Abstract
The number and type of neuropsychiatric conditions being treated by transcranial magnetic stimulation (TMS) is ever increasing. In addition, the parameters utilized to treat these conditions are ever evolving. In this chapter, we explore the evidence concerning the efficacy of TMS to treat a number of psychiatric and physiological conditions: including depression, obsessive compulsive disorder, schizophrenia, post traumatic stress disorder, chronic pain, tinnitus, stroke, and Parkinson’s disease. In addition, we outline the most commonly utilized protocols and parameters to treat each of the above conditions.
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References
Institute of Medicine (2001) Crossing the quality chasm: a new health system for the 21st century. Retrieved from: http://www.iom.edu/Global/News%20Announcements/Crossing-the-Quality-Chasm-The-IOM-Health-Care-Quality-Initiative.aspx
Phillips ML, Drevets WC, Rauch SL, Lane R (2003) Neurobiology of emotion perception II: Implications for major psychiatric disorders. Biol Psychiatry 54:515–528
Grimm S, Beck J, Schuepbach D, Hell D, Boesiger P, Bermpohl F, Niehaus L, Boeker H, Northoff G (2008) Imbalance between left and right dorsolateral prefrontal cortex in major depression is linked to negative emotional judgment: an fMRI study in severe major depressive disorder. Biol Psychiatry 63(4):369–376
Fitzgerald PB, Oxley TJ, Laird AR, Kulkarni J, Egan GF, Daskalakis ZJ (2006) An analysis of functional neuroimaging studies of dorsolateral prefrontal cortical activity in depression. Psychiatry Res 148(1):33–45
Charnsil C, Suttajit S, Boonyanaruthee V, Leelarphat S (2012) An open-label study of adjunctive repetitive transcranial magnetic stimulation (rTMS) for partial remission in major depressive disorder. Int J Psychiatry Clin Pract 16(2):98–102
Galletly C, Gill S, Clarke P, Burton C, Fitzgerald PB (2012) A randomized trial comparing repetitive transcranial magnetic stimulation given 3 days/week and 5 days/week for the treatment of major depression: is efficacy related to the duration of treatment or the number of treatments? Psychol Med 42(5):981–988
Fitzgerald PB, Hoy KE, Herring SE, McQueen S, Peachey AV, Segrave RA, Maller J, Hall P, Daskalakis ZJ (2012) A double blind randomized trial of unilateral left and bilateral prefrontal cortex transcranial magnetic stimulation in treatment resistant major depression. J Affect Disord 139(2):193–198
Eche J, Mondino M, Haesebaert F, Saoud M, Poulet E, Brunelin J (2012) Low- vs high-frequency repetitive transcranial magnetic stimulation as an add-on treatment for refractory depression. Front Psychiatry 3:13
Kuroda Y, Motohashi N, Ito H, Ito S, Takano A, Takahashi H, Nishikawa T, Suhara T (2010) Chronic repetitive transcranial magnetic stimulation failed to change dopamine synthesis rate: preliminary L-[β-11C]DOPA positron emission tomography study in patients with depression. Psychiatry Clin Neurosci 64(6):659–662
Pogarell O, Koch W, Pöpperl G, Tatsch K, Jakob F, Zwanzger P, Mulert C, Rupprecht R, Möller HJ, Hegerl U, Padberg F (2006) Striatal dopamine release after prefrontal repetitive transcranial magnetic stimulation in major depression: preliminary results of a dynamic [123I] IBZM SPECT study. J Psychiatr Res 40(4):307–314
O’Reardon JP, Solvason HB, Janicak PG, Sampson S, Isenberg KE, Nahas Z, McDonald WM, Avery D, Fitzgerald PB, Loo C, Demitrack MA, George MS, Sackeim HA (2007) Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial. Biol Psychiatry 62(11):1208–1216
George MS, Lisanby SH, Avery D, McDonald WM, Durkalski V, Pavlicova M, Anderson B, Nahas Z, Bulow P, Zarkowski P, Holtzheimer PE, Schwartz T, Sackeim HA (2010) Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder: a sham-controlled randomized trial. Arch Gen Psychiatry 67(5):507–516
Slotema CW, Blom JD, Hoek HW, Sommer IE (2010) Should we expand the toolbox of psychiatric treatment methods to include repetitive transcranial magnetic stimulation (rTMS)? A meta-analysis of the efficacy of rTMS in psychiatric disorders. J Clin Psychiatry 71(7):873–884
