Summary
Some new hydrazinium salts of 2-pyrazinecarboxylate, 2,3-pyrazinedicarboxylate, 3,5-pyrazoledicarboxylate and 4,5-imidazoledicarboxylate have been prepared. The in vitro antibacterial screening of the free acids and their hydrazinium salts has been carried out against Escherichia coli, Salmonella typhiiand Vibrio cholerae. The antibacterial activities of the prepared hydrazinium salts show more promising activity than the corresponding free acids and the standard positive control antibiotic, Co-trimoxazole.
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References
R. Cruickshank (1968) Medical Microbiology: A Guide to Diagnosis and Control of Infection EditionNumber11 E & S Livingstone Ltd Edinburgh, London
K. Kuppusamy B.N. Sivasankar S. Govindarajan (1995) ArticleTitlePreparation, characterization and thermal properties of some new hydrazinium carboxylates Thermochimica Acta 259 251–262 Occurrence Handle10.1016/0040-6031(95)02257-3
T. Premkumar (2002) Synthesis and structural, spectroscopic, and thermal characterization of pyrazine, pyrazole and imidazole carboxylates of metal with hydrazine, PhD thesis Bharathiar University Coimbatore, India
T. Premkumar S. Govindarajan (2003) ArticleTitlePreparation, spectral and thermal studies of pyrazinecarboxylic acids and their hydrazinium salts Proceedings of the Indian Academy of Sciences (ChemicalSciences) 115 103–111
E.W. Schmidt (1984) Hydrazine and its Derivatives: Preparation, Properties and Applications Wiley Interscience New York
S. Yasodhai S. Govindarajan (1999) ArticleTitlePreparation and thermal behaviour of some hydrazinium dicarboxylates Thermochimica Acta 338 113–123 Occurrence Handle10.1016/S0040-6031(99)00202-6
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Premkumar, T., Govindarajan, S. Antimicrobial study of pyrazine, pyrazole and imidazole carboxylic acids and their hydrazinium salts. World J Microbiol Biotechnol 21, 479–480 (2005). https://doi.org/10.1007/s11274-004-2041-7
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DOI: https://doi.org/10.1007/s11274-004-2041-7