Abstract
Objective
To assess whether quick cognitive screening test (QCST) could quickly identify mild cognitive impairment (MCI).
Methods
QCST and a full set of standardized neuropsychological tests, including mini-mental state examination (MMSE) and montreal cognitive assessment (MoCA) were performed. A total number of 121 cases of MCI [41 cases of amnestic MCI-single domain (aMCI-s); 44 of amnestic MCI-multiple domain (aMCI-m); 36 of nonamnestic MCI (naMCI)], 79 cases of mild Alzheimer’s disease (AD) and 186 healthy elderly volunteers were employed in the present study. All the participants (55–85 years old) had an educational level no less than 5 years. QCST subtests included word list recall, naming test, animal fluency test, similarity test, color trail-1min, clock drawing test, finger construction test, and digit span test. The total score of QCST was 90 points, 10 points for each index of subtests.
Results
The total scores of QCST in MCI, AD and the control groups were (58.13±8.18), (44.53±10.54) and (72.92±6.85) points, respectively. According to the educational level, the cut off scores of participants with an educational level of 5–8 years, 9–12 years and more than 13 years were 63, 65 and 68 points, respectively. The sensitivity and specificity of QCST in detection of MCI were 87.6% (85.7% for aMCI-s, 90.1% for aMCI-m and 89.5% for naMCI) and 84.3%, respectively. The area under the curve was 0.923 (95% CI: 0.892–0.953). Delayed memory, color trail-1min and similarity test could help distinguish between aMCI and naMCI.
Conclusion
QCST may have a good sensitivity and specificity for MCI detection, which warrants its further clinical application.
摘要
目的
轻度认知损害(mild cognitive impairment, MCI)可根据认知表现分为遗忘型 MCI (aMCI)和非遗忘型MCI(naMCI)。 本研究旨在编制快速认知筛查测验(quick cognitive screening test, QCST)便于快速全面地识别MCI, 为进一步研究提供依据。
方法
符合 MCI 操作性诊断标准的MCI 组121 例、 符合DSM-IV有关痴呆诊断标准的阿尔茨海默病(AD)组79 例和正常老年人组186 例, 参与了QCST 和标准化全套神经心理测验。 参与者教育程度均在5 年或以上, 年龄55–85 岁。 QCST 项目包括即刻记忆、 延迟回忆、 命名、 动物流畅性、 相似性、 彩色连线B、 画钟、 手指结构、 数字广度等9 个分测验, 每个分测验满分10 分, 总分90 分, 耗时10–15 分钟。
结果
MCI 组、 AD组和正常老年人组QCST总分分别为(58.13±8.18)、 (44.53±10.54)和(72.92±6.85)分。 制定教育程度在5–8年、 9–12 年、 高于13 年3 个组别的QCST 总分的划界分分别为63、 65 和68 分。 QCST 识别 MCI 的敏感性为87.6%, 其中识别aMCI-s、 aMCI-m 和naMCI 的敏感性分别为85.7%、 90.1% 和89.5%, 特异性均为84.3%。 曲线下面积为0.923 (95% CI: 0.892–0.953)。 延迟回忆、 连线和相似性均有助于区分aMCI 与naMCI。
结论
QCST 对MCI 具有较高的敏感性和特异性, 可在临床和流行病学调查方面进行推广应用。
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References
Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 1999, 56(3): 303–308.
Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund LO, et al. Mild cognitive impairment-beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med 2004, 256: 240–246.
Portet F, Ousset PJ, Visser PJ, Frisoni GB, Nobili F, Scheltens P, et al. Mild cognitive impairment (MCI) in medical practice: a critical review of the concept and new diagnostic procedure. Report of the MCI Working Group of the European Consortium on Alzheimer’s Disease. J Neurol Neurosurg Psychiatry 2006, 77(6):714–718.
Jungwirth S, Weissgram S, Zehetmayer S, Tragl KH, Fischer P. VITA: subtypes of mild cognitive impairment in a communitybased cohort at the age of 75 years. Int J Geriatr Psychiatry 2005, 20(5): 452–458.
Fischer P, Jungwirth S, Zehetmayer S, Weissgram S, Hoenigschnabl S, Gelpi E, et al. Conversion from subtypes of mild cognitive impairment to Alzheimer dementia. Neurology 2007, 68: 288–291.
Busse A, Hensel A, Gühne U, Angermeyer MC, Riedel-Heller SG. Mild cognitive impairment: long-term course of four clinical subtypes. Neurology 2006, 67(12): 2176–2185.
Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med 2004, 256(3): 183–194.
Molloy DW, Standish TI, Lewis DL. Screening for mild cognitive impairment: comparing the SMMSE and the ABCS. Can J Psychiatry 2005, 50(1): 52–58.
Rami L, Molinuevo JL, Sanchez-Valle R, Bosch B, Villar A. Screening for amnestic mild cognitive impairment and early Alzheimer’s disease with M@T (Memory Alteration Test) in the primary care population. Int J Geriatr Psychiatry 2007, 22(4): 294–304.
Flaks MK, Yassuda MS, Regina AC, Cid CG, Camargo CH, Gattaz WF, et al. The Short Cognitive Performance Test (SKT): a preliminary study of its psychometric properties in Brazil. Int Psychogeriatr 2006, 18(1): 121–133.
Nasreddine ZS, Phillips NA, B’edirian V, Charbonneau S, Whitehead V, Collin I, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 2005, 53(4): 695–699.