Boileau B (2011) A review of obsessive-compulsive disorder in children and adolescents. Dialogues Clin Neurosci 13(4):401–411
Saxena S, Rauch SL (2000) Functional neuroimaging and the neuroanatomy of obsessive–compulsive disorder. Psychiatr Clin North Am 23:563–586
Ting JT, Feng G (2011) Neurobiology of obsessive-compulsive disorder: insights into neural circuitry dysfunction through mouse genetics. Curr Opin Neurobiol 21(6):842–848
Sims A (2002) Symptoms in the Mind: An Introduction to Descriptive Psychopathology. W. B. Saunders, Philadelphia
Puri BK, Davey NJ, Ellaway PH, Lewis SW (1996) An investigation of motor function in schizophrenia using transcranial magnetic stimulation of the motor cortex. Br J Psychiatry 169(6):690–695
Fitzgerald PB, Brown TL, Daskalakis ZJ, Kulkarni J (2002) A transcranial magnetic stimulation study of inhibitory deficits in the motor cortex in patients with schizophrenia. Psychiatry Res 114(1):11–22
Daskalakis ZJ, Christensen BK, Chen R, Fitzgerald PB, Zipursky RB, Kapur S (2002) Evidence for impaired cortical inhibition in schizophrenia using transcranial magnetic stimulation. Arch Gen Psychiatry 59(4): 347–354
Reid PD, Daniels B, Rybak M, Turnier-Shea Y, Pridmore S (2002) Cortical excitability of psychiatric disorders: reduced post-exercise facilitation in depression compared to schizophrenia and controls. Aust N Z J Psychiatry 36(5):669–673
Wobrock T, Kadovic D, Falkai P (2007) Cortical excitability in schizophrenia: studies using transcranial magnetic stimulation. Nervenarzt 78(7):753–763
Freitas C, Fregni F, Pascual-Leone A (2009) Meta-analysis of the effects of repetitive transcranial magnetic stimulation (rTMS) on negative and positive symptoms in schizophrenia. Schizophr Res 108(1–3):11–24
Rauch SL, Shin LM, Phelps EA (2006) Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research—past, present, and future. Biol Psychiatry 60(4):376–382
Zippo AG, Storchi RM, Valente M, Caramenti GC, Biella GE (2011) Neural substrates of chronic pain in the thalamocortical circuit. Available from Nature Precedings http://hdl.handle.net/10101/npre.65481
May A (2007) Neuroimaging: visualising the brain in pain. Neurol Sci 28(Suppl 2):S101–S107
Ahn S, Lee SK (2011) Diffusion tensor imaging: exploring the motor networks and clinical applications. Korean J Radiol 12(6): 651–661
Guye M, Parker GJ, Symms M, Boulby P, Wheeler-Kingshott CA, Salek-Haddadi A, Barker GJ, Duncan JS (2003) Combined functional MRI and tractography to demonstrate the connectivity of the human primary motor cortex in vivo. Neuroimage 19(4):1349–1360
Laird AR, Robbins JM, Li K, Price LR, Cykowski MD, Narayana S, Laird RW, Franklin C, Fox PT (2008) Modeling motor connectivity using TMS/PET and structural equation modeling. Neuroimage 2:424–436
Hayashi T, Ohnishi T, Okabe S, Teramoto N, Nonaka Y, Watabe H, Imabayashi E, Ohta Y, Jino H, Ejima N, Sawada T, Iida H, Matsuda H, Ugawa Y (2004) Long-term effect of motor cortical repetitive transcranial magnetic stimulation [correction]. Ann Neurol 56(1):77–85, Erratum in: Ann Neurol, 56(2):311
Chouinard PA, Van Der Werf YD, Leonard G, Paus T (2003) Modulating neural networks with transcranial magnetic stimulation applied over the dorsal premotor and primary motor cortices. J Neurophysiol 90(2):1071–1083
Jankovic J (2008) Parkinson’s disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry 79:368–376
Lozano AM, Snyder BJ (2008) Deep brain stimulation for parkinsonian gait disorders. J Neurol 255(Suppl 4):30–31
Andrade P, Carrillo-Ruiz JD, Jiménez F (2009) A systematic review of the efficacy of globus pallidus stimulation in the treatment of Parkinson’s disease. J Clin Neurosci 16(7):877–881
Fregni F, Simon DK, Wu A, Pascual-Leone A (2005) Non-invasive brain stimulation for Parkinson’s disease: a systematic review and meta-analysis of the literature. J Neurol Neurosurg Psychiatry 76(12):1614–1623
