Abstract
In this paper, a new synchronization problem for the collective dynamics among genetic oscillators with unbounded time-varying delay is investigated. The dynamical system under consideration consists of an array of linearly coupled identical genetic oscillators with each oscillators having unbounded time-delays. A new concept called power-rate synchronization, which is different from both the asymptotical synchronization and the exponential synchronization, is put forward to facilitate handling the unbounded time-varying delays. By using a combination of the Lyapunov functional method, matrix inequality techniques and properties of Kronecker product, we derive several sufficient conditions that ensure the coupled genetic oscillators to be power-rate synchronized. The criteria obtained in this paper are in the form of matrix inequalities. Illustrative example is presented to show the effectiveness of the obtained results.
Similar content being viewed by others
Explore related subjects
Discover the latest articles, news and stories from top researchers in related subjects.Avoid common mistakes on your manuscript.
Introduction
It is well known that gene expression is a complex process regulated at several stages in the synthesis of proteins (Lewin 1999). DNA microarray technology has made it possible to measure gene expression levels on a genomic scale, and has therefore been widely applied to gene transcription analysis (Fraser et al. 2004). With the available huge amount of microarray data, researchers have been trying to understand how biological activities are governed by the connectivity of genes and proteins, which is described in terms of genetic regulatory networks (GRNs). A gene network consists of a group of genes that interact among themselves in order to synthesize certain products, i.e., proteins. The types and amount of proteins produced by a gene network have a fundamental effect on the development of the gene network itself, and on the biological systems with which the network interacts. Since genetic networks are biochemical dynamical systems, mathematical modelling of genetic networks as dynamical system models provides a powerful tool for studying gene regulation processes in living organisms (Wang et al. 2008). The study of genetic regulatory networks have become an attractive area and received great attention over past decade (Li et al. 2006a, b; Ren and Cao 2008; Wang et al. 2010; Xiao et al. 2014; Cao and Ren 2008; Ren et al. 2015).
Synchronization is an important dynamical behavior that has been intensively investigated in the last decade (Wu and Chua 1995; Li and Chen 2004; Lu and Chen 2004; Wang and Cao 2006; Li et al. 2014; Huang et al. 2008; Qiu and Cao 2009). There are many benefits of having synchronization in some applications, such as secure communication, human heartbeat regulation, chemical reaction, power systems protection, ecological systems and so on. Recently, it has been discovered that the phase synchronization can also exist in many biologically plausible systems and such synchronization is a main mechanism to fulfil cellular communication. Therefore, it is not surprising that the synchronization problem of coupled genetic oscillators has begun to attract a great deal of research attention due to its potential applications in GRNs. For example, in McMillen et al. (2002), Kuznetsov et al. (2004), and Wang and Chen (2005), the synchronization was studied in biological networks of identical genetic oscillators and, in Garcia-Ojalvo et al. (2004), Gonze et al. (2005) and Li et al. (2006b), the synchronization was investigated for coupled nonidentical genetic oscillators. In Li et al. (2007), based on a system biology approach, the authors provided a general theoretical result on the synchronization of genetic oscillators with stochastic perturbations.
It is now well known that the slow processes of transcription, translation, and translocation or the finite switching speed of amplifiers will inevitably cause time delays, which should be taken into account in the biological systems or artificial genetic networks in order to have more accurate models (Li et al. 2014, 2008). The effects of transcriptional delays should be assessed in the dynamics of genetic networks whose time scales are short and transcription is regulated by feedback (Wang et al. 2008). The time-delay can be of a discrete nature, which assumes each macromolecule takes the same length of time to translocate from its place of synthesis to the location where it exerts an effect. The time-delay can also be time-varying where the delay changes as time changes. In the context of GRNs, both discrete time-delays and time-varying delays have recently been considered in Cao and Ren (2008), Monk (2003), Grammaticos et al. (2006) and Wang et al. (2008).
It should be pointed out that, in most existing literature considering delays in GRNs, only the stability has been considered, and the important synchronization behavior has not received much attention yet. Furthermore, almost all relevant research works have assumed that the time delays involved in GRNs are bounded. This is, unfortunately, not always the case in practice. If movement of mRNA from a transcription site to translation sites is an active process with a significant range of transport times for individual molecules, unbounded delay would be the proper modeling framework. For example, it has been shown in Smolen et al. (2000) that the time-delay can occur in a distributed hence unbounded way. Therefore, it is of great interest in both theory and applications to investigate the synchronization problem of the genetic regulatory networks with unbounded delays. To the best of the authors’ knowledge, up to now, little effort has been made towards such a challenging problem, which motivates the present study.
