Abstract
Although tension-type headache is the most frequent primary headache, little is known about its pathophysiology. It is a matter of debate if the pain in tension-type headache originates from myofascial tissues or from central mechanisms in the brain. This article presents a summary of available data on the pathophysiology of tension-type headache and proposes a pathogenic model. From experimental research and clinical studies, it appears that myofascial nociception is important in episodic tension-type headache; however, central mechanisms (ie, central sensitization) are preponderant in the pathophysiology of the chronic form. Understanding the mechanisms of this central sensitization could allow for more efficient prophylactic treatments to emerge.
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Vandenheede, M., Schoenen, J. Central mechanisms in tension-type headaches. Current Science Inc 6, 392–400 (2002). https://doi.org/10.1007/s11916-002-0082-x
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DOI: https://doi.org/10.1007/s11916-002-0082-x