Summary
The xenotransplantation model has been instrumental for the identification and characterization of human leukemic stem cells. In this chapter we will discuss the development of the immunodeficient model in the understanding of leukemogenesis, describe the different models of immunodeficiency now available and their values, as well as describe the methods used for the purification of LSCs. We will concentrate on the model of acute myeloid leukemia, as it was the first type of leukemia for which the xenotransplantation model was developed.
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The author thanks Mr. Christopher Ridler and Dr. Daniel Pearce for their assistance in the preparation of this manuscript.
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Bonnet, D. (2009). Humanized Model to Study Leukemic Stem Cells. In: Eric So, C.W. (eds) Leukemia. Methods in Molecular Biology™, vol 538. Humana Press. https://doi.org/10.1007/978-1-59745-418-6_12
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DOI: https://doi.org/10.1007/978-1-59745-418-6_12
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