In this paper, we investigate a new synchronization problem for the collective dynamics among genetic oscillators with unbounded time-varying delay. The dynamical system under consideration consists of an array of linearly coupled identical genetic oscillators with each oscillators having unbounded time-delays. It is worth noting that, in Chen and Wang (2007), pioneering research has been carried out for the power-rate stability of dynamical systems with unbounded time-varying delays and neat results have been reported. Motivated by the excellent work of Chen and Wang (2007), we put forward a new concept called power-rate synchronization in order to cater the unbounded time-delays in GRNs. Notice that the power-rate synchronization is significantly different from the traditional asymptotical synchronization and the exponential synchronization. By resorting to the Lyapunov functional method and properties of Kronecker product, we develop a new matrix inequality approach to derive several sufficient conditions under which the coupled genetic oscillators are synchronized in the power-rate sense. Illustrative example is presented to show the effectiveness of the obtained results.
The rest of this paper is organized as follows. In “Problem formulation and preliminaries” section, problem formulation and preliminaries are given. In “Power-rate synchronization” section, sufficient criteria are derived for the power-rate synchronization of coupled genetic oscillators with unbounded time-varying delay. In “Illustrative example” section, an example is given to show the effectiveness of the proposed results. Finally, conclusions are drawn in the last section.
Problem formulation and preliminaries
Consider the genetic oscillator with unbounded time-varying delay described by the following equation Li et al. (2006b):
where \(x(t)=[x_{1}(t),x_{2}(t),\ldots ,x_{n}(t)]^{T}\) represents the concentrations of proteins, RNAs and chemical complexes; \(A\) and \(B_i\) are matrices in \({\mathbb {R}}^{n\times n}\) while \(Ax(t)\) includes the degradation terms and all the other linear terms in the genetic oscillator; \(f(x(t-\tau (t)))=[f_{1}(x_{1}(t-\tau (t))), \ldots ,\,f_{n}(x_{n}(t-\tau (t)))]^{T}\) and \(\widetilde{g}(x(t-\tau (t)))=[\widetilde{g}_{1}(x_{1}(t-\tau (t))),\ldots ,\widetilde{g}_{n}(x_{n}(t-\tau (t)))]^{T}\) with \(f_i(x_i)\) and \(\widetilde{g}_i(x_i)\) being monotonic increasing or decreasing regulatory functions that are usually of the Michaelis-Menten or Hill form; the unbounded time-varying delay function satisfies \(\tau (t)\le \eta t\) with \(0<\eta <1\). In this paper, we also assume that \(f_i(x)\) is a monotonic increasing function of the Hill form
and \(\widetilde{g}_i(x)\) is a monotonic decreasing function of the following form
where \(H_i\) and \(H_i^*\) are the Hill coefficients. We further assume that the \(i\)th column of \(B_{1}\) and \(B_{2}\) are zeros if \(f_i, \widetilde{g}_i\equiv 0\).
Since
system (1) can be rewritten as follows:
where \(e_n=[1,1,\ldots ,1]^T\in \mathbb {R}^{n}\). Noticing that \(f_i\) and \(g_i\) are monotonically increasing functions with saturation, we have
for all \(x\), \(y\in {\mathbb {R}}\) with \(x\ne y\), where \(F_i\) and \(G_i\) are real constants.
Remark 1
As indicated in Li et al. (2006a), the genetic oscillator (2) can be regarded as a kind of Lur’e system that can then be investigated by using the fruitful Lur’e system method in control theory.
In this paper, we consider the dynamical system consisting of \(N\) linearly coupled identical genetic oscillators with each oscillator being an \(n\)-dimensional dynamical system:
where \(x_i(t)\in {\mathbb {R}}^n\) is the state vector of the \(i\)th genetic oscillator, \(D=(d_{ij})\in {\mathbb {R}}^{n\times n}\) is inner coupling matrix. \(C=(c_{ij})_{N\times N}\) is the coupling configuration matrix representing the coupling strength and the topological structures of the network, in which \(c_{ij}=c_{ji}\) is defined as follows:
Remark 2
Similar to Li et al. (2006a), the synchronization problem considered in this paper is actually for coupled genetic oscillators with SUM regulatory logic, that is, each transcription factor acts additively to regulate a gene or, in other words, the regulatory function sums over all the inputs. As explained in Li et al. (2006a), such a SUM logic does exist in many natural genetic networks where an additive input function is to provide a gene with multiple promoters, each responding to one of the inputs.
In the following, we give the definition for power-rate synchronization.