Kolominsky-Rbas PL, Weber M, Gefeller O, Neundoerfer B, Heuschmann PU (2001) Epidemiology of ischemic stroke subtypes according to TOAST criteria: incidence, recurrence, and long-term survival in ischemic stroke subtypes: a population-based study. Stroke 32(12):2735–2740
Théoret H, Kobayashi M, Valero-Cabré A, Pascual-Leone A (2003) Exploring paradoxical functional facilitation with TMS. Suppl Clin Neurophysiol 56:211–219
Kaltenbach JA (2009) Insights on the origins of tinnitus: An overview of recent research. Hearing J 62(2):26–29
McNamara B, Ray JL, Arthurs OJ, Boniface S (2001) Transcranial magnetic stimulation for depression and other psychiatric disorders. Psychol Med 31(7):1141–1146
Holtzheimer PE 3rd, Russo J, Avery DH (2003) A meta-analysis of repetitive transcranial magnetic stimulation in the treatment of depression. Psychopharmacol Bull 35(4):149–169, Erratum in: Psychopharmacol Bull, 37(2), 5
Burt T, Lisanby SH, Sackeim HA (2002) Neuropsychiatric applications of transcranial magnetic stimulation: a meta analysis. Int J Neuropsychopharmacol 5(1):73–103
Martin JL, Barbanoj MJ, Schlaepfer TE, Thompson E, Pérez V, Kulisevsky J (2003) Repetitive transcranial magnetic stimulation for the treatment of depression. Systematic review and meta-analysis. Br J Psychiatry 182:480–491
Couturier JL (2005) Efficacy of rapid-rate repetitive transcranial magnetic stimulation in the treatment of depression: a systematic review and meta-analysis. J Psychiatry Neurosci 30(2):83–90
Herrmann LL, Ebmeier KP (2006) Factors modifying the efficacy of transcranial magnetic stimulation in the treatment of depression: a review. J Clin Psychiatry 67(12):1870–1876
Schutter DJ (2009) Antidepressant efficacy of high-frequency transcranial magnetic stimulation over the left dorsolateral prefrontal cortex in double-blind sham-controlled designs: a meta-analysis. Psychol Med 39(1):65–75
Greenberg BD, George MS, Martin JD, Benjamin J, Schlaepfer TE, Altemus M, Wassermann EM, Post RM, Murphy DL (1997) Effect of prefrontal repetitive transcranial magnetic stimulation in obsessive-compulsive disorder: a preliminary study. Am J Psychiatry 154(6):867–869
Alonso P, Pujol J, Cardoner N, Benlloch L, Deus J, Menchón JM, Capdevila A, Vallejo J (2001) Right prefrontal repetitive transcranial magnetic stimulation in obsessive-compulsive disorder: a double-blind, placebo-controlled study. Am J Psychiatry 158(7):1143–1145
Sachdev PS, McBride R, Loo CK, Mitchell PB, Malhi GS, Croker VM (2001) Right versus left prefrontal transcranial magnetic stimulation for obsessive-compulsive disorder: a preliminary investigation. J Clin Psychiatry 62(12):981–984
Prasko J, Pasková B, Záleský R, Novák T, Kopecek M, Bares M, Horácek J (2006) The effect of repetitive transcranial magnetic stimulation (rTMS) on symptoms in obsessive compulsive disorder. A randomized, double blind, sham controlled study. Neuro Endocrinol Lett 27(3):327–332
Mantovani A, Lisanby SH, Pieraccini F, Ulivelli M, Castrogiovanni P, Rossi S (2006) Repetitive transcranial magnetic stimulation (rTMS) in the treatment of obsessive-compulsive disorder (OCD) and Tourette’s syndrome (TS). Int J Neuropsychopharmacol 9(1):95–100
Sachdev PS, Loo CK, Mitchell PB, McFarquhar TF, Malhi GS (2007) Repetitive transcranial magnetic stimulation for the treatment of obsessive compulsive disorder: a double-blind controlled investigation. Psychol Med 37(11):1645–1649
Kang JI, Kim CH, Namkoong K, Lee CI, Kim SJ (2009) A randomized controlled study of sequentially applied repetitive transcranial magnetic stimulation in obsessive-compulsive disorder. J Clin Psychiatry 70(12):1645–1651
Sarkhel S, Sinha VK, Praharaj SK (2010) Adjunctive high-frequency right prefrontal repetitive transcranial magnetic stimulation (rTMS) was not effective in obsessive-compulsive disorder but improved secondary depression. J Anxiety Disord 24(5):535–539
Mantovani A, Simpson HB, Fallon BA, Rossi S, Lisanby SH (2010) Randomized sham-controlled trial of repetitive transcranial magnetic stimulation in treatment-resistant obsessive-compulsive disorder. Int J Neuropsychopharmacol 13(2):217–227
