Summary
This essay provides an informal review of the modern systems-centric biological methodology for the practical researcher. The systems approach is defined, and a generic recipe for employing it in biomedical research is offered. General caveats are discussed that pertain to biological complexity, to explanation in molecular terms, and to bottom-up investigation. An outlook on the development of systems biology is also given.
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References
Mesarović, M. D. (1968) Systems theory and biology--view of a theoretician, in Systems Theory and Biology (Mesarović, M. D., ed.) Springer, New York, pp. 59–87.
Kitano, H. (2002) Systems biology: A brief overview. Science 295, 1662–1664.
Hood, L., Heath, J. R., Phelps, M. E., and Lin, B. (2004) Systems biology and new technologies enable predictive and preventative medicine. Science 306, 640–643.
Westerhoff, H. V. and Alberghina, L. (2005) Systems biology: did we know it all along? in Systems Biology: Definitions and Perspectives (Alberghina, L. and Westerhoff, H. V., eds.) Springer, Berlin, pp. 3–9.
Ideker, T., Winslow, L. R., and Lauffenburger, D. A. (2006) Bioengineering and systems biology. Ann. Biomed. Eng. 34, 257–264.
Garfinkel, D. (1980) Computer modeling, complex biological systems, and their simplifications. Am. J. Physiol. 239, Rl–R6.
Miller, G. A. (1956) The magical number seven, plus or minus two. Some limits on our capacity for processing information. Psychol. Rev. 63, 81–97.
Kirschner, M., Gerhart, J., and Mitchison, T. (2000) Molecular “vitalism”. Cell 100, 79–88.
Albrecht-Buehler, G. (1990) In defense of “nonmolecular” cell biology. Int. Rev. Cytol. 120, 191–241.
Shrager, J. (2003) The fiction of function. Bioinformatics 19, 1934–1936.
Bradley, D. F. (1968) Multilevel systems and biology--view of a submolecular biologist, in Systems Theory and Biology (Mesarović, M. D., ed.) Springer, New York, pp. 38–58.
Harold, F. M. (2001) The Way of the Cell. Oxford, New York.
Yates, F. E., Brennan, R. D., Urquhart, J., Dallman, M. F., Li, C. C., and Halperin, W. (1968) A continuous system model of adrenocortical function, in Systems Theory and Biology (Mesarović, M. D., ed.) Springer, New York, pp. 141–184.
Doyle, J. (2001) Computational biology: Beyond the spherical cow. Nature 411, 151–152.
Yamamoto, W. S. and Walton, E. S. (1975) On the evolution of the physiological model. Annu. Rev. Biophys. Bioeng. 4, 81–102.
Heinrich, R. and Rapoport, T. A. (1974) A linear steady-state treatment of enzymatic chains. General properties, control and effector strength. Eur. J. Biochem. 42, 89–95.
Oosawa, F. and Asakura, S. (1975) Thermodynamics of the Polymerization of Protein. Academic Press, New York.
Wiley, H. S. (2008) Think like a cockroach. The Scientist 22, 29.
Weaver, W. (1948) Science and complexity. Am. Scientist 36, 536.
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© 2009 Humana Press
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Maly, I. (2009). Introduction: A Practical Guide to the Systems Approach in Biology. In: Maly, I. (eds) Systems Biology. Methods in Molecular Biology, vol 500. Humana Press. https://doi.org/10.1007/978-1-59745-525-1_1
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DOI: https://doi.org/10.1007/978-1-59745-525-1_1
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