Definition 1
Suppose that there exist constants \(K\), \(\epsilon >0\) and \(T>0\) such that \(\Vert x_i(t)-x_j(t)\Vert \le K t^{-\epsilon }\) for all \(t>T\) and \(i,j=1,2,\ldots ,N\). Then, the system (3) is said to be power-rate synchronized.
To obtain our main results, some definitions and lemmas in Wu and Chua (1995) and Wang and Cao (2006) are introduced here, which will be used throughout this paper.
Definition 2
Let \(\hat{{\mathbb {R}}}\) denote a ring and \({\mathbf{M}} _{n\times m}(\hat{{\mathbb {R}}})\) be the set of \(n\times m\) matrix with entries in \(\hat{{\mathbb {R}}}\). \(T(\hat{{\mathbb {R}}},B)\) is defined as the set of matrices with entries in \(\hat{{\mathbb {R}}}\) such that the sum of the entries in each row is equal to \(B\) for some \(B\in \hat{{\mathbb {R}}}\).
Definition 3
\({\mathbf{M}} _{1}^{N}(1)\) is composed of matrices with \(N\) columns, and each row of \(\tilde{M}\in {\mathbf{M}} _{1}^{N}(1)\) contains zeros and exactly one entry \(\alpha _{i}\) and one entry \(-\alpha _{i}\), \(\alpha _{i}\ne 0\).
Definition 4
\({\mathbf{M}} _{1}^{N}(n)\) is defined as \(\mathbf{M }_{1}^{N}(n)=\{\mathbf{M }={\tilde{M}}\otimes {I_{n}}| {\tilde{M}}\in {\mathbf{M }_{1}^{N}}(1)\}\), i.e., \(\mathbf{M }\in {\mathbf{M }_{1}^{N}}(n)\) is obtained by replacing entry \(m_{ij}\) in \(\tilde{M}\in {\mathbf{M}} _{1}^{N}(1)\) with \(m_{ij}I_{n}\), where \(I_n\) is the \(n\)-dimension identity matrix; the notation \(\otimes \) indicates the Kronecker product of two matrices; \({\mathbf{M}} _{2}^{N}(n)\) are matrices \({\mathbf{M}} \) in \({\mathbf{M}} _{1}^{N}(n)\) such that for any pair of indexes \(i\) and \(j\), there exist indexes \(i_{1},i_{2},\ldots ,i_{l}\) with \(i_{1}=i\) and \(i_{l}=j\), and \(p_{1},p_{2},\ldots ,p_{l-1}\) such that \({\mathbf{M}} _{({p_{q}},i_{q})}\ne 0\) and \({\mathbf{M}} _{({p_{q}},i_{q+1})}\ne 0\) for all \(1\le q<l\).
A nonnegative real-valued function is defined as follows to measures the distance between the various nodes:
From the property of \({\mathbf{M}} \in {\mathbf{M}} _{2}^{N}(n)\), \(d(x)\rightarrow 0\) if and only if \(||x_{i}-x_{j}||\rightarrow 0\) for all \(i\) and \(j\), \(1\le i,\,j\le N\), which implies that the dynamical system (3) achieves synchronization when \(d(x)\rightarrow 0\). Especially, if we take
then \({\mathbf{M}} _{1}\in {\mathbf{M}} _{2}^{N}(n)\) is a \((N-1)n\times Nn\) real-valued matrix, and \(d(x)=\sum \limits _{i=1}^{N-1}||x_{i}-x_{i+1}||^{2}\).
Lemma 1
Let \(W\) be a \(N\times N\) matrix in \(T(\hat{{\mathbb {R}}},K)\), then the \((N-1)\times (N-1)\) matrix \(H\) defined by \(H=MWV\) satisfies \(MW=HM\) where \(M\) is the \((N-1)\times N\) matrix and \(V\) is the \(N\times (N-1)\) matrix
and \({\mathbf{1}}\) is the multiplicative identity of \(\hat{{\mathbb {R}}}\). The matrix \(H\) can be written explicitly as \(H_{(i,j)}=\sum_{k=1}^j[W_{(i,k)}-W_{(i+1,k)}]\) for \(i,j\in \{1,2,\ldots ,N-1\}\).
