Abstract
Water-soluble polymer compositions of the lipophilic complex of cis-bis[(nitroxyethyl)-isonicotinamide-N]-tetrachloroplatinum(iv) with antitumor activity were prepared. The complex was solubilized by amphiphilic copolymers of N-vinylpyrrolidone (VP) with (di)methacrylates synthesized by radical copolymerization in toluene in the absence of any inhibitors of polymer chain growth. Aqueous buffer solutions of the nanostructures were studied by dynamic light scattering, and the influence of the concentrations of the complex and copolymer and temperature on the nanoparticle size (hydrodynamic radius) was estimated. The nanostructures based on the VP copolymer with triethylene glycol dimethacrylate are shown to be thermosensitive and decompose when the temperature rises to physiologically significant values. According to the TEM data, the polymer particles are spherical and contain inclusions of the PtIV complex ∼4 nm in size. The polymer compositions were studied using CV, TGA, and DSC methods. The results of IR spectroscopic analysis of the polymer compositions and quantum chemical modeling indicate the formation of the hydrogen bond between the NH groups of the complex and VP copolymer.
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Based on the materials of the VIII All-Russian Kargin Conference “Polymers-2020” (November 9–13, 2020, Moscow, Russia).
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 9, pp. 1832–1844, September, 2021.
The authors are grateful to E. O. Perepelitsyna for chromatographic analysis of the copolymers and to R. A. Manzhos for help in CV experiment and useful discussion.
This work carried out in the framework of state assignment (Themes Nos. AAAA-A19-119041090087-4, AAAAA19-119032690060-9, AAAA-A19-119071890015-6, and AAAA-A19-119061890019-5) using equipment of the Analytical Center for Collective Use at the Institute of Problems of Chemical Physics (Russian Academy of Sciences).
This paper does not contain descriptions of studies on animals or humans.
The authors declare no competing interests.
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Kurmaz, S.V., Fadeeva, N.V., Fedorov, B.S. et al. Amphiphilic copolymers of N-vinylpyrrolidone with (di)methacrylates as promising carriers for the platinum(IV) complex with antitumor activity. Russ Chem Bull 70, 1832–1844 (2021). https://doi.org/10.1007/s11172-021-3289-x
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DOI: https://doi.org/10.1007/s11172-021-3289-x