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Targeting Redox Homeostasis of Tumor Cells by Therapeutic Compounds in Cancer

An Indian Perspective

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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

Abstract

Cancer is one of the significant causes of morbidity and mortality in the world. The role of oxidative stress in tumor progression and metastasis has been under focus since the last two decades, suggesting the importance of redox balance upon which cancer cells thrive to promote oncogenic phenotype. Therefore, it is highly warranted to develop therapies that can disrupt the fine-tuned intracellular reactive oxygen species (ROS) balance of tumor cells. Even though classical chemotherapy, radiotherapy, and many FDA-approved chemotherapeutic drugs modulate ROS levels, the associated side effects make it worthwhile to explore alternative options. Various compounds of natural origin have high efficacy and minimum side effects and pose a low risk of recurrence. This chapter has been compiled to give a thorough account of medicinal plants of Indian origin that have been implicated in ROS modulation and their potential applications in clinical settings.

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Authors and Affiliations

  1. Department of Human Genetics and Molecular Medicine, Central University of Punjab, Bathinda, India

    Kanika Vasudeva, Pragya Chaturvedi, Rahul Khan, Prachi Sahu & Anjana Munshi

Authors
  1. Kanika Vasudeva
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  2. Pragya Chaturvedi
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  3. Rahul Khan
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  4. Prachi Sahu
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  5. Anjana Munshi
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Corresponding author

Correspondence to Anjana Munshi .

Editor information

Editors and Affiliations

  1. Dept Biochem & Biophysics, C-Block, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

Section Editor information

  1. Department of Internal Medicine, General Hospital Minamiseiko Hospital, Nagoya, Japan

    Takehiko Takayanagi

  2. Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA

    Prakash Radhakrishnan

  3. Department of Nutrition and Dietetics, Faculty of Health Sciences, Bezmialem Vakif University, Istanbul, Turkey

    Ayse Günes-Bayir

  4. Department of Biomedical Sciences, University of Illinois College of Medicine, Rockford, Illinois, USA

    Gnanasekar Munirathinam

  5. Dean, Research, Central University of Punjab, Bathinda, Punjab, India

    Anjana Munsi

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Vasudeva, K., Chaturvedi, P., Khan, R., Sahu, P., Munshi, A. (2022). Targeting Redox Homeostasis of Tumor Cells by Therapeutic Compounds in Cancer. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-1247-3_271-1

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  • DOI: https://doi.org/10.1007/978-981-16-1247-3_271-1

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