Lemma 2
A symmetric irreducible matrix \(B\) satisfies the condition (4) if and only if there exists a \(p\times N\) matrix \(M\in {\mathbf{M}} _{2}^N(1)\) such that \(B=-M^{T}M.\)
Lemma 3
(Wang et al. 2006) Let \(\Sigma \), \(R\), \(S\) be real matrices of appropriate dimensions and \(\Sigma \) is positive definite. Then, for any vectors \(x\) and \(y\) of appropriate dimensions, the following inequality holds:
Lemma 4
[Schur complement (Boyd et al. 1994)]. The following linear matrix inequality (LMI)
where \(Q(x)=Q^{T}(x)\), \(R(x)=R^{T}(x)\), and \(S(x)\) depends affinely on \(x\), is equivalent to the following condition:
Power-rate synchronization
Theorem 1
The network (3) is power-rate synchronized if there exist positive definite matrix \(P=(p_{ij})_{n\times n}\in {\mathbb {R}}^{n\times n}\), positive definite diagonal matrices \(Q=\text{diag}\{q_{1},q_{2},\ldots , q_{n}\}\in {\mathbb {R}}^{n\times n}\), \(\Sigma =\text{diag}\{\sigma _{1}, \sigma _{2}, \ldots , \sigma _{n}\}\in {\mathbb {R}}^{n\times n}\), a symmetric matrix \(\Delta =(\Delta _{ij})_{n\times n}\in {\mathbb {R}}^{n\times n}\), such that
and
where \(F=\text{diag}\{F_1,F_2,\ldots ,F_n\}\) and \(G=\text{diag}\{G_1,G_2,\ldots ,G_n\}\).
Proof
Let \(e_N=[1,1,\ldots ,1]^T\in \mathbb {R}^N\), \(J=e_Ne_N^T\), \(U=J-NI_N\); Then \(u_{ij}=1(i\ne j)\), \(u_{ii}=-(N-1),\) \(i,j=1,2,\ldots ,N\). Obviously, \(U\) is an irreducible symmetric matrix and satisfies condition (4). It follows from Lemma 2 that there exists a \(p\times N\) matrix \(\tilde{M}\in {\mathbf{M}} _{2}^{N}(1)\) such that \(U=-\tilde{M}^{T}\tilde{M}\). Let \({\mathbf{M}} =\tilde{M}\otimes I_{n}\), then \({\mathbf{M}} \in {\mathbf{M}} _{2}^{N}(n)\) and denote \({\mathbf{f}} (x(t-\tau (t)))=[f^{T}(x_{1}(t-\tau (t))), f^{T}(x_{2}(t-\tau (t))), \ldots , f^{T}(x_{N}(t-\tau (t)))]^{T}\), \( {\mathbf{g}} (x(t-\tau (t)))=[g^{T}(x_{1}(t-\tau (t))), g^{T}(x_{2}(t-\tau (t))), \ldots , g^{T}(x_{N}(t-\tau (t)))]^{T}\), \( x_{i}(t)=[x_{i,1}(t),x_{i,2}(t), \ldots , x_{i,n}(t)]^{T}\), \( x(t)=[x_{1}^{T}(t), x_{2}^{T}(t), \ldots , x_{N}^{T}(t)]^{T}\), \( {\mathbf{A}} =I_{N}\otimes A\), \(\bar{\mathbf{A}}=I_{p}\otimes A\), \({\mathbf{B}} _1=I_{N}\otimes B_1\), \(\bar{\mathbf{B}}_1=I_{p}\otimes B_1\), \({\mathbf{B}} _2=I_{N}\otimes B_2\), \(\bar{\mathbf{B}}_2=I_{p}\otimes B_2\), \(\varvec{\Delta }=I_{N}\otimes \Delta \), \(\bar{\varvec{\Delta}}=I_{p}\otimes \Delta \), \( {\mathbf{P}} =I_{p}\otimes P\), \({\mathbf{Q}} =I_{p}\otimes Q\), \({\mathbf{C}} =C\otimes D\), \({\mathbf{u}} =[(B_2\cdot e_n)^T, (B_2\cdot e_n)^T, \ldots , (B_2\cdot e_n)^T]^{T}\). We can rewrite the network (3) as follows:
Let \(y(t)={\mathbf{M}} x(t)=[y_{1}^{T}(t), y_{2}^{T}(t), \ldots , y_{p}^{T}(t)]^{T}\), \(y_{i}(t)=[y_{i,1}(t), y_{i,2}(t), \ldots , y_{i,n}(t)]^{T}\), where \(y_{i}(t)\) is assumed to be \(\alpha _{i}(x_{i_{1}}(t)-x_{i_{2}}(t))\) with \(\alpha _{i}\ne 0\), \(i=1,2,\ldots , p\). We further let \(\bar{x}_{j}(t)=[x_{1,j}(t), x_{2,j}(t),\ldots , x_{N,j}(t)]^{T}\), then \(\bar{y}_{j}(t)=\tilde{M}\bar{x}_{j}(t)\), \(j=1, 2, \ldots , n\).
