Abstract
Gallic acid(GA) is a kind of natural polyphenolic compound, but its low aqueous solubility restricts its application in the fields of food and medicine. Cyclodextrin can form inclusion complexes with guest molecules(e.g., essential oils, food supplements) through cavities with special properties to improve aqueous solubility, thermal stability, and bioavailability of guest molecules. In this research, gallic acid/2-hydroxypropyl-β-cyclodextrin inclusion complexes(GA/2-HP-β-CD/ICs) were formed in a highly concentrated solution of 2-HP-β-CD. Bead-free and uniform nanofibrous webs(GA/2-HP-β-CD/IC-NWs) were produced successfully by electrospun GA/HP-β-CD/IC aqueous solution. The initial molar ratio(GA: 2-HP-β-CD=1:1) of GA/2-HP-β-CD/IC in the solutions was largely maintained in GA/2-HP-β-CD/IC-NW. The aqueous solubility of GA was enhanced and GA/2-HP-β-CD/IC-NW has displayed fast dissolution property. Furthermore, in comparison with GA powder, GA/2-HP-β-CD/IC-NW demonstrated improved antioxidant capacity. The results suggested that GA/2-HP-β-CD/IC-NW have broad application prospects as orally fast dissolution systems for food supplements.
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References
Choubey S., Varughese L. R., Kumar V., Beniwal V., Pharm. Pat. Anal., 2015, 4, 305
Daneshfar A., Ghaziaskar H. S., Homayoun N., J. Chem. Eng. Data, 2008, 53, 776
Noubigh A., Jeribi C., Mgaidi A., Abderrabba M., J. Chem. Thermodyn., 2012, 55, 75
Kurkov S. V., Loftsson T., Int. J. Pharm., 2013, 453, 167
Topuz F., Uyar T., Pharmaceutics, 2019, 11, 6
Zhang J., Ma P. X., Adv. Drug Delivery Rev., 2013, 65, 1215
Celebioglu A., Uyar T., J. Agric. Food Chem., 2019, 67, 13093
Pinho E., Grootveld M., Soares G., Henriques M., Carbohydr. Polym., 2014, 101, 121
Celebioglu A., Uyar T., Food Chem., 2020, 317, 126397
Celebioglu A., Yildiz Z. I., Uyar T., J. Agric. Food Chem., 2018, 66, 457
Yildiz Z. I., Celebioglu A., Kilic M. E., Durgun E., Uyar T., J. Food Eng., 2018, 224, 27
Zhang C., Li Y., Wang P., Zhang H., Compr. Rev. Food Sci. Food Saf., 2020, 19, 479
Ghorani B., Tucker N., Food Hydrocolloids, 2015, 51, 227
Deng L., Taxipalati M., Zhang A., Que F., We H., Feng F., Zhang H., J. Agric. Food Chem., 2018, 66, 6219
Alejandra Moreno M., Eugenia Orqueda M., Gomez-Mascaraque L. G., Ines Isla M., Lopez-Rubio A., Food Hydrocolloids, 2019, 95, 496
Li H., Wang M., Williams G. R., Wu J., Sun X., Lv Y., Zhu L.-M., RSC Adv., 2016, 6, 50267
Feng K., Huang R.-M., Wu R.-Q., Wei Y.-S., Zong M.-H., Linhardt R. J., Wu H., Food Chem., 2020, 310, 125977
Wen P., Wen Y., Zong M.-H., Linhardt R. J., Wu H., J. Agric. Food Chem., 2017, 65, 9161
Yildiz Z. I., Kilic M. E., Durgun E., Uyar T., J. Agric. Food Chem., 2019, 67, 11066
Aytac Z., Kusku S. I., Durgun E., Uyar T., Mat. Sci. Eng. C: Mater., 2016, 63, 231
Wutticharoenmongkol P., Hannirojram P., Nuthong P., Polym. Adv. Technol., 2019, 30, 1135
Celebioglu A., Uyar T., Mol. Pharmaceutics, 2019, 16, 4387
Aydogdu A., Yildiz E., Aydogdu Y., Sumnu G., Sahin S., Ayhan Z., Food Hydrocolloids, 2019, 95, 245
Yildiz Z. I., Celebioglu A., Kilic M. E., Durgun E., Uyar T., J. Mater. Sci., 2018, 53, 15837
Aydogdu A., Sumnu G., Sahin S., Carbohydr. Polym., 2019, 208, 241
Chunshom N., Chuysinuan P., Thanyacharoen T., Techasakul S., Ummartyotin S., Mater. Chem. Phys., 2019, 232, 294
Neo Y. P., Ray S., Jin J., Gizdavic-Nikolaidis M., Nieuwoudt M. K., Liu D., Quek S. Y., Food Chem., 2013, 136, 1013
Liu Z., Ren Z., Zhang J., Chuang C.-C., Kandaswamy E., Zhou T., Zuo L., Front. Physiol., 2018, 9, 477
Roidoung S., Dolan K. D., Siddiq M., Food Chem., 2016, 210, 422
Bi Y., Sunada H., Yonezawa Y., Danjo K., Otsuka A., Iida K., Chem. Pharm. Bull., 1996, 44, 212
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This work was supported by the Project of the Jilin Province Development and Reform Commission, China(No.2020C023-5) and the National Natural Science Foundation of China(No.31772058).
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Gallic acid/2-hydroxypropyl-β-cyclodextrin inclusion complexes electrospun nanofibrous webs: Fast dissolution, improved aqueous solubility and antioxidant property of gallic acid
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Song, Y., Huang, H., He, D. et al. Gallic Acid/2-Hydroxypropyl-β-cyclodextrin Inclusion Complexes Electrospun Nanofibrous Webs: Fast Dissolution, Improved Aqueous Solubility and Antioxidant Property of Gallic Acid. Chem. Res. Chin. Univ. 37, 450–455 (2021). https://doi.org/10.1007/s40242-021-0014-0
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DOI: https://doi.org/10.1007/s40242-021-0014-0