Abstract
Currently two mechanisms are recognized by which heat shock proteins (HSP) are released from cells; a passive release mechanism, including necrotic cell death, severe blunt trauma, surgery and following infection with lytic viruses, and an active release mechanism which involves the non classical protein release pathway. HSPs are released both as free HSP and within exosomes. This review covers recent findings on the mechanism by which stress induces the release of HSP72 into the circulation and the biological significance of circulating HSP72 to host defense against disease.
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Abbreviations
- APC:
-
antigen presenting cells
- eHSP72:
-
extracellular HSP72
- Hsc73:
-
constitutive seventy-kilo Dalton heat shock protein
- HSP72:
-
inducible seventy-kilo Dalton heat shock protein
- IFN-γ:
-
interferon-gamma
- iHSP72:
-
intracellular HSP72
- TLR:
-
toll-like receptors
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Asea, A. Mechanisms of HSP72 release. J Biosci 32, 579–584 (2007). https://doi.org/10.1007/s12038-007-0057-5
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DOI: https://doi.org/10.1007/s12038-007-0057-5