By Lemma 4, condition (6) is equivalent to
then we can find two sufficient small constants \(\beta >0\) and \(\epsilon >0\) such that
In addition, a sufficiently large constant \(T>0\) can be found such that
We always assume that \(t>T\) in the following proof. Consider the following Lyapunov function
Defining a function \(S(t)\) as \(S(t)=\sup _{s\le t}V(x(s))\), we can see that \(S(t)\) is non-decreasing, \(V(x(t))\le S(t)\) and \(S(t)\) is bounded. Furthermore, for all \(t\ge T\), one can obtain \(S(t)=S(T)\). Clearly, for any \(t_0>T\), if \(V(x(t_0))<S(t_0)\), then \(S(t)\) is non-increasing at \(t_0\). Now, suppose that \(V(x(t_0))=S(t_0)\), we will need to prove that \(S(t)\) is also non-increasing at \(t_0\).
Calculating the time derivative of \(V(x(t))\) along the trajectories of (8), one obtains
It follows from the properties of \({\mathbf{M}} \) that
which leads to
Noting that \(\frac{\epsilon }{t_0} <\beta \), we obtain
An application of Lemma 3 yields
and
According to the assumptions that \(P\ge FQF\) and \(P\ge G\Sigma G\), one can obtain
and
It follows from (12), (13), (14) and (15) that
Furthermore, one has
and
Hence, we gets
which implies that \(S(t)\) is also non-increasing at \(t_0\). It follows from above analysis that \(S(t)=S(T)\) for all \(t\ge T\), which implies that \(\Vert y(t)\Vert =O(t^{-\frac{\epsilon }{2} })\). This completes the proof. \(\square \)
Remark 3
If the time delay is bounded and differentiable and \(\dot{\tau }(t)\le \tau < 1\), following the similar method, we can obtain a sufficient condition for the delayed coupled genetic oscillators to be globally exponentially synchronized:
where the Lyapunov functional can be constructed as
The proof is similar and omitted here.
If the coupling matrix \(D\) is a diagonal matrix, then the following result can be obtained.
Corollary 1
The network (3) is power-rate synchronized if there exist diagonal matrices \(P=\text{diag}\{p_1,p_2,\ldots ,p_n\}>0\), \(Q=\text{diag}\{q_{1},q_{2},\ldots , q_{n}\}>0\), \(\Sigma =\text{diag}\{\sigma _{1}, \sigma _{2}, \ldots , \sigma _{n}\}>0\), \(\Delta =\text{diag}\{\delta _{1}, \delta _{2}, \ldots , \delta _{n}\}\) and an irreducible symmetric matrix \(U=(u_{ij})\in {\mathbb {R}}^{N\times N}\) satisfying condition (4), such that
and
where \(F=\text{diag}\{F_1,F_2,\ldots ,F_n\}\) and \(G=\text{diag}\{G_1,G_2,\ldots ,G_n\}\).
Proof
Since
and from (16), one has
This completes the proof. \(\square \)
Theorem 2
The network (3) is power-rate synchronized if there exist positive definite matrix \(P=(p_{ij})_{n\times n}\in {\mathbb {R}}^{n\times n}\), positive definite diagonal matrices \(Q=\text{diag}\{q_{1},q_{2},\ldots , q_{n}\}\in {\mathbb {R}}^{n\times n}\), \(\Sigma =\text{diag}\{\sigma _{1}, \sigma _{2}, \ldots , \sigma _{n}\}\in {\mathbb {R}}^{n\times n}\), a symmetric matrix \(\Delta =(\Delta _{ij})_{n\times n}\in {\mathbb {R}}^{n\times n}\), such that
and
where \({\mathbf{F}} =I_{N-1}\otimes F\), \({\mathbf{G}} =I_{N-1}\otimes G\), \(H=\tilde{M}CV\), \({\mathbf{H}} =H\otimes D\) and \(V\) is defined in Lemma 1 and \(\tilde{M}\) is defined in the proof.
