Abstract
Cyclization of 1,2-diamino-4(4-chlorophenyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile 2 with a variety of electrophilic reagents results in formation of a new series of pyrimidine heterocycles including pyrimidotriazepines, pyrimidotriazines and triazolopyrimidines. Some newly synthesized compounds are tested for their antibacterial activity against Gram-positive and Gram-negative bacteria.
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Shehta, W., Abdel Hamid, A.M. Synthesis and Antibacterial Acivity of Some Novel Pyrimidine-Based Heterocycles. Russ J Gen Chem 89, 806–812 (2019). https://doi.org/10.1134/S1070363219040273
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DOI: https://doi.org/10.1134/S1070363219040273