Mansur CG, Myczkowki ML, de Barros CS, Sartorelli Mdo C, Bellini BB, Dias AM, Bernik MA, Marcolin MA (2011) Placebo effect after prefrontal magnetic stimulation in the treatment of resistant obsessive-compulsive disorder: a randomized controlled trial. Int J Neuropsychopharmacol 14(10):1389–1397
Aleman A, Sommer IE, Kahn RS (2007) Efficacy of slow repetitive transcranial magnetic stimulation in the treatment of resistant auditory hallucinations in schizophrenia: a meta-analysis. J Clin Psychiatry 68(3): 416–421
Tranulis C, Sepehry AA, Galinowski A, Stip E (2008) Should we treat auditory hallucinations with repetitive transcranial magnetic stimulation? A metaanalysis. Can J Psychiatry 53(9):577–586
Dlabac-de Lange JJ, Knegtering R, Aleman A (2010) Repetitive transcranial magnetic stimulation for negative symptoms of schizophrenia: review and meta-analysis. J Clin Psychiatry 71(4):411–418
Grisaru N, Amir M, Cohen H, Kaplan Z (1998) Effect of transcranial magnetic stimulation in posttraumatic stress disorder: a preliminary study. Biol Psychiatry 44(1):52–55
McCann UD, Kimbrell TA, Morgan CM, Anderson T, Geraci M, Benson BE, Wassermann EM, Willis MW, Post RM (1998) Repetitive transcranial magnetic stimulation for posttraumatic stress disorder. Arch Gen Psychiatry 55(3):276–279
Rosenberg PB, Mehndiratta RB, Mehndiratta YP, Wamer A, Rosse RB, Balish M (2002) Repetitive transcranial magnetic stimulation treatment of comorbid posttraumatic stress disorder and major depression. J Neuropsychiatry Clin Neurosci 14(3): 270–276
Cohen H, Kaplan Z, Kotler M, Kouperman I, Moisa R, Grisaru N (2004) Repetitive transcranial magnetic stimulation of the right dorsolateral prefrontal cortex in posttraumatic stress disorder: a double-blind, placebo-controlled study. Am J Psychiatry 161(3): 515–524
Osuch EA, Benson BE, Luckenbaugh DA, Geraci M, Post RM, McCann U (2009) Repetitive TMS combined with exposure therapy for PTSD: a preliminary study. J Anxiety Disord 23(1):54–59
Boggio PS, Rocha M, Oliveira MO, Fecteau S, Cohen RB, Campanhã C, Ferreira-Santos E, Meleiro A, Corchs F, Zaghi S, Pascual-Leone A, Fregni F (2010) Noninvasive brain stimulation with high-frequency and low-intensity repetitive transcranial magnetic stimulation treatment for posttraumatic stress disorder. J Clin Psychiatry 71(8):992–999
Lefaucheur JP, Drouot X, Nguyen JP (2001) Interventional neurophysiology for pain control: duration of pain relief following repetitive transcranial magnetic stimulation of the motor cortex. Neurophysiol Clin 31(4): 247–252
Lefaucheur JP, Drouot X, Keravel Y, Nguyen JP (2001) Pain relief induced by repetitive transcranial magnetic stimulation of precentral cortex. Neuroreport 12(13):2963–2965
Rollnik JD, Wüstefeld S, Däuper J, Karst M, Fink M, Kossev A, Dengler R (2002) Repetitive transcranial magnetic stimulation for the treatment of chronic pain—a pilot study. Eur Neurol 48(1):6–10
Pleger B, Janssen F, Schwenkreis P, Völker B, Maier C, Tegenthoff M (2004) Repetitive transcranial magnetic stimulation of the motor cortex attenuates pain perception in complex regional pain syndrome type I. Neurosci Lett 356(2):87–90
Lefaucheur JP, Drouot X, Ménard-Lefaucheur I, Nguyen JP (2004) Neuropathic pain controlled for more than a year by monthly sessions of repetitive transcranial magnetic stimulation of the motor cortex. Neurophysiol Clin 34(2):91–95
Khedr EM, Kotb H, Kamel NF, Ahmed MA, Sadek R, Rothwell JC (2005) Longlasting antalgic effects of daily sessions of repetitive transcranial magnetic stimulation in central and peripheral neuropathic pain. J Neurol Neurosurg Psychiatry 76(6):833–838
André-Obadia N, Peyron R, Mertens P, Mauguière F, Laurent B, Garcia-Larrea L (2006) Transcranial magnetic stimulation for pain control. Double-blind study of different frequencies against placebo, and correlation with motor cortex stimulation efficacy. Clin Neurophysiol 117(7):1536–1544
Irlbacher K, Kuhnert J, Röricht S, Meyer BU, Brandt SA (2006). Central and peripheral deafferent pain: therapy with repetitive transcranial magnetic stimulation. Nervenarzt 77(10), 1196, 1198–203.