Proof
Suppose that
and \(\tilde{M}\) is a \((N-1)\times N \) real-valued matrix. Let \({\mathbf{M}} _{1}=\tilde{M}\otimes I_{n}\), \(y(t)={\mathbf{M}} _{1}x(t)=[y_{1}^{T}(t), y_{2}^{T}(t), \ldots , y_{N-1}^{T}(t)]^{T}\), \(y_{i}(t)=[y_{i,1}(t), y_{i,2}(t), \ldots , y_{i,n}(t)]^{T}\). According to the structure of \({\mathbf{M}} _{1}\), it is easy to show that \(y_{i}(t)=x_{i}(t)-x_{i+1}(t), i=1, 2, \ldots , N-1\). We denote
By Lemma 4, condition (22) is equivalent to
then we can find two sufficient small constants \(\beta >0\) and \(\epsilon >0\) such that
In addition, a sufficiently large constant \(T>0\) can be found such that
Consider the following Lyapunov function
Following the same method in Theorem 1, one obtains
Let \(\phi \left( y(t-\tau (t))\right) ={\mathbf{M}} _{1}{\mathbf{f}} \left( x(t-\tau (t))\right) \) and \(\varphi \left( y(t-\tau (t))\right) ={\mathbf{M}} _{1}{\mathbf{g}} \left( x(t-\tau (t))\right) ,\) it follows from Lemma 3 that
and
Furthermore, since \(\tilde{\mathbf{P}}\ge {\mathbf{F}} \tilde{\mathbf{Q}} {\mathbf{F}} \) and \(\tilde{\mathbf{P}}\ge {\mathbf{G}} \tilde{\varvec{\Sigma}} {\mathbf{G}} \), thus
Denote \(\varvec{\Omega }_1=\beta \tilde{\mathbf{P}}+\tilde{\mathbf{P}}\tilde{\mathbf{A}} +\tilde{\mathbf{A}}^T\tilde{\mathbf{P}} +\tilde{\mathbf{P}}\tilde{\mathbf{B}}_{1}\tilde{\mathbf{Q}}^{-1}\tilde{\mathbf{B}}_{1}^T\tilde{\mathbf{P}} +\tilde{\mathbf{P}}\tilde{\mathbf{B}}_{2}\tilde{\varvec{\Sigma}}^{-1}\tilde{\mathbf{B}}_{2}^T\tilde{\mathbf{P}} +2(1-\eta )^{-\epsilon }\tilde{\mathbf{P}}\), one has
which implies that \(S(t)\) is also non-increasing at \(t_0\). It follows from above analysis that \(S(t)=S(T)\) for all \(t\ge T\), which implies that \(\Vert y(t)\Vert =O(t^{-\frac{\epsilon }{2} })\). This completes the proof. \(\square \)
According to the proof of Theorem 2, one has the following corollary.
Corollary 2
The network (3) is power-rate synchronized if there exist positive definite matrix \(P=(p_{ij})_{n\times n}\in {\mathbb {R}}^{n\times n}\), positive definite diagonal matrices \(Q=\text{diag}\{q_{1},q_{2},\ldots , q_{n}\}\in {\mathbb {R}}^{n\times n}\), \(\Sigma =\text{diag}\{\sigma _{1}, \sigma _{2}, \ldots , \sigma _{n}\}\in {\mathbb {R}}^{n\times n}\), a symmetric matrix \(\Delta =(\Delta _{ij})_{n\times n}\in {\mathbb {R}}^{n\times n}\), such that
and
where \({\mathbf{F}} =I_{N-1}\otimes F\), \({\mathbf{G}} =I_{N-1}\otimes G\), \(H=\tilde{M}CV\), \({\mathbf{H}} =H\otimes D\) and \(V\) is defined in Lemma 1 and \(\tilde{M}\) is defined in Theorem 2, and \(\tilde{\varvec{\Delta}}=I_{N-1}\otimes \Delta \).
Remark 4
Likewise, if the time delay is bounded and differentiable and \(\dot{\tau }(t)\le \tau <1\), following the similar method, we can obtain a sufficient condition which is a minor revision of Theorem 2 for the delayed coupled genetic oscillators to be globally exponentially synchronized:
where the Lyapunov functional is constructed as
The proof is omitted.
Remark 5
A new synchronization problem for the collective dynamics among genetic oscillators with unbounded time-varying delay is investigated. A new concept called power-rate synchronization, which is different from both the asymptotical synchronization and the exponential synchronization, is put forward to facilitate handling the unbounded time-varying delays. An LMI-based sufficient condition is derived for the existence of the desired synchronization, which ensures the power-rate stability in the presence of time-delays. The synchronization of the addressed genetic oscillators can be readily checked by the solvability of a set of LMIs, which can be done by resorting to the Matlab LMI toolbox. It should be mentioned that, in the past decade, LMIs have gained much attention for their computational tractability and usefulness in many areas because the so-called interior point method has been proven to be numerically very efficient for solving the LMIs. In next section, an illustrative example will be provided to show the application potential of the proposed techniques in a population of \(N\) coupled SCN neuron model oscillators.
