Abstract
The kinetics and mechanism of the condensation of amino acids with pyridoxal were studied in relation to the amino acid structure, solvent, pH, and temperature. A spectrophotometric study revealed several kinetically discernible reaction steps. The condensation rate as a function of pH passes through a maximum, which is caused by formation of two intermediates of different structures. The final products of the condensation and subsequent hydrolysis are pyridoxamine and α-keto acids. The reaction mechanism was suggested.
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Translated from Zhurnal Obshchei Khimii, Vol. 75, No. 9, 2005, pp. 1538–1541.
Original Russian Text Copyright © 2005 by Pishchugin, Tuleberdiev.
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Pishchugin, F.V., Tuleberdiev, I.T. Kinetics and Mechanism of the Condensation of Pyridoxal with Amino Acids. Russ J Gen Chem 75, 1465–1468 (2005). https://doi.org/10.1007/s11176-005-0447-z
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DOI: https://doi.org/10.1007/s11176-005-0447-z