Borckardt JJ, Smith AR, Reeves ST, Madan A, Shelley N, Branham R, Nahas Z, George MS (2009) A pilot study investigating the effects of fast left prefrontal rTMS on chronic neuropathic pain. Pain Med 10(5):840–849
Mhalla A, Baudic S, Ciampi de Andrade D, Gautron M, Perrot S, Teixeira MJ, Attal N, Bouhassira D (2011) Long-term maintenance of the analgesic effects of transcranial magnetic stimulation in fibromyalgia. Pain 152(7): 1478–1485
Lefaucheur JP, Ayache SS, Sorel M, Farhat WH, Zouari HG, Ciampi de Andrade D, Ahdab R, Ménard-Lefaucheur I, Brugières P, Goujon C (2012) Analgesic effects of repetitive transcranial magnetic stimulation of the motor cortex in neuropathic pain: Influence of theta burst stimulation priming. Eur J Pain 16(10):1403–1413
Siebner HR, Rossmeier C, Mentschel C, Peinemann A, Conrad B (2000) Short-term motor improvement after sub-threshold 5-Hz repetitive transcranial magnetic stimulation of the primary motor hand area in Parkinson’s disease. J Neurol Sci 178(2):91–94
Okabe S, Ugawa Y, Kanazawa I, Effectiveness of rTMS on Parkinson’s Disease Study Group (2003) 0.2-Hz repetitive transcranial magnetic stimulation has no add-on effects as compared to a realistic sham stimulation in Parkinson’s disease. Mov Disord 18(4):382–388
Khedr EM, Farweez HM, Islam H (2003) Therapeutic effect of repetitive transcranial magnetic stimulation on motor function in Parkinson’s disease patients. Eur J Neurol 10(5):567–572
Lefaucheur JP, Drouot X, Von Raison F, Ménard-Lefaucheur I, Cesaro P, Nguyen JP (2004) Improvement of motor performance and modulation of cortical excitability by repetitive transcranial magnetic stimulation of the motor cortex in Parkinson’s disease. Clin Neurophysiol 115(11):2530–2541
Fregni F, Santos CM, Myczkowski ML, Rigolino R, Gallucci-Neto J, Barbosa ER, Valente KD, Pascual-Leone A, Marcolin MA (2004) Repetitive transcranial magnetic stimulation is as effective as fluoxetine in the treatment of depression in patients with Parkinson’s disease. J Neurol Neurosurg Psychiatry 75(8):1171–1174
Boggio PS, Fregni F, Bermpohl F, Mansur CG, Rosa M, Rumi DO, Barbosa ER, Odebrecht Rosa M, Pascual-Leone A, Rigonatti SP, Marcolin MA, Araujo Silva MT (2005) Effect of repetitive TMS and fluoxetine on cognitive function in patients with Parkinson’s disease and concurrent depression. Mov Disord 20(9):1178–1184
Lomarev MP, Kanchana S, Bara-Jimenez W, Iyer M, Wassermann EM, Hallett M (2006) Placebo-controlled study of rTMS for the treatment of Parkinson’s disease. Mov Disord 21(3):325–331
del Olmo MF, Bello O, Cudeiro J (2007) Transcranial magnetic stimulation over dorsolateral prefrontal cortex in Parkinson’s disease. Clin Neurophysiol 118(1):131–139
Arias P, Vivas J, Grieve KL, Cudeiro J (2010) Controlled trial on the effect of 10 days low-frequency repetitive transcranial magnetic stimulation (rTMS) on motor signs in Parkinson’s disease. Mov Disord 25(12): 1830–1838
Filipović SR, Rothwell JC, Bhatia K (2010) Low-frequency repetitive transcranial magnetic stimulation and off-phase motor symptoms in Parkinson’s disease. J Neurol Sci 291(1–2):1–4
Minks E, Mareček R, Pavlík T, Ovesná P, Bareš M (2011) Is the cerebellum a potential target for stimulation in Parkinson’s disease? Results of 1-Hz rTMS on upper limb motor tasks. Cerebellum 10(4):804–811