Illustrative example
Example. In the following, we consider a population of \(N\) coupled SCN neuron model oscillators. The single cell or genetic oscillator is described by the classical Goodwin model (Goodwin 1965). In this model, a clock gene mRNA (\(X\)) produces a clock protein (\(Y\)), which activates a transcriptional inhibitor (\(Z\)). \(Z\) inhibits the transcription of the clock gene, completing the cycle. The oscillators coupled through the release and receiving of neurotransmitter among neurons. The release of the neurotransmitter is supposed to be fast with respect to the 24 h timescale of the oscillators. In this paper, we assume that the light \(L=0\). \(V\) describes the evolution of the neurotransmitter in the neuron. The equation for each oscillator is given as follows:
where \(v_1\), \(v_2\), \(v_3\), \(v_4\), \(v_5\), \(v_6\), \(v_7\), \(v_8\) are positive constants. The concentrations are express in nM, and the parameters are set as \(m=12\), \(v_1=1\,\text{nM}\,\text{h}^{-1}\); \(v_2=v_5=v_6=1.2\,\text{h}^{-1}\); \(v_3=2\,\text{h}^{-1}\); \(v_4=1.5\,\text{h}^{-1}\); \(v_7=0.2\,\text{h}^{-1}\); \(v_8=2\,\text{h}^{-1}\); \(\tau (t)=0.1t\), \(N=10\); the coupling matrix \(C\) are given as: \(c_{ii}=-2+\frac{2}{10}\); \(c_{ij}=\frac{2}{10},\,i\ne j\); and the inner linking matrix \(D=(d_{ij})\) with \(d_{14}=3\) and other elements are 0.
By applying Theorem 1 and using Matlab LMI Toolbox, we can find the feasible solutions for (6) and (7), which indicate that the coupled network can achieve power-rate synchronization. In Fig. 1a, we plot the time evolution of the mRNA concentrations (X) of all the uncoupled oscillators with random initial values. In Fig. 1b, we show the error of the uncoupled oscillators. From Fig. 1a, b, we can see that there is no synchronization between the oscillators without coupling. Figure 2a shows the time evolution of the mRNA concentration (X) of all the coupled oscillators with random initial values. Also, Fig. 2a shows that the synchronization is realized between the oscillators with linear coupling. So, linear coupling is an effective way to achieve synchronization. Figure 2b shows the time evolution of the synchronization error, which further confirms that the coupled network can achieve power-rate synchronization.
where \(X_i\), \(Y_i\), \(Z_i\) describe the dynamics of the oscillator in \(i\)th neuron, and \(V_i\) describes the evolution of the neurotransmitter in the \(i\)th neuron.
In our future research, it would be very interesting to see how promising it would be to apply our developed results to other well-known genetic oscillators, e.g. the ones described in Elowitz and Leibler (2000). Genetic regulatory network is a dynamical system that consists of a finite number of different subsystems rather than a single, isolated system. For example, there are many genomes in a cell which leads to the existence of different regulatory network. These regulatory networks are activated in the internal and external conditions which is variable. That is to say, in certain biological environment, gene regulatory network is a hybrid system. Therefore, in the near future, we will discuss the dynamics of switching GRNs.
Conclusions
In this paper, we have investigated the synchronization problem on the genetic oscillators with unbounded time-varying delays. Some criteria are given to ensure the power-rate synchronization of the coupled genetic oscillators. The obtained conditions are derived in terms of matrix inequalities. Synchronization with some power convergence rate is first proposed on genetic oscillators. From Chen and Wang (2007) and the concept of synchronization, we know that there indeed exist some dynamical systems which are power-rate synchronized but not exponentially synchronized. We have employed a simulation example to illustrate the effectiveness of the proposed results.