Tang-Wai DF, Knopman DS, Geda YE, Edland SD, Smith GE, Ivnik RJ, et al. Comparison of the short test of mental status and the mini-mental state examination in mild cognitive impairment. Arch Neurol 2003, 60(12): 1777–1781.
Roth M, Tym E, Mountjoy CQ, Huppert FA, Hendrie H, Verma S, et al. CAMDEX: A standardized instrument for the diagnosis of mental disorders in the elderly with special reference to early detection of dementia. Br J Psychiatry 1986, 149: 698–709.
Nunes PV, Diniz BS, Radanovic M, Abreu ID, Borelli DT, Yassuda MS, et al. CAMcog as a screening tool for diagnosis of mild cognitive impairment and dementia in a Brazilian clinical sample of moderate to high education. Int J Geriatr Psychiatry 2008, 23(11): 1127–1133.
Kalbe E, Kessler J, Calabrese P, Hilker R, Riedel O, Wittchen HU, et al. DemTect: A new, sensitive cognitive screening test to support the diagnosis of mild cognitive impairment and early dementia. Int J Geriatr Psychiatry 2004, 19: 136–143.
Solomon PR, Hirschoff A, Kelly B, Relin M, Brush M, DeVeaux RD, et al. A 7 minute neurocognitive screening battery highly sensitive to Alzheimer’s disease. Arch Neurol 1998, 55: 349–355.
Petersen RC, Doody R, Kurz A, Mohs RC, Morris JC, Rabins PV, et al. Current concepts in mild cognitive impairment. Arch Neurol 2001, 58(12): 1985–1992.
Guo QH, Zhao Q, Chen M, Ding D, Hong Z. A comparison study on mild cognitive impairment with 3 memory tests among Chinese individuals. Alzheimer Dis Assoc Disord 2009, 23(3): 253–259.
Katzman RC, Zhanga YM, Qua OY, Wang ZY, Liu WT, Yu E, et al. A Chinese version of the mini-mental state examination; Impact of illiteracy in a Shanghai dementia survey. J Clin Epidemiol 1988, 41(10): 971–978.
Diagnostic and statistical mannual of mental disorders. 4th Ed. Washington, DC: American Psychiatric Association, 1994.
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer’s disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 1984, 34: 939–944.
Guo QH, Hong Z, Shi WX, Lu CZ. Boston naming test using by Chinese elderly, patient with mild cognitive impairment and Alzheimer’s dementia. Chinese Mental Health Journal 2006, 20(2): 81–85.
Zhao QH, Guo QH, Shi WX, Hong Z. Category verbal fluency test in identification and differential diagnosis of dementia. Chin J Clin Psychol 2007, 3: 241–245.
Lin KN, Wang PN, Liu CY, Chen WT, Lee YC, Liu HC. Cutoff scores of the cognitive abilities screening instrument, Chinese version in screening of dementia. Dement Geriatr Cogn Disord 2002, 14: 176–182.
Lee TM, Chan CC. Are trail making and color trails tests of equivalent constructs? J Clin Exp Neuropsychol 2000, 22(4): 529–534.
Guo QH, Fu JH, Yuan J, Zhao Q, Cao XY, Hong Z. A study of validity of a new scoring system of clock drawing test. Chin J Neurol 2008, 41(4): 234–237.
Gong YX. Chinese version of the Wechsler Adult Intelligence Scale (WAIS-RC). Hunan Maping Press, 1992.
Guo QH, Hong Z, Lu CZ. Clinical validity of the Chinese version of Mattis Dementia Rating Scale in differentiating dementia of Alzheimer type in Shanghai. Chin J Clin Psychol 2004, 12(3): 237–243.
Nasreddine ZS, Phillips NA, B’edirian V, Charbonneau S, Whitehead V, Collin I, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 2005, 53(4): 695–699.
Yu H, Guo QH, Hong Z, Lu CZ. Detecting of logical memory impairment in mild Alzheimer’s disease. Nerv Dis Ment Hyg 2005, 5(2): 89–91.
Guo QH, Lv CZ, Hong Z, Lu CZ. Application of Rey-Osterrieth Complex Figure Test in Chinese normal old people. Chin J Clin Psychol 2000, 8(4): 205–207.
Guo QH, Sun YM, Yuan J, Hong Z, Lu CZ. Application of eight executive tests in participants at Shanghai communities. Chin J Behavioral Med Sci 2007, 16(7): 628–631.
Perneczky R, Pohl C, Sorg C, Hartmann J, Komossa K, Alexopoulos P, et al. Complex activities of daily living in mild cognitive impairment: conceptual and diagnostic issues. Age Ageing 2006, 35(3): 240–245.
Morris JC. The clinical dementia rating (CDR): current version and scoring rules. Neurology 1993, 43(11): 2412–2414.
Bozoki A, Giordani B, Heidebrink JL, Berent S, Foster NL. Mild cognitive impairments predicts dementia in nondemented elderly patients with memory loss. Arch Neurol 2001, 58: 411–416.
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Guo, QH., Cao, XY., Zhou, Y. et al. Application study of quick cognitive screening test in identifying mild cognitive impairment. Neurosci. Bull. 26, 47–54 (2010). https://doi.org/10.1007/s12264-010-0816-4
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DOI: https://doi.org/10.1007/s12264-010-0816-4