Abstract
While recognizing the differences in the pathogenesis of different malignancies, the outstanding body of evidence has been accumulated in the past few decades, implicating the role of oxidative stress in the process of cancer initiation and progression. Cancer cells exhibit an altered energy metabolism and highly efficient redox systems that enable rapid cell proliferation and survival in various conditions. The adaptation/resistance of cancer cells to chronic oxidative stress through different mechanisms usually leads to drug resistance. The specific disruption of the redox capacity with either scavenging the excessive intracellular ROS or inducing ROS generation through exogenous oxidative insult represents a promising approach for cancer therapy. A considerable research effort has been dedicated to identifying the therapeutic agents with redox-modulation capacity that may impede cancer. Based on the established knowledge in these subjects, the natural and synthetic redox modulators currently used or under investigation for their potential application in the oxidative stress-targeted cancer therapy are reviewed.
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This work was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia (Grant No. 451-03-9/2021-14/200017).
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Petrovic, S., Leskovac, A. (2021). Prospective Application of Natural and Synthetic Redox Modulators in Oxidative Stress-Targeted Cancer Therapy. In: Chakraborti, S., Ray, B.K., Roychowdhury, S. (eds) Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-15-4501-6_130-1
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