Benninger DH, Berman BD, Houdayer E, Pal N, Luckenbaugh DA, Schneider L, Miranda S, Hallett M (2011) Intermittent theta-burst transcranial magnetic stimulation for treatment of Parkinson disease. Neurology 76(7):601–609
González-García N, Armony JL, Soto J, Trejo D, Alegría MA, Drucker-Colín R (2011) Effects of rTMS on Parkinson’s disease: a longitudinal fMRI study. J Neurol 258(7):1268–1280
Khedr EM, Ahmed MA, Fathy N, Rothwell JC (2005) Therapeutic trial of repetitive transcranial magnetic stimulation after acute ischemic stroke. Neurology 65(3):466–468
Kim YH, You SH, Ko MH, Park JW, Lee KH, Jang SH, Yoo WK, Hallett M (2006) Repetitive transcranial magnetic stimulation-induced corticomotor excitability and associated motor skill acquisition in chronic stroke. Stroke 37(6):1471–1476
Khedr EM, Abdel-Fadeil MR, Farghali A, Qaid M (2009) Role of 1 and 3 Hz repetitive transcranial magnetic stimulation on motor function recovery after acute ischaemic stroke. Eur J Neurol 16(12):1323–1330
Emara TH, Moustafa RR, Elnahas NM, Elganzoury AM, Abdo TA, Mohamed SA, Eletribi MA (2010) Repetitive transcranial magnetic stimulation at 1Hz and 5Hz produces sustained improvement in motor function and disability after ischaemic stroke. Eur J Neurol 17(9):1203–1209
Talelli P, Wallace A, Dileone M, Hoad D, Cheeran B, Oliver R, Vandenbos M, Hammerbeck U, Barratt K, Gillini C, Musumeci G, Boudrias MH, Cloud GC, Ball J, Marsden JF, Ward NS, Di Lazzaro V, Greenwood RG, Rothwell JC (2012) Theta burst stimulation in the rehabilitation of the upper limb: A semirandomized, placebo-controlled trial in chronic stroke patients. Neurorehabil Neural Repair 26(8):976–987
Liepert J, Zittel S, Weiller C (2007) Improvement of dexterity by single session low-frequency repetitive transcranial magnetic stimulation over the contralesional motor cortex in acute stroke: a double-blind placebo-controlled crossover trial. Restor Neurol Neurosci 25(5–6):461–465
Nowak DA, Grefkes C, Dafotakis M, Eickhoff S, Küst J, Karbe H, Fink GR (2008) Effects of low-frequency repetitive transcranial magnetic stimulation of the contralesional primary motor cortex on movement kinematics and neural activity in subcortical stroke. Arch Neurol 65(6):741–747
Málly J, Dinya E (2007) Recovery of motor disability and spasticity in post-stroke after repetitive transcranial magnetic stimulation (rTMS). Brain Res Bull 76(4):388–395
Takeuchi N, Tada T, Toshima M, Chuma T, Matsuo Y, Ikoma K (2008) Inhibition of the unaffected motor cortex by 1 Hz repetitive transcranial magnetic stimulation enhances motor performance and training effect of the paretic hand in patients with chronic stroke. J Rehabil Med 40(4):298–303
Kakuda W, Abo M, Kobayashi K, Momosaki R, Yokoi A, Fukuda A, Umemori T (2011) Application of combined 6-Hz primed low-frequency rTMS and intensive occupational therapy for upper limb hemiparesis after stroke. NeuroRehabilitation 29(4):365–371
Kakuda W, Abo M, Shimizu M, Sasanuma J, Okamoto T, Yokoi A, Taguchi K, Mitani S, Harashima H, Urushidani N, Urashima M (2012) A multi-center study on low-frequency rTMS combined with intensive occupational therapy for upper limb hemiparesis in post-stroke patients. J Neuroeng Rehabil 9(1):4
Kleinjung T, Steffens T, Langguth B, Eichhammer P, Marienhagen J, Hajak G, Strutz J (2006) Treatment of chronic tinnitus with neuronavigated repetitive Transcranial Magnetic Stimulation (rTMS). HNO 54(6): 439–444
