Biliary atresia has been commonly reported with cytomegalovirus (CMV) infection. CMV positive patients may present with a later onset however long term outcome is similar to non-CMV patients. There are very few case reports of role of antivirals in CMV and biliary atresia. We treated a 2 month old girl with biliary atresia who underwent portoduodenostomy at 2½ months of age but continued to have jaundice (bilirubin = 23.6 mg/dl) even after 1 month of Kasai’s surgery and subsequently was treated with valganciclovir for 6 weeks following which her jaundice resolved.
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Zukotynski K, Babyn PS. Biliary Atresia. Available from: http://www.emedicine.com. Accessed on 5 February, 2010.
Fischler B, Svensson JF, Nemeth A. Early cytomegalovirus infection and the long-term outcome of biliary atresia. Acta Paediatr. 2009;98:1600–1602.
Rauschenfels S, Krassmann M, Al-Masri AN, Verhagen W, Leonhardt J, Kuebler JF, et al. Incidence of hepatotropic viruses in biliary atresia. Eur J Pediatr. 2009;168:469–476.
Sanghai S, Shah I, Bhatnagar S, Murthy A. incidence and prognostic factors associated with biliary atresia in western India. Annals Hepatol. 2009;8:120–122.
Miiler A, Eis-Hubinger AM, Brandhorst G, Heep A, Bartmann P, Franz AR. Oral valganciclovir for symptomatic congenital cytomegalovirus infection in an extremely low birth weight infant. J Perinatol. 2008;28:74–76.
Fischler B, Casswall TH, Malmborg P, Nemeth A. Ganciclovir treatment in infants with cytomegalovirus infection and cholestasis. J Pediatr Gastroenterol Nutr. 2002;34:154–157.
Tezer H, Secmeer G, Kara A, Ceyhan M, Cengiz AB, Devrim I, et al. Cytomegalovirus hepatitis and ganciclovir treatment in immunocompetent children. Turk J Pediatr. 2008;50:228–234.
Fischler B, Wozenius S, Nemeth A, Papadogiannakis N. Immunoglobulin deposits in liver tissue from infants with biliary atresia and the correlation to cytomegalovirus infection. J Pediatr Surg. 2005;40:541–546.
Ozkan TB, Mistik R, Dikici B, Nazlioglu HD. Antiviral therapy in neonatal cholestatic cytomegalovirus hepatitis. BMC Gastroenterol. 2007;7:9.
Chang MH, Huang HH, Huang ES, Kao CL, Hsu HY, Lee CY. Polymerase chain reaction to detect human cytomegalovirus in livers of infants with neonatal hepatitis. Gastroenterology. 1992;103:1022–1025.
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Shah, I., Bhatnagar, S. Biliary Atresia and Cytomegalovirus and Response to Valganciclovir. Indian Pediatr 49, 484–486 (2012). https://doi.org/10.1007/s13312-012-0092-7
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DOI: https://doi.org/10.1007/s13312-012-0092-7