Abstract
Semiconductor quantum dots (SQDs) have received much attention due to their high quantum yield (QY), tunable emission spectrum, and excellent photostability. These unique optical properties endow SQDs with excellent biomedical application prospects, including biomedical imaging, drug delivery, clinical diagnosis, photodynamic therapy, DNA hybridization, and RNA profiling. This review introduces the classification of QDs and provides a brief description of the characteristics of QDs under each classification. Taking the type II B-VI A QDs as an example, inorganic and organic modification methods, and the corresponding advantages and disadvantages are summarized and discussed. Controlled modification approaches make them exhibit different functions in the bioimaging and drug delivery fields. The typical or classic instances are also listed to present the highlights of the applications of SQDs in the biomedical field. Based on these, this review raises a variety of possible challenges and perspectives of SQDs in biomedical applications in the future.
摘要
半导体量子点由于其高量子产率、 可调谐的发射光谱和优异的光稳定性而受到人们的广泛关注. 这些独特的光学特性赋予半导体量子点在生物医学领域中出色的应用前景, 譬如量子点可在生物医学成像、 药物输送、 临床诊断、光动力疗法、 DNA杂交和RNA分析等领域中得以应用. 本综述介绍了量子点的分类, 并简要描述了每类量子点的特征. 以II B-VI A型量子点为例, 分别讨论和总结了其无机和有机修饰方法及相应的优缺点. 基于可控的修饰方法, 量子点在生物成像和药物传递领域表现出不同的功能. 本文还列出了量子点的一些典型或经典实例, 用于介绍半导体量子点在生物医学领域中的应用亮点. 以此为基础, 本综述提出了半导体量子点在未来生物医学领域中的各种潜在挑战和应用前景.
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Acknowledgements
This work was supported by the National Natural Science Foundation of China (61875138, 61435010 and 6181101252), the Science and Technology Innovation Commission of Shenzhen (KQTD2015032416270385, JCYJ20150625103619275 and JCYJ20170811093453105), and China Postdoctoral Science Foundation (2019M663062). The authors also acknowledge the support from the Instrumental Analysis Center of Shenzhen University (Xili Campus).
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Author contributions Wang L is responsible for designing the writing framework and full-text writing. Xu D and Gao J are responsible for the literature search and organization of the third part. Duo Y is responsible for the literature search and arrangement of the fourth part. Chen X and Zhang H are responsible for the review of the full text.
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Lude Wang received her PhD degree from the Southeast University. Currently, she works as a postdoctoral researcher at the International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, Institute of Microscale Optoelectronics, Shenzhen University, China. Her research interests focus on functional materials and their applications in the fields of biomedical science and sensing.
Xiang Chen got his PhD degree from the University of Science and Technology Beijing. Then, he worked as a research professor in the School of Electrical and Electronic Engineering, Yonsei University. In 2018, he joined the School of Materials Science and Engineering, Nanjing University of Science and Technology (NJUST), as a professor. His research interests are the controllable and wafer-scale synthesis of 2D semiconducting materials and their applications in integrated, flexible, and bioabsorbable electronics.
Yanhong Duo received her PhD degree from the Department of Life Sciences at Lanzhou University and the Department of Division of Life and Health Sciences at Tsinghua University in 2017 (Joint training). Currently she is a postdoctoral in the Department of Microbiology, Tumor and Cell Biology, Karolinska Institute. Her current research interests focus on 2D material-based theranostic nanoplatforms for biomedical applications.
Han Zhang is a full Professor and Director of Shenzhen Engineering Laboratory of Phosphorene and Optoelectronics, Shenzhen University. He is an expert on low-dimensional optoelectronic devices and applications. Most of his publications are correlated to the photonic and optoelectronic applications of 2D nanomaterials especially graphene, transition metal dichalcogenides and black phosphorus. He has been awarded as highly cited researcher by Clarivate Analytics at 2018 and 2019, and OSA fellow.
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Wang, L., Xu, D., Gao, J. et al. Semiconducting quantum dots: Modification and applications in biomedical science. Sci. China Mater. 63, 1631–1650 (2020). https://doi.org/10.1007/s40843-020-1330-7
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DOI: https://doi.org/10.1007/s40843-020-1330-7