Abstract
Luminescent bioassay techniques have been widely adopted in a variety of research and medical institutions. However, conventional luminescent bioassays utilizing traditional bioprobes like organic dyes and quantum dots often suffer from the interference of background noise from scattered lights and autofluorescence from biological matrices. To eliminate this disadvantage, the use of inorganic lanthanide (Ln3+)-doped nanoparticles (NPs) is an excellent option in view of their superior optical properties, such as the long-lived downshifting luminescence, near-infrared triggered anti-Stokes upconverting luminescence and excitation-free persistent luminescence. In this review, we summarize the latest advances in the development of inorganic Ln3+-doped NPs as sensitive luminescent bioprobes from their fundamental physicochemical properties to biodetection, including the chemical synthesis, surface functionalization, optical properties and their promising applications for back-ground-free luminescent bioassays. Future efforts and prospects towards this rapidly growing field are also proposed.
摘要
荧光生物分析技术在科研及医疗机构已获得广泛应用. 常规的荧光免疫分析方法由于采用传统生物探针(如荧光染料及量子点等)作为标记, 易受到杂散光及生物组织自荧光的干扰. 利用无机稀土纳米荧光探针优异的发光性能, 如长荧光寿命的下转移发光、 近红外激发的上转换发光以及无需激发源的长余辉发光, 可有效解决背景荧光的干扰. 本文从基础的物理化学性能到生物应用角度出发综述了无机稀土纳米发光材料的最新进展, 包括材料的控制合成、 表面功能化、 光学性能及其在无背景荧光生物分析方面的应用示范, 并对该类材料未来的发展趋势与努力的方向作了进一步的远景展望.
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Ping Huang was born in Hebei, China. She received her BSc degree (2008) from Hebei University. She received her PhD (2014) in materials physics and chemistry from Fujian Institute of Research on the Structure of Matter (FJIRSM), CAS. She joined Prof. Xueyuan Chen’s group as a research assistant professor in July 2014. Her research interest focuses on the chemical synthesis, optical spectroscopy and bioapplications of lanthanide-doped nanoprobes.
Xueyuan Chen received his BSc degree from University of Science and Technology of China (1993) and his PhD degree from FJIRSM, CAS (1998). From 2001 to 2005, he was a postdoctoral research associate at the Chemistry Division of Argonne National Laboratory, Department of Energy of USA, where he studied the photophysics and photochemistry of heavy elements. In 2005, he joined the FJIRSM, where he is currently a professor and group leader in material chemistry and physics. His research focuses on the chemistry, optical spectroscopy and bioapplications of lanthanide-doped luminescent nanomaterials.
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Huang, P., Tu, D., Zheng, W. et al. Inorganic lanthanide nanoprobes for background-free luminescent bioassays. Sci. China Mater. 58, 156–177 (2015). https://doi.org/10.1007/s40843-015-0019-4
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DOI: https://doi.org/10.1007/s40843-015-0019-4