome and the Open Abdomen: Looking Beyond the Obvious to New Understandings in Pathophysiology, Harm-Reduction and Systemic Therapies. In: Picetti, E., Pereira, B., Razek, T., Narayan, M., Kashuk, J. (eds) Intensive Care for Emergency Surgeons. Hot Topics in Acute Care Surgery and Trauma. Springer, Cham. https://doi.org/10.1007/978-3-030-11830-3_13
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