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What We Have Learned from Animal Models of HCMV

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Human Cytomegaloviruses

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1119))

Abstract

Although human cytomegalovirus (HCMV) primary infection is generally asymptomatic, in immune-compromised patients HCMV increases morbidity and mortality. As a member of the betaherpesvirus family, in vivo studies of HCMV are limited due to its species specificity. CMVs from other species are often used as surrogates to express HCMV genes/proteins or used as models for inferring HCMV protein function in humans. Using innovative experiments, these animal models have answered important questions about CMV’s life cycle, dissemination, pathogenesis, immune evasion, and host immune response. This chapter provides CMV biologists with an overview of the insights gained using these animal models. Subsequent chapters will provide details of the specifics of the experimental methods developed for each of the animal models discussed here.

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Authors and Affiliations

  1. Department of Microbiology, University of Tennessee, Knoxville, TN, USA

    Pranay Dogra

  2. Department of Microbiology, The University of Tennessee, 1414 Cumberland Ave, WLS F417, Knoxville, TN, 37996, USA

    Tim E. Sparer

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  1. Pranay Dogra
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  2. Tim E. Sparer
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Correspondence to Tim E. Sparer .

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  1. Department of Microbiology & Immunology, Louisiana State University Health Scienc, Shreveport, Louisiana, USA

    Andrew D. Yurochko

  2. Department of Molecular Genetics, University of Cincinnati College of Medi, Cincinnati, Ohio, USA

    William E. Miller

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Dogra, P., Sparer, T.E. (2014). What We Have Learned from Animal Models of HCMV. In: Yurochko, A., Miller, W. (eds) Human Cytomegaloviruses. Methods in Molecular Biology, vol 1119. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-788-4_15

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