Londero A, Lefaucheur JP, Malinvaud D, Brugieres P, Peignard P, Nguyen JP, Avan P, Bonfils P (2006) Magnetic stimulation of the auditory cortex for disabling tinnitus: preliminary results. Presse Med 35(2 Pt 1):200–206
Langguth B, Zowe M, Landgrebe M, Sand P, Kleinjung T, Binder H, Hajak G, Eichhammer P (2006) Transcranial magnetic stimulation for the treatment of tinnitus: a new coil positioning method and first results. Brain Topogr 18(4):241–247
Plewnia C, Reimold M, Najib A, Reischl G, Plontke SK, Gerloff C (2007) Moderate therapeutic efficacy of positron emission tomography-navigated repetitive transcranial magnetic stimulation for chronic tinnitus: a randomised, controlled pilot study. J Neurol Neurosurg Psychiatry 78(2):152–156
Kleinjung T, Steffens T, Sand P, Murthum T, Hajak G, Strutz J, Langguth B, Eichhammer P (2007) Which tinnitus patients benefit from transcranial magnetic stimulation? Otolaryngol Head Neck Surg 137(4):589–595
Frank G, Kleinjung T, Landgrebe M, Vielsmeier V, Steffenhagen C, Burger J, Frank E, Vollberg G, Hajak G, Langguth B (2010) Left temporal low-frequency rTMS for the treatment of tinnitus: clinical predictors of treatment outcome—a retrospective study. Eur J Neurol 17(7):951–956
Khedr EM, Etraby AE, Hemeda M, Nasef AM, Razek AA (2010) Long-term effect of repetitive transcranial magnetic stimulation on motor function recovery after acute ischemic stroke. Acta Neurol Scand 121(1):30–37
Anders M, Dvorakova J, Rathova L, Havrankova P, Pelcova P, Vaneckova M, Jech R, Holcat M, Seidl Z, Raboch J (2010) Efficacy of repetitive transcranial magnetic stimulation for the treatment of refractory chronic tinnitus: a randomized, placebo controlled study. Neuro Endocrinol Lett 31(2):238–249
Marcondes RA, Sanchez TG, Kii MA, Ono CR, Buchpiguel CA, Langguth B, Marcolin MA (2010) Repetitive transcranial magnetic stimulation improve tinnitus in normal hearing patients: a double-blind controlled, clinical and neuroimaging outcome study. Eur J Neurol 17(1):38–44
Plewnia C, Bartels M, Gerloff C (2003) Transient suppression of tinnitus by transcranial magnetic stimulation. Ann Neurol 53(2):263–266
De Ridder D, Verstraeten E, Van der Kelen K, De Mulder G, Sunaert S, Verlooy J, Van de Heyning P, Moller A (2005) Transcranial magnetic stimulation for tinnitus: influence of tinnitus duration on stimulation parameter choice and maximal tinnitus suppression. Otol Neurotol 26(4):616–619
Fregni F, Marcondes R, Boggio PS, Marcolin MA, Rigonatti SP, Sanchez TG, Nitsche MA, Pascual-Leone A (2006) Transient tinnitus suppression induced by repetitive transcranial magnetic stimulation and transcranial direct current stimulation. Eur J Neurol 13(9):996–1001
Khedr EM, Abo-Elfetoh N, Rothwell JC, El-Atar A, Sayed E, Khalifa H (2010) Contralateral versus ipsilateral rTMS of temporoparietal cortex for the treatment of chronic unilateral tinnitus: comparative study. Eur J Neurol 17(7):976–983
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Horvath, J.C., Najib, U., Press, D. (2014). Transcranial Magnetic Stimulation (TMS) Clinical Applications: Therapeutics. In: Rotenberg, A., Horvath, J., Pascual-Leone, A. (eds) Transcranial Magnetic Stimulation. Neuromethods, vol 89. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0879-0_12
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