References
Boyd S, Ghaoui LE, Feron E, Balakrishnan V (1994) Linear matrix inequalities in system and control theory. SIAM, Philadelphia
Cao J, Ren F (2008) Exponential stability of discrete-time genetic regulatory networks with delays. IEEE Trans Neural Netw 19(3):520–523
Chen TP, Wang LL (2007) Power-rate global stability of dynamical systems with unbounded time-varying delays. IEEE Trans Circuits Syst II 54(8):705–709
Elowitz MB, Leibler S (2000) A synthetic oscillatory network of transcriptional regulators. Nature 403:335–338
Fraser K, O’Neill P, Wang Z, Liu X (2004) Copasetic analysis: a framework for the blind analysis of microarray imagery. Syst Biol 1:190–196
Garcia-Ojalvo J, Elowitz MB, Strogatz SH (2004) Modelling a synthetic multicellular clock: repressilators coupled by quorum sensing. Proc Natl Acad Sci USA 101:10955–10960
Gonze D, Bernard S, Waltermann C, Kramer A, Herzel H (2005) Spontaneuous synchronization of coupled circadian oscillators. Biophys J 89:120–129
Goodwin BC (1965) Oscillatory behavior in enzymatic control processes. In: Weber G (ed) Advances in enzyme regulation. Pergamon Press, Oxford, pp 425–438
Grammaticos B, Carstea AS, Ramani A (2006) On the dynamics of a gene regulatory network. J. Phys. A Math. Gen. 39:2965–2971
Huang T, Li C, Liu X (2008) Synchronization of chaotic systems with delay using intermittent linear state feedback. Chaos 18: Article No. 033122
Kuznetsov A, Kaern M, Kopell N (2004) Synchronization in a population of hysteresis-based genetic oscillators. SIAM J Appl Math 65:392–425
Lewin B (1999) Genes VII. Oxford University Press, Oxford
Li C, Chen G (2004) Synchronization in general complex dynamical networks with coupling delays. Phys A 343:263–278
Li C, Chen L, Aihara K (2006a) Stability of genetic networks with SUM regulatory logic: Lur’e system and LMI approach. IEEE Trans Circuits Syst I 53:2451–2458
Li C, Chen L, Aihara K (2006b) Synchronization of coupled nonidentical genetic oscillators. Phys Biol 3:37–44
Li C, Chen L, Aihara K (2007) Stochastic synchronization of genetic oscillator networks. BMC Syst Biol. doi:10.1186/1752-0509-1-6
Li C, Feng G, Huang T (2008) On hybrid impulsive and switching neural networks. IEEE Trans Syst Man Cybern Part B 38(6):1549–1560
Li C, Yu W, Huang T (2014) Impulsive synchronization schemes of stochastic complex networks with switching topology: average time approach. Neural Netw 54:85–94
Li N, Cao J, Hayat T (2014) Delay-decomposing approach to robust stability for switched interval networks with state-dependent switching. Cogn Neurodyn 8:313–326
Lu WL, Chen TP (2004) Synchronization of coupled connected neural networks with delays. IEEE Trans Circuits Syst I 51:2491–2503
McMillen D, Kopell N, Hasty J, Collins JJ (2002) Synchronizing genetic relaxation oscillators by intercell signalling. Proc Natl Acad Sci USA 99:679–684
Monk NAM (2003) Oscillatory expression of Hes1, p53, and NF-\(\kappa \)B driven by transcriptional time delays. Curr Biol 13:1409–1413
Qiu J, Cao J (2009) Global synchronization of delay-coupled genetic oscillators. Neurocomputing 72(16–18):3845–3850
Ren F, Cao J (2008) Asymptotic and robust stability of genetic regulatory networks with time-varying delays. Neurocomputing 71:834–842
Ren F, Cao F, Cao J (2015) Mittag–Leffler stability and generalized Mittag–Leffler stability of fractional-order gene regulatory networks. Neurocomputing 160:185–190
Smolen P, Baxter DA, Byrne JH (2000) Modeling transcriptional control in gene networks: methods, recent results, and future directions. Bull Math Biol 62:247–292
Wang R, Chen L (2005) Synchronizing genetic oscillators by signaling molecules. J Biol Rhythms 20:257–269
Wang W, Cao J (2006) Synchronization in an array of linearly coupled networks with time-varying delay. Phys A 366:197–211
Wang Z, Liu Y, Li M, Liu X (2006) Stability analysis for stochastic Cohen–Grossberg neural networks with mixed time delays. IEEE Trans Neural Netw 17:814–820
Wang Z, Gao H, Cao J, Liu X (2008) On delayed genetic regulatory networks with polytopic uncertainties: robust stability analysis. IEEE Trans NanoBiosci 7(2):154–163
Wang Z, Yang F, Ho DWC, Swift S, Tucker A, Liu X (2008) Stochastic dynamic modeling of short gene expression time series data. IEEE Trans NanoBiosci 7(1):44–55
Wang Y, Cao J, Li L (2010) Global robust power-rate stability of delayed genetic regulatory networks with noise perturbation. Cogn Neurodyn 4(1):81–90
Wu CW, Chua LO (1995) Synchronization in an array of linearly coupled dynamical system. IEEE Trans Circuit Syst I 42(8):430–447
Xiao M, Zheng WX, Cao J (2014) Stability and bifurcation of genetic regulatory networks with small RNAs and multiple delays. Int J Comput Math 91(5):907–927
Acknowledgments
This project was funded by the Deanship of Scientific Research (DSR), King Abdulaziz University, under Grant No. (17-130-36-HiCi). The authors, therefore, acknowledge with thanks DSR technical and financial support.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Alofi, A., Ren, F., Al-Mazrooei, A. et al. Power-rate synchronization of coupled genetic oscillators with unbounded time-varying delay. Cogn Neurodyn 9, 549–559 (2015). https://doi.org/10.1007/s11571-015-9344-2
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11571-015-9344-2