Abstract
Total knee arthroplasty (TKA) is the gold standard of treatment for advanced osteoarthritis of the knee. The technical methods of cartilage regeneration procedures are now well-developed. Indications for this procedure are being expanded to the treatment of osteoarthritis. We compared data from 42 patients who underwent TKA and from 52 patients who underwent MCIC (autologous bone marrow mesenchymal-cell-induced-chondrogenesis). All patients were over 50 years of age and showed grade IV of the Kellgren-Lawrence classification. The TKA patients were older and predominantly female, compared to the MCIC patients. There was no difference between the two groups regarding the patient satisfaction. Clinical evaluation of the two groups showed significant mean improvement in the tKSS-A (pain) and tKSS-B (function) scores throughout the postoperative follow-up period. The monetary cost of TKA was relatively higher than that of MCIC. Therefore, considering the patient age and quality of life, MCIC is a potential treatment option for osteoarthritis as it thus delays the disease progression.
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Bonneux L, Barendregt JJ, Van der Maas PJ, The expiry date of man: a synthesis of evolutionary biology and public health, J Epidemiol Community Health, 52, 619 (1998).
Odole AC, Ojo OD, Is telephysiotherapy an option for improved quality of life in patients with osteoarthritis of the knee?, Int J Telemed Appl, (2014).
Kurtz S, Ong K, Lau E, et al., Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030, J Bone Joint Surg Am, 89, 780 (2007).
Anders S, Volz M, Frick H, Gellissen J, A Randomized, Controlled Trial Comparing Autologous Matrix-Induced Chondrogenesis (AMIC®) to Microfracture: Analysis of 1- and 2-Year Follow-Up Data of 2 Centers, Open Orthop J, 3, 133 (2013).
Rodriguez-Merchan EC, Regeneration of articular cartilage of the knee, Rheumatol Int, 33, 837(2012).
Kim KT, Lee S, Ko DO, et al., Causes of failure after total knee arthroplasty in osteoarthritis patients 55 years of age or younger, Knee Surg Relat Res, 26, 13 (2014).
Aggarwal VK, Goyal N, Deirmengian G, et al., Revision total knee arthroplasty in the young patient: is there trouble on the horizon?, J Bone Joint Surg Am, 96, 536 (2014).
Shetty AA, Kim SJ, Bilagi P, et al., Autologous collageninduced chondrogenesis: single-stage arthroscopic cartilage repair technique, Orthopedics, 36, e648 (2013).
JD Jang, YS Moon, YS Kim, NY Choi, et al., Novel Repair Technique for Articular Cartilage Defect Using a Fibrin and Hyaluronic Acid Mixture. Tissue Engineering and Regenerative Medicine, 10, 1 (2013).
AA Shetty, SJ Kim, V Shetty, D Stelzeneder, N Shetty, P Bilagi., Autologous bone-marrow mesenchymal cell induced chondrogenesis: Single-stage arthroscopic cartilage repair. Tissue Engineering and Regenerative Medicine, 11, 247 (2014).
Vazquez-Vela Johnson G, Worland RL, Keenan J, et al., Patient demographics as a predictor of the ten-year survival rate in primary total knee replacement. J Bone Joint Surg Br, 85, 52 (2003).
Ishijima M, Nakamura T, Shimizu K, et al., Intra-articular hyaluronic acid injection versus oral non-steroidal antiinflammatory drug for the treatment of knee osteoarthritis: a multi-center, randomized, open-label, non-inferiority trial, Arthritis Res Ther, 16, R18 (2014).
Steadman JR, Briggs KK, Rodrigo JJ, et al., Outcomes of microfracture for traumatic chondral defects of the knee: average 11-year follow-up, Arthroscopy, 19, 477 (2003).
LØken S, Heir S, Holme I, et al., 6-year follow-up of 84 patients with cartilage defects in the knee. Knee scores improved but recovery was incomplete, Acta Orthop, 85, 611 (2010).
SchrØder HM, Berthelsen A, Hassani G, et al., Cementless porous-coated total knee arthroplasty: 10-year results in a consecutive series, J Arthroplasty, 16, 559 (2001).
Robertsson O, Dunbar M, Pehrsson T, et al., Patient satisfaction after knee arthroplasty: a report on 27,372 knees operated on between 1981 and 1995 in Sweden, Acta Orthop Scand, 71, 262 (2000).
Kuster MS, Bitschnau B, Votruba T, Influence of collateral ligament laxity on patient satisfaction after total knee arthroplasty: a comparative bilateral study, Arch Orthop Trauma Surg. 124, 415 (2004).
Conteduca F, Iorio R, Mazza D, et al., Patient-specific instruments in total knee arthroplasty, Int Orthop, 38, 259 (2014).
Bullens PH, van Loon CJ, de Waal Malefijt MC, et al., Patient satisfaction after total knee arthroplasty: a comparison between subjective and objective outcome assessments, Arthroplasty, 16, 740 (2001).
Ali A, Sundberg M, Robertsson O, et al., Dissatisfied patients after total knee arthroplasty, Acta Orthop, 30, (2014).
Koh IJ, Cho WS, Choi NY, et al., Causes, risk factors, and trends in failures after TKA in Korea over the past 5 years: a multicenter study, Clin Orthop Relat Res, 472, 316 (2014).
Steadman JR, Briggs KK, Rodrigo JJ, et al., Outcomes of microfracture for traumatic chondral defects of the knee: average 11-year follow-up, Arthroscopy, 19, 477 (2003).
Mithoefer K, McAdams T, Williams RJ, et al., Clinical efficacy of the microfracture technique for articular cartilage repair in the knee: an evidence-based systematic analysis, Am J Sports Med, 37, 2053 (2009).
Bae DK, Song SJ, Yoon KH, et al., Survival analysis of microfracture in the osteoarthritic knee-minimum 10-year followup, Arthroscopy, 29, 244 (2013).
Enea D, Cecconi S, Calcagno S, et al., Single-stage cartilage repair in the knee with microfracture covered with a resorbable polymer-based matrix and autologous bone marrow concentrate, Knee, 20, 562 (2013).
Strauss E, Schachter A, Frenkel S, et al., The efficacy of intraarticular hyaluronan injection after the microfracture technique for the treatment of articular cartilage lesions, Am J Sports Med, 37, 720 (2009).
Katkhouda N, Friedlander M, Darehzereshki A, et al., Argon beam coagulation versus fibrin sealant for hemostasis following liver resection: a randomized study in a porcine model, Hepatogastroenterology, 60, 1110 (2013).
Schnurr C, Jarrous M, Güdden I, et al., Pre-operative arthritis severity as a predictor for total knee arthroplasty patients’ satisfaction, Int Orthop, 37, 1257 (2013).
Chang CB, Yoo JH, Koh IJ, et al., Key factors in determining surgical timing of total knee arthroplasty in osteoarthritic patients: age, radiographic severity, and symptomatic severity, J Orthop Traumatol, 11, 21 (2010).
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Kim, J.M., Han, J.R., Shetty, A.A. et al. Comparison between total knee arthroplasty and MCIC (autologous bone marrow mesenchymal-cell-induced-chondrogenesis) for the treatment of osteoarthritis of the knee. Tissue Eng Regen Med 11, 405–413 (2014). https://doi.org/10.1007/s13770-014-0041-8
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DOI: https://doi.org/10.1007/s13770-014-0041-8