Limits of Neutral Drift: Lessons From the In Vitro Evolution of Two Ribozymes Katherine L. PetrieGerald F. Joyce Original Article 26 August 2014 Pages: 75 - 90
Purine Biosynthetic Intermediate-Containing Ribose-Phosphate Polymers as Evolutionary Precursors to RNA Harold S. BernhardtRoger K. Sandwick Original Article 02 September 2014 Pages: 91 - 104
General Trends in Selectively Driven Codon Usage Biases in the Domain Archaea Andrés IriarteEugenio JaraHéctor Musto Short Review 20 September 2014 Pages: 105 - 110
Why Can’t Vertebrates Synthesize Trehalose? Juan-Carlos Argüelles Review 18 September 2014 Pages: 111 - 116
One origin for metallo-β-lactamase activity, or two? An investigation assessing a diverse set of reconstructed ancestral sequences based on a sample of phylogenetic trees Rosanna G. AldersonDaniel BarkerJohn B. O. Mitchell Original Article Open access 04 September 2014 Pages: 117 - 129
Predicting Evolutionary Site Variability from Structure in Viral Proteins: Buriedness, Packing, Flexibility, and Design Amir ShahmoradiDariya K. SydykovaClaus O. Wilke Original Article 13 September 2014 Pages: 130 - 142
Essential is Not Irreplaceable: Fitness Dynamics of Experimental E. coli RNase P RNA Heterologous Replacement Jasmine L. LovelandJocelyn RiceRobert L. Dorit Original Article 30 September 2014 Pages: 143 - 152