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Drug Self-Administration as a Model to Study the Reward System

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The Brain Reward System

Part of the book series: Neuromethods ((NM,volume 165))

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Abstract

Laboratory animals voluntarily self-administer almost all drugs of abuse humans do. Laboratory animals also develop patterns of drug-taking and seeking that are relevant to addiction. This makes drug self-administration models powerful tools to study drug-induced changes in neurobiological, psychological, and behavioral functions that are thought to contribute to the transition to addiction. We describe here the basic procedures used in drug self-administration studies carried out in laboratory animals. Mice, rats, cats, dogs, and primates used in the laboratory can self-administer drugs of abuse, but we describe methods appropriate for female and male rats, as we have long-standing expertise in carrying out such studies. Drug self-administration studies can also use the oral, inhaled, or intravenous routes to deliver drugs, but here we focus on the intravenous route, as it is the most commonly used. Thus, we describe procedures for intravenous catheter construction, catheter implantation into the jugular vein, and catheter maintenance to promote catheter patency over the course of a typical drug self-administration study. We also describe the hardware and software needed to carry out such studies. We also include visual illustrations as support for these descriptions.

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Authors and Affiliations

  1. Department of Pharmacology and Physiology, Faculty of Medicine, Groupe de recherche sur le Système Nerveux Central, Université de Montréal, Montreal, QC, Canada

    Florence Allain & Anne-Noël Samaha

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  1. Florence Allain
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  2. Anne-Noël Samaha
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Correspondence to Florence Allain or Anne-Noël Samaha .

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Editors and Affiliations

  1. Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Beirut, Lebanon

    Marc Fakhoury

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Allain, F., Samaha, AN. (2021). Drug Self-Administration as a Model to Study the Reward System. In: Fakhoury, M. (eds) The Brain Reward System. Neuromethods, vol 165. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1146-3_11

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  • DOI: https://doi.org/10.1007/978-1-0716-1146-3_11

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